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How to sensitize serotonin receptors? 

Serotonergic
5-HT receptor
Receptor
Central nervous system
Serotonin

Answers from top 10 papers

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Papers (10)Insight
Journal Article•DOI
Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs
B. P. Richardson, G. Engel, P. Donatsch, P. A. Stadler 
11 Jul 1985-Nature
845 Citations
We describe a new class of drugs that selectively block serotonin M-receptors on peripheral neurones.
Open access•Journal Article•DOI
Receptors and Other Signaling Proteins Required for Serotonin Control of Locomotion in Caenorhabditis elegans
Güliz Gürel, Megan A Gustafson, Judy S Pepper, H. Robert Horvitz, Michael R. Koelle 
01 Dec 2012-Genetics
79 Citations
Our results show that serotonin functions as an extrasynaptic signal that independently activates multiple receptors at a distance from its release sites and identify at least six additional proteins that appear to act with serotonin receptors to mediate serotonin response.
Book Chapter•DOI
Serotonin Receptors in Vascular Smooth Muscle
Marlene L. Cohen
01 Jan 1988
14 Citations
Based on this multiplicity of effects and target tissues, it is not surprising that different types of receptors can selectively mediate effects of serotonin.
Journal Article•DOI
Methiothepin-sensitive serotonin receptors are involved in the postsynaptic mechanism of sensitization of the defensive response in the common snail.
M. S. Abramova, V. L. Nistratova, A. A. Moskvitin, Arkady S. Pivovarov 
01 Jul 2006-Neuroscience and Behavioral Physiology
16 Citations
It is suggested that methiothepin-sensitive serotonin receptors are involved in the postsynaptic mechanism of behavioral sensitization.
Journal Article•DOI
Multiple mechanisms of serotonin 5-HT2 receptor desensitization.
Shafiqur Rahman, Richard S. Neuman 
20 Jul 1993-European Journal of Pharmacology
42 Citations
We conclude that serotonin 5-HT2 receptors both induce and undergo several forms of desensitization.
Open access•Journal Article
Serotonin receptor specificity in anxiety disorders.
Irwin Lucki
01 Jan 1996-The Journal of Clinical Psychiatry
59 Citations
Selective compounds for particular subtypes of serotonin receptors may yield selective pharmacologic effects.
Open access•Journal Article•DOI
Serotonin 1A and Serotonin 4 Receptors Essential Mediators of the Neurogenic and Behavioral Actions of Antidepressants
Benjamin Adam Samuels, Indira Mendez-David, Charlène Faye, Sylvain André David, Kerri A. Pierz, Alain M. Gardier, René Hen, Denis J. David 
01 Feb 2016-The Neuroscientist
80 Citations
Ultimately, we propose that novel antidepressant drugs that selectively target these serotonin receptors could be developed to yield improvements over current treatments for major depressive disorders.
Journal Article•DOI
Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortex.
Françoise Biver, David Wikler, Françoise Lotstra, Philippe Damhaut, Serge Goldman, Julien Mendlewicz 
01 Nov 1997-British Journal of Psychiatry
210 Citations
BACKGROUND Serotonin receptors may play an important role in the pathophysiology of affective disorders.
Book Chapter•DOI
Influence of Serotonin on the Blood–Brain and the Blood–Spinal Cord Barriers
Hari Shanker Sharma
01 Jan 2004
18 Citations
This effect of serotonin is mediated via serotonergic receptors.
Open access•Journal Article•DOI
Photophysics of a neurotransmitter: ionization and spectroscopic properties of serotonin
Amitabha Chattopadhyay, R. Rukmini, Sushmita Mukherjee 
01 Oct 1996-Biophysical Journal
95 Citations
In view of the multiple roles played by the serotonergic systems in the central and peripheral nervous systems, these results are relevant to future studies of serotonin and its binding to its receptors.

Related Questions

How long do serotonin receptors take to heal?5 answersSerotonin receptors can exhibit varying recovery times based on the specific conditions and age. Studies have shown that the recovery of 5-HT2 receptors in the frontal cortex of rats can differ between mature and senescent individuals, with senescent rats displaying a slower recovery process. Additionally, the healing process of serotonin neurons in rats treated with MDMA indicated a significant reduction in neuronal markers initially, followed by a gradual recovery over time, with some animals showing enduring deficits even after a year. Furthermore, the effects of S(2)-receptor blockers on collagen-induced injuries in tendons demonstrated a significant impact on collagen turnover and scar tissue organization during the early stages of healing. These findings collectively suggest that the healing duration of serotonin receptors can vary depending on the specific circumstances and age-related factors.
What are the different types of drugs that act on serotonin receptors?4 answersThere are several types of drugs that act on serotonin receptors. Conventional serotonin-enhancing antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), increase synaptic neurotransmission of serotonin through stimulation and blockade of various subtypes of 5-HT receptors. Serotoninergic hallucinogens, such as lysergic acid diethylamide (LSD), dimethyltryptamine (DMT), and psilocybin, agonistically act on 5-HT2A receptors, leading to increased glutamatergic transmission and neuroplasticity. Additionally, there are selective ligands and drugs that target specific 5-HT receptor subtypes, such as lorcaserin and pimavanserin, which target the 5-HT2C and 5-HT2A receptors, respectively, and provide new treatments for obesity and Parkinson's disease psychosis. Serotonin receptor ligands, including aripiprazole, ziprasidone, risperidone, olanzapine, mianserin, and quetiapine, are used for the treatment of central nervous system-related disorders. These drugs and ligands interact with different serotonin receptor subtypes to modulate serotonin neurotransmission and have therapeutic effects on various neuropsychiatric disorders.
Describe drugs that act on serotonin receptors including examples ?5 answersDrugs that act on serotonin receptors include atypical antipsychotic drugs (APDs) such as clozapine, aripiprazole, asenapine, iloperidone, lurasidone, olanzapine, quetiapine, risperidone, and ziprasidone. These drugs produce extensive blockade of serotonin (5-HT)(2A) receptors and may also stimulate 5-HT(1A) receptors. Some atypical APDs are also effective 5-HT(2C) receptor inverse agonists or neutral antagonists, 5-HT(6) or 5-HT(7) receptor antagonists. In addition to atypical APDs, there are other drugs that modulate serotonin receptors. For example, there are modulators of serotonin receptors that are being investigated for the treatment of various diseases and conditions such as metabolic diseases, central nervous system diseases, cephalic pain, migraine, and gastrointestinal disorders. Serotonin is one of the most important neurotransmitters in the central nervous system and is associated with the pathophysiology of many diseases including anxiety, schizophrenia, depression, and eating disorders.
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