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How many amino acids are there in growth hormone? 

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The deduced amino acid sequence shows a putative signal peptide of 17 amino acids, suggesting that the mature hormone consists of 187 amino acids.
The deduced amino acid sequence shows two possible sites for signal peptide cleavage, suggesting that the mature forms of yellow tail growth hormone consist of 185 or 187 amino acids.
However, these peptides have only weak activity compared to native growth hormone, suggesting that additional amino acid residues N-terminal to position 95 are required for full biologic activity.
The evidence suggests that the availability of a single amino acid, valine, plays a regulatory role in the synthesis of a specialized cellular product and that growth hormone acts at some level to alter the availability of this essential amino acid.
Recent findings indicate that excitatory amino acids (EAAs) can modulate growth hormone (GH) secretion in several mammalian species in vivo and in vitro.
Deletion of all the amino acids except the 10 essential amino acids plus alanine resulted in a decreased weight gain to about 1/3 normal; indicating that although all the other amino acids could be synthesized, one or more of the dispensable amino acids may be required for maximal growth.
Incubation of the isolated diaphragm of the hypophysectomized rat with growth hormone also increases the incorporation of labeled amino acids into the protein of the It is not likely, however, that this apparent increase in the rate of muscle protein synthesis can be attributed to the action of growth hormone on amino acid transport.
Changes in a-aminoisobutyric acid distribution after growth hormone administration are therefore taken to mean a change in amino acid transport into cells (5).
This improved nitrogen retention is also reflected in the significantly low blood urea nitrogen levels in the recombinant human growth hormone group, which represents the efficient utilization of the infused amino acids for synthesis of proteins.
These findings suggest that growth hormone stimulates the transport of some, but not all, naturally occurring amino acids as well as that of the nonmetabolizable amino acid AIB.

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