Is cell lysis and apoptosis the same?
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| There is often a continuum of apoptosis and necrosis in response to high and low doses of the same stimulus and features of both apoptosis and necrosis may coexist in the same cell. | |
160 Citations | We conclude that either necrosis or apoptosis can occur in the same cell type, depending on the trigger, and that, although both pathways perhaps may share some cellular components, signal transduction is different for the two types of cell death. |
Open access•Journal Article 22 Citations | These results indicate that although other modes of cell death exist, apoptosis is the most efficient and requires lower drug concentrations and fewer numbers of non-repaired dsb to give the same killing effect. |
| Moreover, several evidence point to severer apoptosis-like cell death in 0.7 mM treatments, involving fastest and severest cell lysis, smallest cell size and wrinkled surface and lowest membrane potential. | |
9 Citations | Although cell death can occur by apoptosis or necrosis, apoptosis is an energy-requiring process that is genetically regulated.1 Cell death by necrosis involves depletion of cellular ATP stores, cell swelling, and disruption of the cell membrane. |
20 Citations | Our results indicate that the variation in apoptosis between drugs that act at the same phase of the cell cycle is negligible. |
30 Citations | The overall results demonstrated that apoptosis, which is a carefully regulated process of cell death, may proceed through mechanisms varying according to cell type or apoptosis inducer. |
44 Citations | Thus caspase inhibitors prevent the hallmark phenotype of apoptosis without measurably affecting target cell death as evidenced by lysis. |
85 Citations | We propose a model of pyroptosis in which cell death can occur independently of cell lysis. |
76 Citations | Thus, depending on the method used, the extent of apoptosis determined in the same cell population may vary. |
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