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These consequences indicated that larger particle size promotes the opportunity for particle mixing and contacting, accordingly increasing the preferential formation of the particle aggregation and deteriorating the reduction performance.
Study with different particle sizes shows that it is possible to achieve an optimum particle size for better handling of such suspension.
The current industry practice of using highly processed, pelleted diets masks the influence of particle size, but some reports suggest that the effects of feed particle size on performance may be maintained even after pelleting.
The particle size has a negative impact on particle growth ratio.
Results of this study demonstrate the advantages and limitations of the individual particle size measurement techniques and should be seen as guidance to select the adequate technique for laser generated aerosol particle size determinations.
The results show that increasing the rate of mixing increases the rate of particle formation while decreasing the variance in the particle size distribution.
Thus, the reduction ratio of particle size before and after devolatilization increases with increasing devolatilization temperature and particle size.
The procedure using narrow feed size fractions can be simplified by using feed material with a broad particle size distribution.
In this “uncoupled limit”, extremely narrow particle size distributions will be attainable.
Our study underlies how measurement of primary particle size highly depends on both powder material and proper particle dispersion.
The first results show that the lengthening of the particle size is attainable.
Our results indicate that various particle size instruments yield significantly (even vastly) different particle size distributions for the same material.
The results of this work provide guidelines for developing strategies to reduce particle size distribution in diesel engines.
Using this technique, the effect of particle size on the particle behavior can be studied with high certainty.
The results show that it is possible to recover the particle size using this approach.
Journal ArticleDOI
Samuel H. Yalkowsky, Sanford Bolton 
82 Citations
It is recommended that particle size specifications for low dose drugs include a requirement for a limit to size distribution.
We suggest that dependence of particle growth mechanisms on particle size needs to be investigated more systematically.

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How to increase the production of exosome?5 answersTo increase the production of exosomes, two main strategies can be employed. The first strategy involves genetic manipulation of the exosome biogenesis and release pathway, such as overexpressing activator genes of exosome biogenesis and downregulating genes involved in exosome recycling pathways. The second strategy involves manipulating the cell culture conditions, such as changing the culture method, adding different components to the medium, or treating cells with specific drugs. By applying these strategies, exosomes can be produced on a large scale to facilitate their practical application in the clinic. Additionally, culturing animal-derived cells in a medium containing TNF-α and interferon-γ has been shown to enhance the productivity of exosomes and reinforce their biological activity. These approaches provide potential ways to increase exosome production for various biomedical applications.
What are the different techniques used to reduce particle size?5 answersSeveral techniques are used to reduce particle size. For solid particulate materials, jet milling, ball milling, and colloid milling are commonly used. Tissue grinder, glass beads, high-speed mixer, polytron, and sonication are some of the techniques used for particle size reduction in discovery with limited API available. A dripping mechanism, vibration wheel, and drive element are used in microencapsulation methods to reduce particle sizes and provide a homogeneous size distribution. Precipitation methods, such as addition of ethanol into an aqueous phase or adding the aqueous phase into the ethanol organic phase, can be used to reduce the particle size of starch. Mechanical techniques like dry-milling, wet-milling, high-pressure homogenization, wet-media milling, piston-gap homogenization, and microfluidization are used to decrease the particle size of solids, including submicron and nano-sized particles.
How to increase the RNA encapsulation rate in particle?4 answersTo increase the RNA encapsulation rate in particles, several methods can be employed. One approach is to mix the mRNA solution and lipid solution at a predetermined temperature greater than ambient temperature. Another method involves providing a first stream comprising an mRNA solution and a second stream comprising a lipid solution, and then mixing the two streams to form mRNA-encapsulated liposomes without the use of a pump. These techniques allow for efficient encapsulation of mRNA in lipid nanoparticles and liposomes, respectively. Additionally, controlling the flow rate of the lipid solution and using a polymeric coating of controlled thickness can also enhance the encapsulation process. By optimizing these parameters, it is possible to achieve a higher rate of RNA encapsulation in particles.
How do you reduce particle size in powder?5 answers
How to increase particle size in API?8 answers

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