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We propose that stem cell advocacy must engage in self-analysis to determine how to be maximally effective.
The results illustrate how stem cell research can translate into clinical practice in the IBC field.
Therefore, there is an urgent need for developing stem cell pathology as a discipline to facilitate stem cell research and regenerative medicine.
The adult stem cell population may be well suited for this task.
Understanding how the stem cells are behaving and giving rise to mature cells can be used to inform researchers on effective ways to design stem cell-based treatments.
Journal ArticleDOI
Gary Van Zant, Ying Liang 
202 Citations
Stem cell populations are likely to be a fruitful subject for studies of this type.
We argue that analysing accounts of how advisors respond to patient enquiries about stem cell treatments offers a window for examining the workings of the politics of hope within contemporary bioscience and biomedicine.
The cultured human epidermal stem cells could be used as a tool for studying stem cell biology and testing stem cell therapy.
The case study of stem cell service provider Beike Biotech illustrates how stem cell interventions take place in a large grey area, where narrow notions of ethics are blurred with and supplanted by broader notions of ethics, co-determined by estimations of socio-economic, political and cultural understandings of risk, opportunity and benefit.
The concept of “stemness” embraces two properties, which much coexist for a cell to be a stem …
Thus, stem cell therapy can be a valuable tool in regenerative medicine.
Stem-cell-based approaches could be employed in cell-replacement therapy or in drug treatments that encourage adult stem cells to migrate and activate at a site of injury or disease.
Synthetically analyzing three kinds of keywords, it can be concluded that application of stem cell transplantation technology to human disease therapy, especially research related on “embryonic stem cell” and “mesenchymal stem cell” is the orientation of all the stem cell research in the 21st century.
Stem Cell Bank and will be a useful resource for the international stem cell community.

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How does cell therapy work in terms of introducing new cells into tissues?
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What mechanism of cell competition is at work in aging epidermal cells?
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What mechanism of cell competition is at work in aging epidermal cells?
5 answers
How many stem cells are there in adipose tissue?\?
5 answers
Adipose tissue is a rich source of stem cells, particularly adipose-derived stem cells (ADSCs), which can be isolated from the stromal vascular fraction (SVF) of adipose tissue. The SVF contains a variety of stem cells, including multipotent and pluripotent stem cells, along with adipose stem/progenitor cells (ASCs). Compared to other sources like bone marrow, adipose tissue offers a less invasive and more abundant supply of stem cells, making it an attractive option for regenerative medicine and therapeutic applications. The number of stem cells in adipose tissue is relatively large, and they can be easily obtained through procedures like liposuction, which are minimally painful and ensure patient comfort. This abundance of stem cells in adipose tissue has led to extensive research on their potential use in tissue regeneration and various therapeutic interventions.
How many stem cells are there in adipose tissue?
5 answers
Adipose tissue contains a significant number of stem cells, particularly in the stromal vascular fraction (SVF). This fraction includes adipose stem/progenitor cells (ASCs), which are highly proliferative and possess the ability to differentiate into various cell types. The stromal-vascular cell fraction of adipose tissue is a rich source of multipotent and pluripotent stem cells, known as adipose-derived stem cells (ADSCs). These ADSCs have the potential to differentiate into cells of meso-, ecto-, and endodermal origin, making them versatile for various applications in regenerative medicine. Adipose-derived stem/stromal cells (ASCs) are abundant in fat tissue and have shown the capability to differentiate into adipose cells, chondrocytes, osteoblasts, neuronal cells, endothelial cells, and cardiomyocytes. The ease of harvesting adipose tissue and the abundance of stem cells make it a promising source for adult stem cells in regenerative medicine.
How many stem cells are there in bone marrow?
5 answers
Bone marrow is a rich source of stem cells, particularly mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs). MSCs are a heterogeneous population with regenerative potential, while HSCs are crucial for blood cell production. MSCs can be identified using specific cell markers like CD45−/CD73+/CD90+/CD105+ and CD45−/CD271+. These cells have the capability to differentiate into various cell types, making them valuable for tissue regeneration. In conditions like myelofibrosis, the interaction between MSCs and drugs like ruxolitinib can influence disease progression. Bone marrow, which accounts for 3-6% of body weight, produces around 500 billion blood cells daily. Stem cells in bone marrow, including pluripotent haemopoietic stem cells, are crucial for maintaining blood cell populations.
What is the transgelin family?
5 answers
The transgelin family comprises actin-binding proteins involved in various cellular processes such as cytoskeletal remodeling, cell contractility, and cell shape regulation. In mammals and Drosophila, three genes encode transgelin proteins, with overlapping expression patterns but distinct roles. Transgelin, also known as TAGLN, plays a crucial role in regulating cell motility, proliferation, and differentiation in different cell types, including smooth muscle cells. Studies have shown that TAGLN is associated with tumor development, with conflicting roles reported as both a tumor suppressor and a pro-tumorigenic factor in different cancer types. Additionally, TAGLN has been identified as a key regulator of ferroptosis in esophageal squamous cell carcinoma, influencing cell functions and pathways associated with this form of cell death. Moreover, TAGLN has been linked to the differentiation and migration of human bone marrow-derived stromal stem cells, highlighting its importance in regenerative medicine applications.
How stem cells extcellular vesicles can reduce high blood pressure and prevent endothelial dysfunction?
5 answers
Stem cell-derived extracellular vesicles (EVs) play a crucial role in reducing high blood pressure and preventing endothelial dysfunction. These EVs contain bioactive molecules like microRNAs, such as miR-146a and miR-126, which have shown significant effects in mitigating endothelial cell senescence, promoting angiogenesis, and protecting against vascular inflammation. Additionally, EVs from stem cells like adipose tissue stem cells and bone marrow mesenchymal stem cells have been found to improve vascular health by decreasing inflammatory markers, reducing oxidative stress, and enhancing vascular structure and function. Through their paracrine function and cargo of regulatory molecules, stem cell-derived EVs offer a promising therapeutic strategy for combating high blood pressure and endothelial dysfunction associated with vascular diseases.
What are the main types of cell injury?
4 answers
The main types of cell injury include ATP depletion, loss of calcium homeostasis, oxidative stress, damage to mitochondria, increased membrane permeability. Additionally, cell injuries can result from repeated bone-remodeling, thymic involution, and pathogen infections, leading to DNA changes in lymphoid cells. Electrical forces can also cause cell damage by disrupting membranes and altering biomolecule conformation. Mechanical stimulation beyond physiological thresholds can lead to cell injury through mechanisms like cell membrane deformation and failure, including mechanoporation. Furthermore, cellular injuries induced by various factors result in common morphological changes like apoptosis, with associated events such as changes in membrane permeability, elevated oxygen consumption rates, and DNA fragmentation.
Which way is the most efficent to deliver genes in human mesenchymal stem cells?
4 answers
The most efficient way to deliver genes in human mesenchymal stem cells (hMSCs) involves using mini-intronic plasmids containing the cytomegalovirus (CMV) promoter delivered with Lipofectamine 3000. This method has been shown to produce the highest transfection levels in hMSCs. Other approaches like robotic microinjection have also demonstrated high transfection efficiency, with microinjection showing around 60% efficiency. Additionally, lipid-based carriers have been highlighted as efficient vehicles for nucleic acid delivery to MSCs, emphasizing the importance of carrier selection in gene delivery systems. Furthermore, lipidoid nanoparticles have been developed to deliver mRNA into hMSCs effectively, showcasing successful neural-like differentiation through CRISPR-based gene knockdown. Overall, these findings underscore the significance of optimized delivery methods for gene modification in hMSCs to enhance their therapeutic potential.
Are hydras high-level plants?
5 answers
Hydras are not high-level plants; they are actually fascinating organisms belonging to the phylum Cnidaria, known for their regenerative abilities, aging research significance, and stem cell biology studies. Hydra's unique characteristics, such as their ability to regenerate extensively and decouple aging from their life history, make them valuable for understanding aging processes across different species. While often compared to plant systems, Hydra's simple body plan actually represents an animal prototype with stem cell lineages similar to Bilateria, showcasing properties that correspond to more complex animals. Additionally, Hydra is involved in information modeling and decision-support systems for improving irrigation practices in European Mediterranean agriculture, highlighting its diverse applications beyond plant-related studies.