scispace - formally typeset
Search or ask a question

How does diabetes affect mortality after a myocardial infarction? 

Best insight from top research papers

Diabetes is associated with increased mortality after a myocardial infarction (MI) . Patients with diabetes have a higher risk of in-hospital mortality and 1-year mortality compared to those without diabetes . The duration of diabetes is also a significant factor, with longer duration correlating with higher mortality risk . Patients with diabetes who are hospitalized for MI are more likely to have comorbidities and present with non-ST-segment elevation MI (NSTEMI) rather than ST-segment elevation MI (STEMI) . They also have a lower probability of receiving certain treatments, such as aspirin, nonaspirin antiplatelets, coronary angiography, and coronary revascularization . Diabetes is associated with a higher risk of sudden cardiac arrest (SCA) in patients hospitalized for ST-elevation MI, and it is also associated with a higher mortality risk in SCA patients . However, the recent temporal trend shows a decline in mortality in SCA patients, regardless of diabetes .

Answers from top 5 papers

More filters
Papers (5)Insight
Diabetes is associated with a higher risk of mortality after a myocardial infarction, according to the provided paper.
Diabetes is associated with a 52% higher hazard of all-cause 1-year mortality in patients hospitalized with acute myocardial infarction.
Diabetes is associated with a 52% higher hazard of all-cause 1-year mortality in patients hospitalized with acute myocardial infarction.
Diabetes mellitus is associated with an increased risk of in-hospital mortality and 1-year mortality in patients hospitalized with acute myocardial infarction (AMI). The risk of mortality increases with the duration of diabetes.
Diabetes is associated with worse prognosis and increased mortality in patients who undergo percutaneous coronary intervention (PCI) due to myocardial infarction (MI).

Related Questions

Why patients with diabetes mellitus are more prone to develop CVDs?4 answersPatients with diabetes mellitus (DM) are more prone to develop cardiovascular diseases (CVDs) due to several factors. The prevalence of CVD is higher in DM patients compared to the general population, with a 2 to 6 times increased risk. DM is an independent risk factor for atrial fibrillation (AF) and is frequently observed in patients with AF, further increasing their risk of stroke. Macrovascular and microvascular abnormalities in blood vessels, which are common complications of DM, contribute to the development of CVD. Additionally, the presence of DM reduces life expectancy and increases the risk of dying from coronary heart disease. The severity of CVD in DM patients can be measured using the Gensini score, which shows a significant positive association with glycated hemoglobin levels. Overall, the prothrombotic and inflammatory state of DM patients, along with the metabolic complications and vascular abnormalities associated with the disease, contribute to their increased susceptibility to CVDs.
How does diabetes affect the risk of stroke?5 answersDiabetes is associated with an increased risk of stroke, with people with diabetes having a 1.5-2 times higher risk compared to those without diabetes. The risk of stroke may differ according to sex, with a greater risk observed among women. Mechanisms associated with diabetes that lead to stroke include large artery atherosclerosis, cerebral small vessel disease, and cardiac embolism. Hyperglycemia also confers an increased risk for worse outcomes in people with acute ischemic stroke. Additionally, people with diabetes may have poorer post-stroke outcomes and a higher risk of stroke recurrence. Appropriate management of diabetes and other vascular risk factors can improve stroke outcomes and reduce the risk of recurrent stroke. Screening for diabetes following a stroke is recommended, and certain diabetes medications have demonstrated protection against stroke. Neurologists play a role in managing modifiable risk factors for stroke but are less involved in the direct management of diabetes.
Is metformin associated with a reduced risk of death in people with no type 2 diabetes?4 answersMetformin is not associated with a reduced risk of death in people with no type 2 diabetes. The studies focused on individuals with type 2 diabetes and examined the effects of metformin on various outcomes such as dementia, ischemic stroke, pneumonia, and cardiovascular events. The results consistently showed that metformin use was associated with lower risks of these specific conditions in individuals with type 2 diabetes. However, there were no studies included in the provided abstracts that specifically investigated the association between metformin use and the risk of death in people without type 2 diabetes. Therefore, based on the available information, there is no evidence to suggest that metformin reduces the risk of death in individuals without type 2 diabetes.
What is the effect of cannabis on myocardial infarction?5 answersCannabis has been found to have an effect on myocardial infarction (MI) by increasing vascular tone and sympathetic hormone secretion, which can lead to vasospasms in the coronary artery. This can potentially precipitate MI in individuals with underlying risk factors or cardiac anomalies. Cannabis consumption, particularly the synthetic component, has been associated with severe adverse effects, including diffuse coronary vasospasm and cardiac arrest. It has also been reported as a risk factor for acute coronary syndrome (ACS) and can trigger ST-segment elevation myocardial infarction (STEMI). Healthcare professionals should consider cannabis consumption as a possible cause of MI, especially in young patients with a susceptible social profile and educate patients about this emerging public health issue. The increasing use of cannabis worldwide necessitates awareness of its multifaceted effects on various organ systems, including the cardiovascular system.
What are the effects of diabetes on cancer survival?5 answersDiabetes has been found to have negative effects on cancer survival. In patients with colorectal and pancreatic cancer, pre-existing type 2 diabetes was associated with increased incidence of cachexia, higher weight loss, and reduced survival probability. Similarly, in various types of cancer including lung, digestive tract, leukemia, breast, and liver cancer, diabetes was associated with shorter overall survival. However, in breast cancer patients, the presence of diabetes did not significantly affect survival rates. On the other hand, in endometrial cancer patients, diabetes was associated with worse cancer-specific survival, progression or recurrence-free survival, and overall survival. These findings suggest that diabetes can have varying effects on cancer survival depending on the type of cancer.
How are cardiovascular diseases implicated in T2DM mortality?5 answersCardiovascular diseases are implicated in the mortality of patients with type 2 diabetes mellitus (T2DM). T2DM patients have a higher mortality rate compared to the general population, mainly due to excess mortality from coronary heart disease and cerebrovascular disease. The risk of death from cardiovascular diseases is higher among patients with early onset diabetes. In patients with end-stage renal failure (ESRF), cardiovascular mortality is significantly higher than in the general population. Left ventricular hypertrophy, heart failure, and arterial atheroma contribute to the increased cardiovascular morbidity and mortality in ESRF patients. Specific risk factors related to chronic renal failure and its treatment, such as hydroelectrolytic disorders, anemia, and elevated thrombogenesis factors, also contribute to the high cardiovascular morbidity and mortality in dialysis patients. Epigenetic modifications, specifically DNA methylation, play a role in the pathogenesis of cardiovascular diseases in diabetes. Monitoring specific vibrational spectral characteristics can predict mortality in cardiovascular diseases.

See what other people are reading

What is the inverted u theory of arousal and performance?
4 answers
The inverted U theory of arousal and performance suggests that there is an optimal level of arousal for task performance. According to this theory, performance on easy tasks peaks at higher arousal levels, while performance on difficult tasks follows an inverted U-shaped relationship with arousal, peaking at medium arousal levels. This theory is supported by studies that have examined the effect of arousal on motor skills. For simple motor tasks, high arousal is more advantageous, while for complex motor tasks, low arousal is more advantageous. Neurofeedback techniques have been used to shift an individual's arousal state towards the optimal level, resulting in improved task performance. The Yerkes-Dodson law, which describes the inverse U-shaped relationship between arousal and performance, is a fundamental principle underlying the inverted U theory.
What is the prevalence of peripheral arterial disease?
4 answers
The prevalence of peripheral arterial disease (PAD) varies across different regions. In the Veneto region of Northern Italy, the age-standardized mortality rate for PAD remained stable, contributing to 1.6% of all deaths recorded in the region. In a Swiss study of acute coronary syndrome (ACS) patients, 6.0% had PAD, and these patients had a higher rate of major adverse cardiac and cerebrovascular events (MACCE) compared to those without PAD. Worldwide, the estimated prevalence of PAD was 236 million people in 2015, with numbers continuing to rise. In China, the age-standardized prevalence of PAD increased from 1990 to 2019, with a higher prevalence in females. In Northern India, the prevalence of PAD was observed to be higher in elderly males with a low socioeconomic status.
How to design a photocatalyst using first principles?
4 answers
The design of photocatalysts using first principles involves several steps. First, the electronic and structural properties of the catalyst material are studied using density functional theory calculations. This helps in understanding the surface structure, electronic structure, work function, and charge transfer of the material. The adsorption energies of different metal atoms on the surface are analyzed to determine their stability and potential for catalytic activity. The performance of different metal atoms in enhancing specific reactions, such as hydrogen evolution and CO2 activation, is evaluated. Additionally, the band-edge potentials and optical absorption abilities of the material are considered to assess its suitability for photocatalytic water splitting. Theoretical calculations also help in understanding the effect of strain on the electronic and optical properties of the material, allowing for tunability. Overall, first principles calculations provide valuable insights for the design of efficient and high-performance photocatalysts.
What are the primary sources and pathways through which microplastics enter the natural environment?
5 answers
Microplastics enter the natural environment through various primary sources and pathways. The primary sources of microplastics include plastic waste disintegration, tire wear, industrial processes, textile washing, and personal care products. These sources release microplastics into the environment, where they can accumulate in rivers, lakes, oceans, sediments, wastewater, drinking water, and bottled water. The pathways through which microplastics spread include rivers, atmospheric circulation, and stormwater runoff. Rivers are major pathways for transporting microplastics from terrestrial areas into the ocean. Atmospheric circulation also plays a role in transporting microplastics between different environmental compartments. Stormwater carries microplastics from various sources, such as tire wear, artificial turf, fertilizers, and land-applied biosolids, into water bodies. These pathways contribute to the widespread distribution of microplastics in the environment.
What are the secondary metabolites of endophytic penicillium?
5 answers
Endophytic Penicillium fungi have been found to produce a variety of secondary metabolites. Penicillium crustosum was found to contain eight known secondary metabolites with antibacterial properties. Penicillium chrysogenum treated with sodium butyrate was found to have bioactive compounds including pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro, cyclotrisiloxane, hexamethyl, and quinoline, 1,2-dihydro-2,24-trimethyl. Mycophenolic acid was identified as the main contributor to the biological activity of an organic extract from a Penicillium endophyte. Penicillium sp. YT2019-3321, derived from Lonicera japonica, produced two previously unreported polyketides, (±)-chrysoalide B and penicidone E, with the latter showing cytotoxic activity against human pancreatic tumor cells. Penicillium roseopurpureum 1E4BS1 isolated from Astragalus angustifolius produced nine metabolites, including five new anthraquinone-type compounds.
Can ampk promote innate immunity?
4 answers
AMPK activation has been shown to promote innate immunity in multiple studies. AMPK activation restricted Zika virus (ZIKV) replication and evoked antiviral innate responses. Inhibition of AMPK increased the expansion of proinflammatory innate lymphoid cells (ILCs) after traumatic brain injury (TBI), while AMPK activation suppressed proinflammatory ILCs and increased the frequency of IL-10-expressing ILCs. Additionally, AMPK-dependent surveillance systems in Caenorhabditis elegans triggered innate immune responses against pathogenic attacks. These findings suggest that AMPK plays a crucial role in promoting innate immunity and can be targeted for the development of anti-viral therapies and modulation of cerebral immunity.
What is restitution?
5 answers
Restitution is a form of compensation for victims of criminal acts, where the perpetrator or a third party pays the victim or their family to restore their rights or property. It can involve returning stolen or improperly traded cultural property to its rightful owner. Restitution is not applicable to all types of crimes, and legal protection for victims is still an ongoing discourse. The concept of restitution aims to protect victims by fulfilling their rights that have been ignored. The mechanism for regulating restitution is not fully established in laws and regulations, making it difficult for victims to apply for restitution in cases of criminal acts. Restitution is also a legal institution that promotes the protection of human rights and freedoms, and it requires effective measures at the legislative and international cooperation levels. Overall, restitution is a means of providing compensation and restoring lost rights to victims of criminal acts or individuals who have lost cultural property.
How can water flux be improved in forward osmosis?
4 answers
Water flux in forward osmosis (FO) can be improved through various methods. One approach is to optimize the design of the spacer used in the FO membrane module. A study by Bahoosh et al. introduced a new spacer based on the concept of airfoils, which increased turbulency and water flux in the FO process. Another method is to use microgels as draw agents. Gao et al. found that poly(4-vinylpyridine) (P4VP) grafted to a poly(N-Isopropylacrylamide) (PNIPAAm) crosslinking network effectively drew water in FO. Additionally, the application of voltage in an electrically charged FO system can enhance water recovery. Kekre et al. developed an electrically charged FO system that improved water recovery by 39%. Furthermore, the performance of the FO membrane itself can be enhanced by modifying its structure. Nie et al. investigated the use of MXene nano-sheets in the interfacial polymerization process, which significantly improved the water flux of the FO membrane. These studies provide insights into different approaches for improving water flux in FO.
Eugenol as antidiabetic agent?
5 answers
Eugenol has been investigated for its potential as an antidiabetic agent. Studies have shown that eugenol administration can ameliorate diabetes features by improving lipid profile, oxidative status, insulin and glucose levels, sex hormone levels, liver markers, and pancreas histology. It also has antioxidant, anti-inflammatory, and anti-diabetic properties, which contribute to its therapeutic effects in diabetes. Additionally, eugenol has been found to lower blood glucose and insulin resistance, reduce muscle inflammation, and prevent muscle weakness and atrophy in a mouse model of diabetes. These findings suggest that eugenol may be a promising natural product for the prevention and management of diabetes. However, further research is needed to fully understand the mechanisms of action and potential clinical applications of eugenol as an antidiabetic agent.
How can noise in eeg be quantified?
4 answers
Noise in EEG can be quantified using various techniques. One approach is to estimate the noise parameters using the Kalman filter technique. Another method involves understanding the contamination from electromyogram (EMG) along the scalp and quantitatively estimating EMG noise in different EEG channels. Additionally, a quantitative signal quality assessment pipeline can be used to detect artifacts and provide a quantitative assessment of the raw EEG data. Another approach is to utilize multiscale entropy (MSE) analysis, which quantifies the complexity of the signal, to detect noise in EEG signals. Furthermore, a deep learning strategy can be employed to optimize quality assessment algorithms and remove noise from EEG signals. These methods provide different ways to quantify and remove noise in EEG signals, allowing for more accurate analysis and interpretation of the data.
How is the langmuir model used in adsorption and the process of getting the each component of the formula?
5 answers
The Langmuir model is used in adsorption to characterize the adsorption process and predict adsorption equilibria. It provides a simple and elegant method for describing the adsorption behavior of components on a surface. The Langmuir model can be extended to incorporate complexity, such as heterogeneity and cooperative effects among ligands and receptors. Different variations of the Langmuir model have been developed, including the fuzzy Langmuir adsorption equations and the multi-molecular layer Langmuir isothermal adsorption model. These models are used to determine the adsorption relationship, predict chromatographic elution curves, and estimate the isosteric heat of adsorption. The parameters of the Langmuir model, such as the binding free energy and saturation capacity, can be obtained through experimental measurements, computer simulations, and theoretical calculations.