How would an off center neuron's firing rate change when a light was turned on turned off and then turned on again?
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| There also appeared to be an indirect GABAergic influence on a subclass of off-center ganglion cell. | |
| Because extra spikes often first appear during a decline in firing rate, turning on and then off, an additional current may sometimes activate the extra spike mode, thus doubling the resting firing rate in a metastable manner. | |
| There is little doubt that each subfield is generated by excitatory input from geniculate neurons of the appropriate center type: ON subfields by ON-center cells, and OFF subfields by OFF-center cells. | |
47 Citations | This served to amplify the release of a neurotransmitter when a bright light is turned off, and thus selectively amplify the off response to the light signal. |
9 Citations | The results indicate that the firing of ON-spikes was influenced by the recent firing of OFF-spikes, and vice versa. |
| Possibly influenced by cholinergic On and glutamatergic Off cells, whose change in discharge precedes theirs, the GABAergic Off cells could oppose neighboring neurons such as noradrenergic cells, which discharge during waking and cease firing during sleep. | |
25 Citations | For an individual neuron, we suggest that firing rate is a measure of the probability that the target is at the center of the neuron's response field. |
36 Citations | The uncoupling effect of flickering light was also blocked in the presence of 2-amino-4-phosphonobutyrate (APB), which prevents light responses of on-center but not off-center bipolar cells, suggesting that flickering light increases dopamine release via the on-pathway. |
| Surprisingly, the optimal ON–OFF system transmits the same information as the optimal ON–ON system, if one constrains the maximal firing rate of the neurons. | |
| Recent results on coordinated reset and periodically forced oscillators suggest that forming distinct clusters of neurons may prove to be more effective than achieving complete desynchronization by promoting plasticity effects that might persist after stimulation is turned off. | |
| In addition they suggest a model of the neuronal connections which subserve on-center, off-center, and on-off ganglion cells. | |
87 Citations | Thus, if a high-frequency burst represents the ‘on’ state of a neuron, we failed to demonstrate persistent states in which a group of neurons is turned ‘on’ together. |
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