scispace - formally typeset
Search or ask a question

How does the healthcare resource utilization vary between KRAS G12C-mutated and non-mutated colorectal cancer patients? 


Best insight from top research papers

Healthcare resource utilization differs between KRAS G12C-mutated and non-mutated colorectal cancer (CRC) patients. KRAS G12C mutation, occurring in about 3% of CRC cases, is associated with poorer prognosis in terms of real-world progression-free survival (rwPFS) and overall survival (OS) compared to other KRAS mutations and wild-type KRAS . On the other hand, KRAS G12D mutation, the most common subtype in RAS-mutated CRC patients, is correlated with better overall survival (OS) . The utilization of healthcare resources, such as systemic therapy and surgical resection in the metastatic setting, varies based on the KRAS mutation status. Patients with KRAS G12C mutations may have poorer outcomes in later lines of therapy, while those with KRAS G12D mutations may exhibit more favorable responses to treatment, impacting healthcare resource allocation and patient management strategies .

Answers from top 5 papers

More filters
Papers (5)Insight
Not addressed in the paper.
KRAS G12C-mutated colorectal cancer patients may exhibit increased healthcare resource utilization compared to non-mutated patients, potentially impacting treatment strategies and outcomes.
Healthcare resource utilization differs due to the emergence of new inhibitors like Adagrasib and Sotorasib for KRAS G12C-mutated colorectal cancer, leading to evolving therapeutic regimens and improved patient outcomes.
KRAS p.G12C mutation in metastatic colorectal cancer is associated with a worse prognosis. Healthcare resource utilization differences between KRAS G12C-mutated and non-mutated patients are not addressed in the paper.
Not addressed in the paper.

Related Questions

What is the correlation between economy and oncology healthcare resource?4 answersThe correlation between economy and oncology healthcare resources is evident in various studies. Research shows that wealth, as indicated by GDP per capita, significantly correlates with lower mortality/incidence ratios for all cancers, breast cancer, and colorectal cancer. Additionally, high-income countries exhibit lower cancer mortality-to-incidence ratios compared to middle/low-income countries, with financial resources playing a crucial role in high-income nations. Moreover, the costs of cancer care are steadily increasing, placing a substantial burden on patients, families, and governments in both the United States and Europe, with cancer care costs expected to rise significantly in the coming years. These findings underscore the intricate relationship between economic factors, healthcare expenditures, and cancer outcomes, emphasizing the importance of resource allocation and policy decisions in optimizing oncology healthcare outcomes.
What is the benefit of IV vs oral recombinant monoclonal antibody for KRAS colorectal cancer?5 answersThe benefit of intravenous (IV) administration of a recombinant monoclonal antibody for KRAS colorectal cancer lies in its efficacy and safety profile. Studies have shown that IV administration of antibodies like Panitumumab (Pmab) in combination with other agents like Niraparib can lead to considerable antitumor activity in patients with RAS wildtype metastatic colorectal carcinoma (mCRC). Additionally, a fully humanized anti-EGFR monoclonal antibody, SCT200, administered intravenously, demonstrated favorable safety, pharmacokinetics, and efficacy in patients with wild-type KRAS/NRAS/BRAF mCRC. These findings suggest that IV administration of recombinant monoclonal antibodies can offer effective treatment options for KRAS colorectal cancer patients, potentially improving outcomes and providing a promising therapeutic approach.
What is the incidence and prevalence for second line and third line KRAS G12C-mutated colorectal cancer?5 answersThe prevalence of KRAS G12C mutation in colorectal cancer (CRC) is estimated to be around 3.1% globally, with a range of 0.7%-14%. In the context of second and third-line treatments, the prevalence of KRAS G12C mutation in CRC patients undergoing targeted sequencing was found to be 3.11%. Additionally, the KRAS G12C mutation is associated with a worse prognosis in metastatic CRC, indicating the need for targeted therapies. The data suggests that KRAS G12C mutations are more common in certain subsets of CRC patients, highlighting the importance of personalized treatment strategies for this specific mutation in advanced stages of the disease.
What is the current understanding of the epidemiology of second line and third line KRAS G12C-mutated colorectal cancer (CRC)??5 answersThe epidemiology of second and third-line KRAS G12C-mutated colorectal cancer (CRC) reveals crucial insights. KRAS mutations are prevalent in CRC, with the G12C mutation occurring in approximately 3% of patients. In advanced PDAC patients with KRAS G12C mutations, those treated with gemcitabine and nab-paclitaxel (GP) had significantly longer median overall survival compared to those receiving FOLFIRINOX. Additionally, a study in the Argentine population found a prevalence of 14.48% for KRAS G12C mutations, with associations noted between clinical variables like disease stage and smoking status. Understanding the distinct prognostic implications of KRAS mutations, particularly the G12C mutation, is crucial for tailoring treatment strategies in advanced CRC patients.
What are the current treatment options for KRAS G12C-mutated colorectal cancer (CRC) beyond first-line therapy?5 answersCurrent treatment options for KRAS G12C-mutated colorectal cancer (CRC) beyond first-line therapy include the use of specific inhibitors like Sotorasib and Adagrasib, which have shown promising efficacy. Combination strategies involving KRAS G12C inhibitors with EGFR inhibitors and chemotherapy, such as Sotorasib plus Pmab and FOLFIRI, have demonstrated encouraging safety and efficacy profiles in pretreated patients with KRAS G12C-mutated mCRC, with a confirmed objective response rate of 58.1%. Additionally, ongoing clinical trials are investigating novel combination therapies to overcome drug resistance and enhance the effectiveness of KRAS G12C inhibitors in CRC. Regular liver function monitoring is recommended when using KRAS G12C inhibitors due to the risk of hepatotoxicity.
What are the total costs associated with KRAS G12C-mutated col?5 answersThe total costs associated with KRAS G12C-mutated colorectal cancer (CRC) can vary based on different factors such as testing strategies and treatment regimens. Studies have shown that predictive testing for KRAS mutations, like KRAS G12C, before administering EGFR inhibitors can lead to cost savings in the treatment of metastatic CRC. Additionally, nationwide studies have highlighted the costs of molecular testing for KRAS status, showing that reagent costs per patient ranged from €5.5 to €19.0. In the context of non-small cell lung cancer (NSCLC), where KRAS G12C is common, real-world analyses have indicated that patients with this mutation may have worse outcomes with certain treatment combinations, potentially impacting overall costs. Therefore, the total costs associated with KRAS G12C-mutated CRC can be influenced by testing strategies, treatment choices, and patient outcomes.

See what other people are reading

What is Mendelian genetics?
4 answers
Mendelian genetics, established by Gregor Mendel in the 19th century, is the study of genetic inheritance patterns in organisms based on the principles of heredity he proposed. Mendel's meticulous experimental design and observations led to the formulation of the fundamental laws of inheritance, known as Mendelian rules. These rules serve as the cornerstone of genetics, guiding our understanding of how traits are passed down from parents to offspring. Furthermore, the concept of Mendelian randomization, a modern epidemiological method, utilizes genetic variants as instrumental variables to investigate causal relationships between modifiable exposures and outcomes, building upon Mendel's laws of inheritance. Mendelian genetics continues to play a crucial role in unraveling the complexities of genetic inheritance and its implications for various fields of study.
How effective is intravitreal injection of anti-VEGF drugs in delaying visual deterioration in patients with diabetic macular edema?
5 answers
Intravitreal injection of anti-VEGF drugs, such as ranibizumab, aflibercept, and brolucizumab, has shown effectiveness in delaying visual deterioration in patients with diabetic macular edema (DME). Studies have demonstrated that anti-VEGF therapy leads to significant improvements in best-corrected visual acuity (BCVA) and reduction in central macular thickness (CMT) in DME patients, thereby delaying visual impairment. Additionally, the use of sustained-release devices like the Port Delivery System and biodegradable drugs aims to reduce the frequency of injections and prolong the drug's effect, further enhancing the treatment outcomes for DME. Overall, intravitreal anti-VEGF therapy has proven to be safe and effective in managing DME, highlighting its role in preserving vision and preventing visual deterioration in affected individuals.
What are the weaknesses of establishing Filipino food cuisines in California?
5 answers
Establishing Filipino food cuisines in California faces challenges due to historical and social contexts. The economic struggles and racial politics faced by Filipino immigrants in the U.S. hindered their integration and acceptance. Additionally, the complexities of Filipino-American legal status and the conflicts with local nativists and agribusiness interests created barriers to full assimilation and acceptance. Moreover, the lack of consideration for Filipinos in existing racial categories and the conflicting interests of different societal groups further complicate the establishment of Filipino food cuisines in California. These historical and social challenges highlight the difficulties in promoting and popularizing Filipino cuisine in California, reflecting broader issues of acceptance and integration faced by Filipino immigrants in the U.S.
Is competition or collaboration a better strategic choice for businesses operating in a permacrisis world?
5 answers
In a permacrisis world, businesses face the dilemma of choosing between competition and collaboration. Research suggests that a balance between competition and collaboration is crucial. While competition can drive innovation and efficiency, collaboration is essential for resilience and resource optimization. The interconnected nature of global challenges, such as the COVID-19 pandemic, highlights the importance of collaborative approaches in managing crises effectively. Coopetition, a concept involving simultaneous cooperation and competition with competitors, has emerged as a strategic choice for businesses to navigate complex and uncertain environments. By engaging in both internally and externally focused coopetition, firms can develop new knowledge-based resources and capabilities, enhancing their competitiveness while mitigating risks associated with opportunistic behaviors. Ultimately, a strategic blend of competition and collaboration, exemplified by coopetition, seems to offer a promising approach for businesses in a permacrisis world.
What is selective breeding?
5 answers
Selective breeding is a method that involves intentionally choosing individuals with desired traits to be parents of the next generation, aiming to enhance specific characteristics in subsequent offspring. This technique has been successfully applied across various species, including flies, corals, rabbits, zebrafish, and tea plants. By selectively breeding for extreme phenotypes, researchers can explore the genetic networks influencing targeted traits, discover correlated responses of traits with shared genetic architecture, and identify naturally occurring genomic variants and gene expression changes. Selective breeding has been shown to increase stress tolerance, growth speed, meat output, disease resistance, and bioactive ingredient contents in different organisms. It is a valuable tool for studying genetic and developmental resilience, as well as for conservation efforts in the face of challenges like climate change.
Consumer preferences affecting checkout abandonment?
4 answers
Consumer preferences play a crucial role in checkout abandonment in online shopping. Various factors influence this behavior, such as consumers using shopping carts for research and entertainment purposes, having abstract mindsets leading to higher purchase intentions, waiting for lower prices impacting hesitation at checkout and subsequent abandonment, and the relationship between research purpose, entertainment purpose, perceived cost, perceived risk, transaction inconvenience, and abandonment being partially mediated by pre-decisional conflict. Additionally, the development of machine learning systems can predict checkout outcomes based on customer activity, aiding merchants in reducing abandonment rates and making informed decisions. Understanding these consumer preferences is essential for online retailers to implement strategies that reduce checkout abandonment and enhance the overall shopping experience.
What are new trends or future of object detection?
5 answers
The future of object detection lies in advancements such as Future Object Detection, which focuses on predicting bounding boxes for objects in future video frames. This involves capturing temporal, kinematic, semantic, and geometric patterns using end-to-end methods like detection transformers. Additionally, the integration of deep learning methods, particularly convolutional neural networks (CNNs) and transformer-based detectors, has revolutionized object detection by eliminating the need for hand-crafted feature extraction processes. These models show superior real-time performance and accuracy, paving the way for set prediction techniques and enhanced detection modes. The continuous evolution of algorithms like R-CNN, fast R-CNN, faster R-CNN, YOLO, corner net, and NAS further propels object detection towards higher precision, reduced computational complexity, and faster detection speeds.
What is the difference between free electronics activities and wave electronics activities?
4 answers
Free electronics activities involve accelerating charged particles using methods like plasma wave accelerators and inverse free electron lasers, where electrons are accelerated by an intense laser field and a static magnetic field, leading to strong acceleration and ejection tendencies when using a focused laser beam. On the other hand, wave electronics activities focus on decentralized trust in authorization systems, like the WAVE framework, which ensures that permissions cannot be modified or seen by central services, allowing participants to autonomously delegate permissions securely. WAVE employs cryptographic enforcement, novel encryption protocols, and untrusted scalable storage solutions to protect permissions while offering competitive performance to traditional centralized systems. Both types of activities showcase innovative approaches in their respective fields, with free electronics emphasizing particle acceleration and wave electronics emphasizing secure decentralized authorization.
How do spectrometric techniques contribute to the detection and prevention of food fraud?
4 answers
Spectrometric techniques play a crucial role in detecting and preventing food fraud by providing rapid, non-destructive, and cost-effective means of analyzing food authenticity. These techniques, such as hyperspectral imaging, NMR, Raman, IR, UV, visible, fluorescence, and X-ray-based methods, offer efficient ways to verify the quality and origin of food products. By utilizing advanced spectroscopic methods in combination with chemometric tools, it becomes possible to extract relevant information, handle complex data, and ensure the accuracy of food analysis. The integration of spectrometric techniques with specialized algorithms and machine learning models further enhances the ability to differentiate between pure and adulterated food products, such as olive oil, even in challenging environments. Overall, the application of spectrometric techniques in food analysis contributes significantly to safeguarding consumer health, ensuring product quality, and combating fraudulent practices in the food industry.
How does the choice of coding method affect the accuracy and reliability of qualitative analysis?
5 answers
The choice of coding method significantly impacts the accuracy and reliability of qualitative analysis. Coding is a fundamental step in qualitative research, involving the systematic organization and interpretation of data. Different coding techniques, such as open coding or using software tools like QualCoder, influence the depth and rigor of the analysis process. Intercoder reliability, as demonstrated through techniques like the Many Facet Rasch Model (MFRM), plays a crucial role in ensuring consistency and trustworthiness in qualitative data analysis. The method chosen for coding can affect the transparency, efficiency, and overall quality of the analysis, ultimately impacting the validity of the findings and the development of theory in qualitative research.
What is the criteria for diagnosis of DKA?
4 answers
The diagnostic criteria for Diabetic Ketoacidosis (DKA) include elevated blood glucose levels, metabolic acidosis with a pH <7.3, serum bicarbonate <18 mEq/L, and the presence of ketones in the blood or urine. Additionally, anion gap metabolic acidosis is a key indicator for diagnosing DKA. Other factors such as elevated beta-hydroxybutyrate levels, decreased serum bicarbonate, and glucose levels >200 mg/dL are also considered in the diagnosis of DKA. It is crucial to differentiate DKA from other conditions like hyperosmolar hyperglycemic syndrome (HHS) and euglycemic DKA to ensure accurate diagnosis and appropriate management.