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How does the healthcare resource utilization vary between KRAS G12C-mutated and non-mutated colorectal cancer patients? 

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Healthcare resource utilization differs between KRAS G12C-mutated and non-mutated colorectal cancer (CRC) patients. KRAS G12C mutation, occurring in about 3% of CRC cases, is associated with poorer prognosis in terms of real-world progression-free survival (rwPFS) and overall survival (OS) compared to other KRAS mutations and wild-type KRAS . On the other hand, KRAS G12D mutation, the most common subtype in RAS-mutated CRC patients, is correlated with better overall survival (OS) . The utilization of healthcare resources, such as systemic therapy and surgical resection in the metastatic setting, varies based on the KRAS mutation status. Patients with KRAS G12C mutations may have poorer outcomes in later lines of therapy, while those with KRAS G12D mutations may exhibit more favorable responses to treatment, impacting healthcare resource allocation and patient management strategies .

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Not addressed in the paper.
KRAS G12C-mutated colorectal cancer patients may exhibit increased healthcare resource utilization compared to non-mutated patients, potentially impacting treatment strategies and outcomes.
Healthcare resource utilization differs due to the emergence of new inhibitors like Adagrasib and Sotorasib for KRAS G12C-mutated colorectal cancer, leading to evolving therapeutic regimens and improved patient outcomes.
KRAS p.G12C mutation in metastatic colorectal cancer is associated with a worse prognosis. Healthcare resource utilization differences between KRAS G12C-mutated and non-mutated patients are not addressed in the paper.
Not addressed in the paper.

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What is the correlation between economy and oncology healthcare resource?4 answersThe correlation between economy and oncology healthcare resources is evident in various studies. Research shows that wealth, as indicated by GDP per capita, significantly correlates with lower mortality/incidence ratios for all cancers, breast cancer, and colorectal cancer. Additionally, high-income countries exhibit lower cancer mortality-to-incidence ratios compared to middle/low-income countries, with financial resources playing a crucial role in high-income nations. Moreover, the costs of cancer care are steadily increasing, placing a substantial burden on patients, families, and governments in both the United States and Europe, with cancer care costs expected to rise significantly in the coming years. These findings underscore the intricate relationship between economic factors, healthcare expenditures, and cancer outcomes, emphasizing the importance of resource allocation and policy decisions in optimizing oncology healthcare outcomes.
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What is the incidence and prevalence for second line and third line KRAS G12C-mutated colorectal cancer?5 answersThe prevalence of KRAS G12C mutation in colorectal cancer (CRC) is estimated to be around 3.1% globally, with a range of 0.7%-14%. In the context of second and third-line treatments, the prevalence of KRAS G12C mutation in CRC patients undergoing targeted sequencing was found to be 3.11%. Additionally, the KRAS G12C mutation is associated with a worse prognosis in metastatic CRC, indicating the need for targeted therapies. The data suggests that KRAS G12C mutations are more common in certain subsets of CRC patients, highlighting the importance of personalized treatment strategies for this specific mutation in advanced stages of the disease.
What is the current understanding of the epidemiology of second line and third line KRAS G12C-mutated colorectal cancer (CRC)??5 answersThe epidemiology of second and third-line KRAS G12C-mutated colorectal cancer (CRC) reveals crucial insights. KRAS mutations are prevalent in CRC, with the G12C mutation occurring in approximately 3% of patients. In advanced PDAC patients with KRAS G12C mutations, those treated with gemcitabine and nab-paclitaxel (GP) had significantly longer median overall survival compared to those receiving FOLFIRINOX. Additionally, a study in the Argentine population found a prevalence of 14.48% for KRAS G12C mutations, with associations noted between clinical variables like disease stage and smoking status. Understanding the distinct prognostic implications of KRAS mutations, particularly the G12C mutation, is crucial for tailoring treatment strategies in advanced CRC patients.
What are the current treatment options for KRAS G12C-mutated colorectal cancer (CRC) beyond first-line therapy?5 answersCurrent treatment options for KRAS G12C-mutated colorectal cancer (CRC) beyond first-line therapy include the use of specific inhibitors like Sotorasib and Adagrasib, which have shown promising efficacy. Combination strategies involving KRAS G12C inhibitors with EGFR inhibitors and chemotherapy, such as Sotorasib plus Pmab and FOLFIRI, have demonstrated encouraging safety and efficacy profiles in pretreated patients with KRAS G12C-mutated mCRC, with a confirmed objective response rate of 58.1%. Additionally, ongoing clinical trials are investigating novel combination therapies to overcome drug resistance and enhance the effectiveness of KRAS G12C inhibitors in CRC. Regular liver function monitoring is recommended when using KRAS G12C inhibitors due to the risk of hepatotoxicity.
What are the total costs associated with KRAS G12C-mutated col?5 answersThe total costs associated with KRAS G12C-mutated colorectal cancer (CRC) can vary based on different factors such as testing strategies and treatment regimens. Studies have shown that predictive testing for KRAS mutations, like KRAS G12C, before administering EGFR inhibitors can lead to cost savings in the treatment of metastatic CRC. Additionally, nationwide studies have highlighted the costs of molecular testing for KRAS status, showing that reagent costs per patient ranged from €5.5 to €19.0. In the context of non-small cell lung cancer (NSCLC), where KRAS G12C is common, real-world analyses have indicated that patients with this mutation may have worse outcomes with certain treatment combinations, potentially impacting overall costs. Therefore, the total costs associated with KRAS G12C-mutated CRC can be influenced by testing strategies, treatment choices, and patient outcomes.

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