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How long do serotonin receptors take to heal? 

Serotonergic
5-HT receptor
Serotonin
Hippocampus
Serotonin uptake

Answers from top 10 papers

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Papers (10)Insight
Open access•Journal Article•DOI
A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus
Xiaoying Lu, Alasdair M. Barr, Jefferson W. Kinney, Pietro Paolo Sanna, Bruno Conti, M. Margarita Behrens, Tamas Bartfai 
18 Jan 2005-Proceedings of the National Academy of Sciences of the United States of America
132 Citations
Although the acute effect of selective serotonin reuptake inhibitors in elevating synaptic serotonin concentrations is well known, the clinical amelioration of depressive symptoms requires 14-21 days of treatment, suggesting that numerous other rearrangements of function in the CNS must take place.
Journal Article•DOI
The effect of kainate on protein kinase C, GABA, and the uptake of serotonin in the rabbit retina in vivo
Neville N. Osborne, Robert J. McCord, John P. M. Wood 
01 Jun 1995-Neurochemical Research
15 Citations
After seven days the GABA/serotonin amacrine cells cannot take up exogenous serotonin suggesting that all of these neurons are irreversibly damaged.
Open access•Journal Article
Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part I: Synaptosomal uptake and tissue concentrations.
Karen E. Sabol, Robert Lew, Jerry B. Richards, G L Vosmer, L S Seiden 
01 Feb 1996-Journal of Pharmacology and Experimental Therapeutics
113 Citations
These results indicate that a high-dose MDMA regimen results in long-lasting depletions of serotonin.
Journal Article•DOI
Cholesterol-lowering therapy evokes time-limited changes in serotonergic transmission
Jan Vevera, Zdenĕk Fisar, Tomáš Kvasnička, Hanus Zdenek, Lucie Stárková, Richard Ceska, Hana Papezova 
28 Feb 2005-Psychiatry Research-neuroimaging
75 Citations
These data indicate that long-term therapy has different effects on serotonin transmission from short-term (1- to 2-month) therapy.
Journal Article•DOI
Functional evidence that chronic drugs induce adaptive changes of central autoreceptors regulating serotonin release.
Guido Maura, Maurizio Raiteri 
27 Jan 1984-European Journal of Pharmacology
28 Citations
The results indicate that, after long-term blockade or stimulation, serotonin autoreceptors become respectively hyper- or hyposensitive towards serotonin.
Journal Article•DOI
A crustacean serotonin receptor: cloning and distribution in the thoracic ganglia of crayfish and freshwater prawn.
Maria A. Sosa, Nadja Spitzer, Donald H. Edwards, Deborah J. Baro, Deborah J. Baro 
07 Jun 2004-The Journal of Comparative Neurology
74 Citations
We also observed receptors that did not possess counterpart 5‐HT staining, suggesting that these may also mediate long‐term neurohormonal functions of serotonin.
Open access•Journal Article•DOI
Internalization and recycling of 5-HT2A receptors activated by serotonin and protein kinase C-mediated mechanisms
Samarjit Bhattacharyya, Sapna Puri, Ricardo Miledi, Mitradas M. Panicker 
29 Oct 2002-Proceedings of the National Academy of Sciences of the United States of America
88 Citations
Our study suggests that 5-HT2A receptors internalize and return to the surface after both serotonin- and PKC-mediated processes.
Journal Article•DOI
Multiple mechanisms of serotonin 5-HT2 receptor desensitization.
Shafiqur Rahman, Richard S. Neuman 
20 Jul 1993-European Journal of Pharmacology
42 Citations
We conclude that serotonin 5-HT2 receptors both induce and undergo several forms of desensitization.
Open access•Journal Article•DOI
Serotonin Promotes Development and Regeneration of Spinal Motor Neurons in Zebrafish.
Antón Barreiro-Iglesias, Karolina S. Mysiak, Angela L. M. Scott, Michell M. Reimer, Yujie Yang, Catherina G. Becker, Thomas Becker 
03 Nov 2015-Cell Reports
60 Citations
Pharmacological manipulations and receptor knockdown indicate that serotonin acts at least in part via 5-HT1A receptors.
Journal Article•DOI
Serotonin receptors in hippocampus and frontal cortex
Philip Seeman, Karen Westman, Donald V. Coscina, J.J. Warsch 
29 Aug 1980-European Journal of Pharmacology
88 Citations
These data support previous suggestions that supersensitivity develops specifically in serotonin receptors following afferent denervation.

Related Questions

How long do serotonin receptors take to heal?5 answersSerotonin receptors can exhibit varying recovery times based on the specific conditions and age. Studies have shown that the recovery of 5-HT2 receptors in the frontal cortex of rats can differ between mature and senescent individuals, with senescent rats displaying a slower recovery process. Additionally, the healing process of serotonin neurons in rats treated with MDMA indicated a significant reduction in neuronal markers initially, followed by a gradual recovery over time, with some animals showing enduring deficits even after a year. Furthermore, the effects of S(2)-receptor blockers on collagen-induced injuries in tendons demonstrated a significant impact on collagen turnover and scar tissue organization during the early stages of healing. These findings collectively suggest that the healing duration of serotonin receptors can vary depending on the specific circumstances and age-related factors.
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