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How fast do antibiotics work on lung infection?

Respiratory tract infections

Cystic fibrosis

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Journal Article•DOI Optimal antibiotic therapy in the management of the lung of the critically ill Jason A. Roberts, Robert J. Boots, Jeffrey Lipman - Show less +2 more 01 Nov 2010-Current Respiratory Medicine Reviews	For these antibiotics, high doses in the first 24-48 hours of treatment may be required to maximise penetration into the lung.
Open access•Journal Article•DOI Sequential Inhalational Tobramycin-Colistin-Combination in CF-Patients with Chronic P. Aeruginosa Colonization - an Observational Study. Joachim Riethmüller, Gloria Herrmann, Ute Graepler-Mainka, Dorothea Hellwig, H.-E. Heuer, S Heyder, Holger Köster, Birte Kinder, Kristina Kröger, Klaus Paul, Krystyna Poplawska, Volker Melichar, Christina Smaczny, Uwe Mellies - Show less +13 more 31 Aug 2016-Cellular Physiology and Biochemistry 14 Citations	The results indicate that treatment with inhaled antibiotics, sequentially combined, was very well tolerated by most patients and may have a beneficial effect, even if transitory on lung function and respiratory symptoms.
Journal Article•DOI Penetration of Antibiotics into Respiratory Secretions James E. Pennington 01 Jan 1981-Clinical Infectious Diseases 206 Citations	Optimal methods of antibiotic therapy for lung infection may depend on the specific minimal inhibitory concentration for the infecting organism.
Journal Article•DOI Challenges with current inhaled treatments for chronic Pseudomonas aeruginosa infection in patients with cystic fibrosis Peter Greally, Paul Whitaker, Daniel Peckham - Show less +2 more 09 Mar 2012-Current Medical Research and Opinion 14 Citations	Findings: Antibiotics form a central part of the treatment regimens for chronic Pa lung infection.
Open access•Reference Entry•DOI Delayed antibiotics for respiratory infections Geoffrey Spurling, Chris Del Mar, Liz Dooley, Ruth Foxlee, Rebecca Farley - Show less +4 more 18 Jul 2007-Cochrane Database of Systematic Reviews 254 Citations	Delaying antibiotics seems to have little advantage over avoiding them altogether where it is safe to do so.

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