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We found that most neurons that die do so within a maximal interval of 5 d after their birth, irrespective of the age of genesis or of the cell type.
We estimate that 10% to 70% of the neurons generated during the feeding larval stage degenerate within 24 h of their birth.
The wiring of the brain is almost as important as the number of neurons in the brain at birth, as this will ensure the preservation of those of most use.
The very same cells that give birth to new neurons also seem to nurture their maturation and support their function.
These results also contribute evidence that neurochemical evolution of the striatal neuronal populations is not complete at birth in humans.
This study indicates that the anatomical maturation of spines on the alpha and beta neurons is not temporally coincident from birth to 30 weeks.

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What are some articles that explain the importance of the vagus nerve in microbiota-gut-brain axis?
4 answers
The vagus nerve plays a crucial role in the microbiota-gut-brain axis, as highlighted in various research articles. Studies have shown that the vagus nerve facilitates communication between the gut microbiota and the brain. It has been discovered that the vagus nerve modulates appetite, influences host feeding behavior, and controls metabolic functions through interactions with the gut microbiota. Additionally, research has demonstrated that the vagus nerve relays the effects of stress-induced gut microbiome changes on brain functions and behavior, affecting neurotransmission pathways and neuroinflammation. The interconnected pathways of the microbiota-gut-brain axis, particularly involving the vagus nerve, are essential in understanding how gut microbes impact various physiological and pathological conditions, including mood disorders and metabolic disorders.
Is the importance of division orientation in neurogenesis controversial?
5 answers
The importance of division orientation in neurogenesis is indeed a topic of debate in the scientific community. While some studies emphasize the critical role of spindle orientation in determining the fate of neural progeny, others suggest that the relationship between cleavage plane orientation and daughter cell fate is complex and not fully understood. Research has shown that disruptions in mitotic spindle orientation can lead to defects in cell proliferation and cell fate determination during neurogenesis. The controversy lies in the varying interpretations of how spindle orientation influences the balance between symmetric and asymmetric cell divisions, ultimately impacting the generation of neurons and glial cells in the developing brain. Further investigations are needed to fully elucidate the precise mechanisms and significance of division orientation in neurogenesis.
What are drivers for innovation?
4 answers
Drivers for innovation encompass various factors that stimulate and facilitate innovative processes within organizations. These drivers include responses to client needs, employees' intrinsic motivation to innovate, user engagement, formal and informal organizational practices, the influence of experts and leaders, and continuous upskilling. Additionally, public institutions and government-led incentives play a crucial role in driving research and development efforts, especially during events like the COVID-19 pandemic. Social enterprises focus on business model innovation to address social issues, with drivers identified at environmental, organizational, and individual levels. Studies also highlight indicators such as market size, early-stage incentives, non-monetary incentives, and public institutions as essential drivers of innovation at both organizational and individual levels. These diverse drivers collectively contribute to fostering a culture of innovation and enhancing organizational performance.
What are the current trends and innovations in language teaching during the 21st century?
5 answers
Current trends and innovations in language teaching during the 21st century include the integration of digital competences, the use of ICTs to enhance learning processes, and the shift towards more interactive and student-centered teaching strategies. Strategies such as creative task-based learning, blended learning, collaborative approaches, and flipped learning are being adopted to address the challenges faced in language education. Additionally, the emphasis is on preparing teachers with the necessary skills to effectively teach languages in the digital age. The incorporation of online educational platforms and tools is also being explored to improve ESL classes. Overall, the focus is on creating a dynamic and engaging learning environment that caters to the needs and preferences of modern students while leveraging technology to enhance language acquisition.
How effective are values education programs with stories in promoting democratic attitudes among students?
5 answers
Values education programs utilizing stories have shown effectiveness in promoting democratic attitudes among students. Storytelling interventions, when engaging students to reflect on experiences and values, can lead to deeper insights and behavioral changes. Reflective picture storybook media has been found to significantly enhance the democratic character of elementary school students, aiding in the internalization of democratic virtues from an early age. Additionally, Citizenship Education plays a crucial role in instilling democratic values by embedding them in lesson plans, fostering unity, and assessing independence attitudes, with teachers serving as role models for students. These approaches highlight the importance of incorporating storytelling and reflective media in values education programs to effectively nurture democratic values among students.
Why does ideology when entering in politics tends to moderate ?
5 answers
Ideology tends to moderate in politics due to various factors. Research suggests that ideological moderation enhances a party's perceived competence, making it more willing to compromise and realistic in achieving goals. Additionally, in electoral models, candidates may moderate their policy preferences to signal their ideologies effectively to voters, especially when candidates have overlapping types. Furthermore, individuals with a genetic predisposition towards seeking new experiences are more likely to lean liberal politically, especially when exposed to diverse social contexts. This moderation in ideology is crucial for democratic representation, as it can lead to increased support from voters and facilitate policy implementation.
Which reactive astrocyte marker has been shown to increase in expression in RhoAnesKO mice?
6 answers
The question inquires about the increase in expression of a specific reactive astrocyte marker in RhoAnesKO mice. However, upon reviewing the provided contexts, there is no direct mention of a mouse model specifically referred to as "RhoAnesKO" nor is there a direct reference to the increase in expression of a reactive astrocyte marker in such a model. This indicates a potential misunderstanding or misinterpretation of the data presented in the contexts. To address the question with the information available, it's important to note that the contexts discuss various aspects of reactive astrocytes, their markers, and the role of different genes and pathways in their reactivity and function. For instance, STAT3 signaling in reactive astrocytes is crucial for proper glial scar formation and involves the regulation of cell migration and dynamics, with implications for astrocyte reactivity in conditions like spinal cord injury. Other studies have explored the role of different factors and conditions that affect astrocyte reactivity, such as the expression of GFAP and vimentin, the involvement of Sox2 in reactive astrocyte proliferation, and the impact of signaling pathways like Notch1–STAT3–ETBR on astrocyte proliferation. Additionally, the expression of TSPO in reactive astrocytes has been investigated as a marker of neuroinflammation, and the role of astrocyte-derived E2 in reactive astrogliosis has been highlighted. Furthermore, the impact of molecular adaptors like Rai on astrocyte function and reactivity has been studied, as well as the effects of 4R tau in astrocytes, and the role of the transcription factor SRF in maintaining astrocytes in a non-reactive state. Given the absence of specific information about RhoAnesKO mice and reactive astrocyte markers in the provided contexts, it's not possible to directly answer the question as posed. The contexts instead offer a broad overview of the mechanisms and markers associated with astrocyte reactivity and the complex interplay of genetic and molecular factors that influence this process across different studies and models.
What specific factors influence the poor comprehension of math among highschool students?
5 answers
Factors influencing poor comprehension of math among high school students include students' attitudes, inadequate teaching strategies, lack of resources, under-qualified teachers, poor study environments, and insufficient parental involvement. Additionally, teacher-student relationships, the use of technical terms beyond learners' understanding, teacher absenteeism, inadequate time for math classes, and parents' failure to provide necessary learning materials or monitor progress contribute to low math performance. Moreover, government involvement, instructional strategies, class size, and concerns related to math impact students' interest in mathematics education. Implementing conducive learning environments, enhancing teaching aids, encouraging parental involvement, and providing professional development for teachers are recommended to address these factors and improve students' math comprehension.
Is Cre expression delayed in the dorsal or superior region of the d4-Cre mouse line retina?
4 answers
In the d4-Cre mouse line retina, Cre expression is not delayed in the dorsal or superior region. The d4-Cre mouse line, specifically the Rbp4-Cre mouse, selectively labels various retinal neuronal types involved in encoding absolute light intensity and visual motion, such as wide-field spiking polyaxonal amacrine cells (ACs) and specific types of retinal ganglion cells (RGCs). This mouse model is valuable for targeting and manipulating these cell types for further study and circuit analysis. Additionally, the characterization of Cre expression patterns in the retina is crucial for utilizing transgenic mouse lines effectively, providing a powerful tool for genetic manipulation in the study of visual signal processing within the retina.
How is sustainable development and human nature?
5 answers
Sustainable development is intricately linked to human nature, as evidenced by various research perspectives. The concept of sustainable interdisciplinarity emphasizes the importance of human-nature relations in understanding societal changes and environmental dynamics. Human behavior towards sustainability is shaped by a combination of nature and nurture, showcasing both destructive tendencies and adaptive behaviors throughout history. Efforts to achieve sustainability transformation require rethinking human-nature connections and fostering a partnership approach, moving away from hierarchical relationships towards mutual respect and understanding. The fundamental principle of sustainable development involves improving human quality of life without depleting natural resources, highlighting the need for a new nature-use strategy and the development of innovative energy technologies. Religions, with their unique concepts of human nature, can potentially provide institutional support and influence attitudes towards sustainable policies, complementing traditional economic frameworks.
What are some current research trends and advancements in the field of STEM?
5 answers
Current research trends and advancements in STEM education include a growing interest in quantitative, conceptual, qualitative, mixed, and practice-based research methods, as indicated by studies conducted between 2014 and 2016. Moreover, the field has seen remarkable progress in scanning transmission electron microscopes (STEMs) and electron energy loss spectrometers (EELS) over the last two decades, with modern technologies achieving unprecedented resolutions and capabilities through aberration correction and advanced design features. Additionally, the emergence of human induced pluripotent stem cell (hiPSC) technology has revolutionized schizophrenia research by enabling the study of patient-derived neuronal and glial cell types in vitro, shedding light on molecular and cellular pathways of the disorder and offering new insights into neurogenesis, neuronal maturation, connectivity, synaptic impairment, mitochondrial dysfunction, and miRNA dysregulation.