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How does the free radical ageing theory explain the ageing process? 


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The free radical theory of aging suggests that the accumulation of oxidative damage caused by free radicals is a fundamental driver of cellular aging. This theory emphasizes the role of mitochondrial DNA (mtDNA) mutations and the accumulation of mtDNA deletions, which promote mitochondrial dysfunction and increase free radical production. Oxidative damage in the form of 8-oxodG DNA oxidative lesions has been observed to accumulate with age, supporting the free radical theory of aging . However, the theory has faced challenges and exceptions, leading to the proposal of an alternative perspective. The concept of Adaptive Homeostasis suggests that free radicals and oxidants are just one subset of stressors that organisms must cope with over their lifespans. This theory highlights the dynamic expansion and contraction of stress defense and repair systems, employing signal transduction pathways to generate inducible and enzymatic protection. Viewed as a component of Adaptive Homeostasis, the Free Radical Theory of Aging remains viable and robust .

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The paper discusses that the free radical theory of aging proposes that aging is caused by the accumulation of damage inflicted by reactive oxygen species (ROS). However, the paper also mentions that this theory has limitations and does not fully explain the aging process.
Open accessJournal ArticleDOI
Suka Aryana, Ra Tuty Kuswardhani 
15 May 2018
The free radical aging theory states that free radicals, produced during the oxidation process, cause cell and tissue destruction, leading to aging.
The free radical theory of aging suggests that the gradual accumulation of oxidative cellular damage, caused by free radicals, is a fundamental driver of cellular aging. This theory emphasizes the role of mitochondrial DNA mutations and the accumulation of mtDNA deletions in promoting mitochondrial dysfunction and increasing free radical production.
The Free Radical Theory of Ageing posits that free radicals and oxidants cause damage to cellular constituents over time, resulting in structural and functional problems that contribute to the ageing process.

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