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How do you stimulate prolactin receptors? 

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Only a few GnRH neurons express prolactin receptors (Prlrs), however, and thus prolactin must act indirectly in the underlying neural circuitry.
It seems that prolactin does not induce its own receptors in the rat liver by stimulation of prostaglandins in this tissue.
It is concluded that prolactin activates medullary adenylate cyclase, and may do so by occupying ADH receptors.
These findings suggest that the drug acts on the central nervous system to stimulate prolactin release.
As little as 0.5 mg prolactin significantly increases receptors, while doses above the 2 mg optimum are apparently less effective.
In this report we demonstrate that prolactin regulates the level of cryptic receptors.
This apparent down-regulation of prolactin receptors may result from an endocytosis or compartmentalization of the hormone-receptor complex and may be involved in the mechanism of action of prolactin.
It is now clear that cellular responsiveness to prolactin can be regulated through differential promoter control of the expression of the surface receptors for prolactin in different target tissues.
Thus rat decidual tissue possesses specific receptors for prolactin to which decidual luteotrophin locally produced can bind, thereby suggesting an auto/paracrine role for this substance.
This action appears to be mediated through prolactin receptors expressed by the cells.

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