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In conclusion, this study was successful in producing liver cirrhosis and offers an ideal experimental model for observing surgical therapeutic efficacy.
CART can be effectively applied as a palliative procedure for refractory ascites of decompensated liver cirrhosis patients.

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What is the relationship between air pollution and kidney disease?
5 answers
Long-term exposure to air pollution, including PM2.5, PM10, NO2, CO, and SO2, has been linked to chronic kidney disease (CKD) and metabolic kidney diseases (MKD), increasing the risk of incident CKD, decline in estimated glomerular filtration rate (eGFR), and progression to kidney failure. Additionally, short-term exposure to air pollutants like PM1, PM2.5, PM10, NO2, and SO2 has been associated with an increased risk of mortality from kidney diseases, indicating a potential environmental risk factor for kidney disease-related deaths. These findings underscore the detrimental impact of air pollution on kidney health, highlighting the importance of further research to elucidate the mechanisms and establish preventive strategies to mitigate the adverse effects of air pollution on kidney function.
Can immunosuppressive drug use be linked to an increased risk of major cardiovascular events for psoriasis?
5 answers
Immunosuppressive drug use in psoriasis treatment has been associated with varying risks of major cardiovascular events (MACE). Studies have shown contrasting results regarding the risk of MACE with different immunosuppressive therapies. Vegas et al. found a significantly greater risk of MACE with IL-12/23 and IL-17 inhibitors compared to TNF inhibitors. Dotan et al. reported that bDMARDs did not significantly increase MACE risk in psoriasis patients, unlike cDMARDs. Li and Liu emphasized the need for further research to validate the cardioprotective effects of TNFi therapy in psoriasis patients. Rungapiromnan et al. observed no significant differences in MACE risk between different biologic therapies and methotrexate in psoriasis patients. Persson et al. found low MACE incidence rates across various systemic treatments for psoriatic arthritis, with apremilast not showing increased cardiovascular risk.
Are people of african descent more likely to have elevated periostin?
5 answers
Individuals of African descent may not necessarily have higher levels of periostin based on the available research data. While the studies do not specifically address ethnicity in relation to periostin levels, they provide insights into various conditions where periostin is implicated. Research indicates that periostin levels are elevated in conditions like Type 2 diabetes mellitus (T2DM) without and with COVID-19, chronic rhinosinusitis with nasal polyps (CRSwNP), and among older adults associated with declines in physical and cognitive capacities. Additionally, periostin has been studied in kidney transplant recipients, showing lower levels in these patients compared to healthy volunteers. Therefore, while ethnicity is not directly addressed, the available data suggests that periostin levels are influenced by various health conditions rather than ethnicity.
What is the global market of energy drinks?
5 answers
The global market of energy drinks has experienced significant growth, with estimates projecting it to reach $61 billion by 2021. In the UK alone, sales of energy drinks increased by 155% between 2006 and 2014, reaching 600 million liters consumed annually. The market for energy drinks is expanding at an annual rate of 3.5% globally, contrasting the decline in soda sales. In the United States, the energy drink market was valued at $5.4 billion in 2006, indicating its substantial presence in the non-alcoholic beverage industry. This growth is fueled by the popularity of energy drinks among various demographics, including young people, students, athletes, and office workers.
Can non-compliance in taking medication cause withdrawal syndrome in epilepsy?
5 answers
Non-compliance in taking medication for epilepsy can indeed lead to withdrawal symptoms. Studies have shown that non-adherence to antiepileptic drugs (AEDs) can result in breakthrough seizures, emergency department visits, and increased mortality rates. Furthermore, patients who stop taking their medication once symptoms subside or due to forgetfulness are at risk of experiencing withdrawal symptoms and increased seizure activity. It has been observed that patients who are non-compliant with their medication regimen are more likely to have poor seizure control and experience convulsive seizures, highlighting the importance of adherence to AED therapy in preventing withdrawal symptoms and maintaining seizure management. Therefore, ensuring medication compliance is crucial in preventing withdrawal syndrome and its associated risks in epilepsy patients.
What are effects of genotoxic compounds on the development of the breastfed infant?
5 answers
Genotoxic compounds can have significant impacts on breastfed infants' development. Exposure to genotoxic substances through breast milk can lead to DNA damage in infants. Studies on human milk oligosaccharides, like 3‐fucosyllactose, have shown that structurally identical compounds produced for infant formula are safe, with no genotoxic effects observed. Environmental genotoxicants, such as bisphenols and mycotoxins, pose risks to human health by inducing mutations that can result in cancer and other diseases. Organochlorine pesticides (OCPs) are bioaccumulative substances that can pass into breast milk, affecting infants' central nervous system, immune system, and overall health. While postnatal exposure to neurotoxic persistent organic pollutants (POPs) through breastfeeding can increase infants' blood levels of these compounds, the detrimental effects on neuropsychological development are primarily attributed to prenatal exposure.
How does mirror therapy relieve phantom limb pain?
4 answers
Mirror therapy has been shown to effectively relieve phantom limb pain (PLP) by providing visual feedback to the brain. By using a mirror to reflect the intact limb, patients can visually perceive movement in the missing limb, leading to a reduction in pain intensity and duration. This visual illusion helps rewire the brain's perception of the missing limb, alleviating the sensation of pain. Additionally, mirror therapy can be enhanced by combining it with progressive muscle relaxation techniques, further improving its efficacy in managing PLP. The combination of mirror therapy with other interventions like magnetic stimulation or virtual reality systems has shown promising results in reducing PLP and improving function in patients with lower extremity amputations.
Does metformin cause mitochondrial toxicity?
5 answers
Metformin's impact on mitochondria is complex and context-dependent. While some studies suggest potential toxicity in older rats, others highlight its protective role in mitigating mitochondrial dysfunction induced by oxidative stress. Additionally, metformin has been shown to increase mitochondrial reactive oxygen species (ROS) production and disturb mitochondrial activity in cancer cells. However, in the context of anthracycline-induced cardiotoxicity, metformin demonstrates a protective effect by maintaining mitochondrial homeostasis and mitigating endothelial impairment. Overall, the evidence is mixed, with some studies indicating potential benefits or neutral effects on mitochondrial function, while others suggest possible adverse outcomes, emphasizing the need for further research to fully understand metformin's impact on mitochondria.
How to treat behcet's disease?
5 answers
Treatment of Behçet's disease involves a multidisciplinary approach tailored to the individual's symptoms and disease course. Initial acute phases are managed with corticosteroids, but their long-term use is limited due to serious adverse effects. Conventional disease-modifying anti-rheumatic drugs like azathioprine and cyclosporine are commonly used. Biologic therapies, particularly tumor necrosis factor-alpha (TNF-α) antagonists such as adalimumab and infliximab, have shown efficacy in severe cases, especially with ocular and gastrointestinal involvement. Additionally, Janus kinase inhibitors like tofacitinib have shown promise in refractory cases. Treatment should focus on controlling inflammation, preventing relapses, and managing complications to improve outcomes and reduce morbidity and mortality. A personalized treatment plan should be devised based on the organs involved and disease severity, with close monitoring and follow-up.
Cannabinoids in Acne Management: Recent Scientific Insights and Therapeutic Innovations?
5 answers
Recent scientific insights highlight the potential of cannabinoids in acne management. The endocannabinoid system's connection to skin health and wound healing suggests cannabinoids could offer therapeutic benefits for acne treatment. Cannabinoids, such as CBD, have shown immunosuppressive and anti-inflammatory properties, which are crucial in addressing the underlying pathways contributing to acne development. Additionally, advancements in cannabinoid delivery methods, including topical and transdermal applications, enhance bioavailability and minimize psychotropic effects, making them promising for acne management. While further controlled clinical studies are needed to establish cannabinoids' definitive role in acne pathophysiology, the rising interest in cannabinoid research and their therapeutic potential indicates a promising future for innovative acne treatments utilizing cannabinoids.
What is the current stand on oral Microbiome and Covid19?
5 answers
Current research indicates a significant association between COVID-19 and alterations in the oral microbiome. Studies have shown that COVID-19 patients exhibit oral microbial dysbiosis with reduced diversity, particularly with changes in specific bacterial members like Neisseria and Streptococcus. Furthermore, recovered COVID-19 patients have shown normalization in oral bacterial and fungal diversity post-infection, with shifts towards beneficial organisms and away from opportunistic pathogens. Interestingly, the salivary microbiota has been linked to the humoral response to SARS-CoV-2 vaccination in immunocompromised individuals, suggesting a potential role of oral pathobionts like Neisseria and Prevotella in priming vaccine-induced immunity. Additionally, the oral microbiome diversity has been negatively correlated with COVID-19 severity, indicating its potential as a predictive marker for disease status and severity.