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We found a nonlinear association between platelet count and long-term mortality.
Increased platelet activity was associated with decreased bleeding risk, but only in patients with low platelet counts.
Determining the etiology for the low platelet count is important for the implementation of appropriate management.
A careful history helps reveal the chronicity of the low platelet count as well as prior bleeding episodes and new medications or infection.
Based on the results of this study, for patients with hematological improvement, recovery of platelet count by the second cycle of therapy can be used as an early predictive marker of improved survival and an increased response rate.

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