scispace - formally typeset
Search or ask a question

Answers from top 4 papers

More filters
Papers (4)Insight
The effects of breakfast cereal consumption and digestive problems were independent, and further research is required to identify the mechanisms underlying these effects
These findings highlight a potential strategy to prevent cereal toxicity in celiac disease.
Our results indicated that rice cereal is well absorbed by young infants with acute diarrhea and that it is an adequate nutrient supplement for this patient population.
From these studies, the pathogenesis of nutritional cirrhosis is suggested to be as follows.

See what other people are reading

What are the most common diagnostic tests used to detect chronic wasting disease in animals?
5 answers
What are healthcare professionals perceptions of management strategies for alpha-1 antitrypsin deficiency associated liver disease?
5 answers
How to treat AKI in cirrhosis?
5 answers
How to treat AKI in cirrhosis?
5 answers
Have any studies used ChatGPT to code/rate variables instead of coders into categories?
5 answers
What are the genetic mutations associated with hereditary haemochromatosis?
4 answers
Hereditary Hemochromatosis (HH) is primarily associated with mutations in the HFE gene, particularly the p.Cys282Tyr mutation. Other mutations in genes involved in iron regulation, such as haemojuvelin, hepcidin, transferrin receptor 2, and ferroportin 1, can also lead to iron overload. In individuals of Irish heritage, HFE gene mutations like C282Y homozygous, C282Y/H63D compound heterozygous, and H63D homozygous are common, contributing to HH risk. Despite the potential link between HFE gene mutations and cardiovascular diseases, a study in eastern Slavonia found no significant association between HFE gene mutations (C282Y, H63D, S65C) and myocardial infarction. Understanding these genetic mutations is crucial for diagnosing HH, guiding treatment decisions, and genetic counseling.
What is the pharmacokinetics of pravastatin 10 mg in humans?
5 answers
Pravastatin, a statin used for hypercholesterolemia, exhibits unique pharmacokinetic characteristics in humans. It is primarily eliminated via hepatobiliary excretion mediated by OATP1B1 and MRP2 transporters. Pravastatin's hepatic uptake is facilitated by OATP1B1, with SLCO1B1 polymorphisms affecting its plasma concentrations. The drug undergoes minimal cytochrome P450 metabolism, further emphasizing the role of transporters in its disposition. Pravastatin's low oral bioavailability is due to incomplete absorption and significant first-pass effect, with active transport mechanisms involved in its uptake by the liver. The drug is mainly cleared through hepatic and renal routes, with tubular secretion playing a crucial role in renal excretion. Overall, pravastatin's pharmacokinetics are influenced by transporter activities, genetic polymorphisms, and unique elimination pathways, highlighting its distinct profile among statins.
Why guargum and chitosan are used as blend for making thin films?
4 answers
Guar gum and chitosan are utilized as a blend for making thin films due to their advantageous properties. Guar gum, when crosslinked with chitosan, results in a composite film with superior characteristics such as high mechanical strength, water stability, and resistance to harsh environmental conditions. Chitosan, a biodegradable and biocompatible material, can be combined with other polymers like Poly Lactic Acid (PLA) to enhance film properties, although it is generally insoluble in water. Chitosan coatings can be prepared to be smooth and stable, suitable for various biomedical applications, by grafting them onto surfaces using optimized methods, making them insoluble in acidic aqueous conditions. Additionally, chitosan is a sustainable biopolymer that can form electrical double layers and be integrated as a dielectric in thin films.
What is the global epidemiology of adenovirus according to the World Health Organization?
5 answers
The global epidemiology of adenovirus infections involves various manifestations and impacts. Adenoviruses are known to cause respiratory, gastrointestinal, and ocular infections, with severe cases leading to high fatality rates, especially in immunocompromised individuals. Different serotypes of adenovirus exhibit varying tissue tropisms and clinical outcomes, with transmission patterns influenced by factors like geographical location and time, leading to the circulation of different serotypes in different regions. Adenovirus outbreaks causing keratoconjunctivitis, pharyngoconjunctival fever, and acute hemorrhagic conjunctivitis have been reported worldwide, with distinct circulating patterns and serotypes associated with each type of conjunctivitis. Additionally, adenovirus infections have been implicated in cases of acute hepatitis, including outbreaks with unknown etiology, emphasizing the need for further investigation into the relationship between adenovirus and other pathogens like SARS-CoV-2.
What is celiac disease, in children?
4 answers
Celiac disease in children is a chronic immune disorder triggered by gluten consumption in genetically predisposed individuals. Diagnosis in children relies on specific antibodies in the blood, such as anti-tissue transglutaminase (tTG) and genetic testing for HLA DQ2 or DQ8 genes. Pediatric potential celiac disease (PCD) is characterized by positive celiac serology without villous atrophy, with less than 15% of cases progressing to full celiac disease during short-term follow-up. In rare instances, celiac disease can manifest as a celiac crisis, a severe and life-threatening condition that requires prompt identification and management to prevent fatal complications. Environmental factors like gut microbiota composition play a role in celiac disease pathogenesis, with factors such as cesarean birth, formula feeding, and intestinal infections influencing disease risk in genetically predisposed individuals. Regular serological and histological follow-up is crucial for children with potential celiac disease to monitor disease progression.
Is there a study that analyze the impact of gender on liver injury among COVID patients?
5 answers
Gender differences in liver injury among COVID-19 patients have been studied. Research conducted in Nepal and Iraq revealed significant associations between gender and liver injury. In Nepal, males were found to have 1.78 times higher odds of developing liver injury compared to females, with CRP levels over 10 indicating a higher likelihood of liver injury. Similarly, in Iraq, males showed a higher incidence of liver dysfunction compared to females, with significant differences in serum AST and ALT levels between the sexes. These findings underscore the importance of considering gender disparities in liver injury outcomes among COVID-19 patients, highlighting the need for tailored approaches to patient care based on gender differences.