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How to control your epigenetics?

DNA methylation

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Improved demethylation in ecological epigenetic experiments: Testing a simple and harmless foliar demethylation application

Javier Puy, Hana Dvořáková, Carlos P. Carmona, Carlos P. Carmona, Francesco de Bello, Francesco de Bello, Inga Hiiesalu, Vít Latzel - Show less +7 more

20 Sep 2017-Methods in Ecology and Evolution

26 Citations

This novel method could thus be better suited for experimental studies seeking valuable insights into ecological epigenetics.

Open access•Journal Article•DOI

DNA methylation in childhood asthma: an epigenome-wide meta-analysis

Cheng-Jian Xu, Cilla Söderhäll, Mariona Bustamante, Nour Baïz, Olena Gruzieva, Ulrike Gehring, Dan Mason, Leda Chatzi, Leda Chatzi, Leda Chatzi, Mikel Basterrechea, Sabrina Llop, Maties Torrent, Francesco Forastiere, Maria Pia Fantini, Karin C. Lødrup Carlsen, Karin C. Lødrup Carlsen, Tari Haahtela, Andréanne Morin, Marjan Kerkhof, Simon Kebede Merid, Bianca van Rijkom, Soesma A Jankipersadsing, Marc Jan Bonder, Stephane Ballereau, Stephane Ballereau, Cornelis J. Vermeulen, Raul Aguirre-Gamboa, Johan C. de Jongste, Henriette A. Smit, Ashok Kumar, Ashok Kumar, Ashok Kumar, Göran Pershagen, Stefano Guerra, Judith Garcia-Aymerich, Dario Greco, Lovisa E. Reinius, Rosemary R. C. McEachan, Raf Azad, Vegard Hovland, Petter Mowinckel, Harri Alenius, Harri Alenius, Nanna Fyhrquist, Nanna Fyhrquist, Nathanaël Lemonnier, Nathanaël Lemonnier, Johann Pellet, Charles Auffray, Pieter van der Vlies, Cleo C. van Diemen, Yang Li, Cisca Wijmenga, Mihai G. Netea, Miriam F. Moffatt, William O.C.M. Cookson, Josep M. Antó, Jean Bousquet, Jean Bousquet, Tiina Laatikainen, Tiina Laatikainen, Catherine Laprise, Kai-Håkon Carlsen, Kai-Håkon Carlsen, Davide Gori, Daniela Porta, Carmen Iñiguez, Jose Ramon Bilbao, Manolis Kogevinas, John Wright, Bert Brunekreef, Juha Kere, Juha Kere, Martijn C. Nawijn, Isabella Annesi-Maesano, J Sunyer, Erik Melén, Erik Melén, Erik Melén, Gerard H. Koppelman - Show less +80 more

01 May 2018-The Lancet Respiratory Medicine

147 Citations

Our findings merit further investigations of the role of epigenetics in a clinical context.

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Related Questions

How can epigenetics be used to treat disease?5 answersEpigenetics can be used to treat disease by targeting the molecular hallmarks of epigenomics. This includes the use of compounds that can inhibit chromatin modifying enzymes, such as HDACs, to reverse epigenetic hallmarks and reprogram cells for therapy of various diseases, including cancer, neurological, metabolic, and immunological diseases. In the context of cardiovascular health and disease, epigenetics plays a role in the development of cardiovascular diseases (CVDs) and has paved the way for the development of epi-drugs for the treatment of CVDs. Epigenetics also holds promise as a predictive tool for personalizing medicine in psychiatric disorders, by examining individual patients' epigenetic profiles in conjunction with other indicators. In the field of tumor therapy and autoimmune diseases, epigenetic regulation has been explored as a potential therapeutic strategy, with drugs targeting epigenetic mechanisms being evaluated in clinical trials. Epigenetic changes, such as DNA methylation, histone modification, and miRNA, have been identified in Alzheimer's disease, providing a new avenue for treatment.

How does epigenetics affect the expression of genes?4 answersEpigenetics refers to non-genetic, reversible mechanisms that influence gene expression without altering the DNA sequence. These mechanisms include DNA methylation and histone modifications, which play crucial roles in the development and maintenance of genomic integrity. Epigenetic modifications can change the way DNA is read and affect gene functionality without modifying the underlying DNA sequence. Epigenetic changes can put genes "on" or "off" and impact gene expression, protein production, and functionality. Epigenetic modifications have been found not only on DNA but also on mRNA molecules, collectively known as epitranscriptomics. These modifications, such as N6-methyladenosine (m6A), have been linked to various diseases and cellular processes, including brain development and neurological disorders. Epigenetic changes can be influenced by environmental factors, such as diet and physical activity, and can contribute to the development of genetic, metabolic, and degenerative disorders. Aberrations in epigenetic processes have been associated with diseases like cancer, brain disorders, and metabolic syndromes, leading to advances in epigenetic disease prevention and therapeutics.

How can epigenetics be used to improve health and prevent disease?3 answersEpigenetics has the potential to improve health and prevent disease by providing a better understanding of the molecular basis of complex diseases such as cardiovascular and metabolic disorders. Epigenetic processes, including DNA methylation, can serve as precision medicine biomarkers for these diseases. Additionally, epigenetics research has highlighted the impact of social determinants of health, gut bacterial epigenomics, noncoding RNA, and epitranscriptomics on disease development and progression. By studying epigenetic hallmarks, such as DNA methylation and histone acetylation, it is possible to develop targeted therapies and personalized medicine approaches for cancer, neurological, metabolic, and immunological diseases. Furthermore, the field of epigenetics has paved the way for the development of epi-drugs for the treatment of cardiovascular diseases, such as hypertension, atrial fibrillation, atherosclerosis, and heart failure. Overall, epigenetics has the potential to revolutionize the way we approach diseases, leading to precision medicine, personalized health care, and improved outcomes for individuals worldwide.

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