How many amino acids are present in proinsulin?
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10 Citations | In summary, these studies indicate that the major site of glycation in proinsulin, like insulin, is the amino terminal Phe(1) residue. |
We have identified a 13 amino acid peptide of proinsulin (amino acids 24–36) that bears marked similarity to a peptide of GAD65 (amino acids 506–518) (G. Rudy, unpublished). | |
15 Citations | The deduced complete amino acid sequence indicates that the precursor molecule consists of 31 amino acids as the signal peptide and 197 amino acids of prolactin, in which two amino acids were found to be different from the amino acid sequence previously published elsewhere. |
48 Citations | In porcine proinsulin, the major antigenic determinant appears to be a hydrophobic region within the 41–54 amino acid sequence. |
22 Citations | The difference spectrum can be interpreted as being due to approximately 6 additional amino acids in theα-helix and 9 additional amino acids in theβ-structure in reduced proinsulin, all 15 being in random coil state in the separated chains. |
12 Citations | Since with this method we can determine over 40 physiological amino acids with a very good resolution, trace amounts of amino acids can also be determined. |
119 Citations | The yield of proinsulin in this system is more than twice the amount produced by using a 1007 amino acid-long beta-galactosidase gene for fusion. |
16 Citations | Proteolysis of the protein preparations obtained with the use of two enzymes was more favourable, particularly due to the quantity of free amino acids in and amino acids composition of the hydrolysates. |
This result indicated that the isolated proinsulin mRNA consisted of two types of proinsulin I mRNA and proinsulin II mRNA in approximately equal amounts. | |
39 Citations | The extent of in vivo conversion of proinsulin to metabolites may enhance the biological activity of proinsulin and, thus, have physiological, pathophysiological, and therapeutic significance. |