Is Cody Hackman related to Gene Hackman?
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72 Citations | Although CodY is a strong repressor of the agr locus, CodY bound only weakly to the agrBDCA-RNAIII promoter region, suggesting that direct regulation by CodY is unlikely to be the principal mechanism by which CodY regulates agr and RNAIII expression. |
58 Citations | Under these conditions, CodY loses the ability to repress genes (e. g., metabolic genes) and functions as a direct activator of the master virulence regulator gene, prfA. |
34 Citations | Of the 389 DNA binding sites that were copurified with CodY, 132 sites were in or near the regulatory regions governing the expression of 197 CodY-controlled genes, indicating that CodY controls many other genes indirectly. |
175 Citations | CodY is likely to play an important role in regulating overall cellular physiology as well. |
26 Citations | GTP enhanced the binding affinity of CodY to the botA promoter, suggesting that CodY-dependent neurotoxin regulation is associated with nutritional status. |
58 Citations | This observation raised the possibility that CodY possesses multiple functions that allow it to coordinate gene expression across a wide spectrum of metabolic growth conditions, and thus better adapt bacteria to the mammalian niche. |
57 Citations | CodY acts by directly, and indirectly (via Agr), repressing toxin production during times of plentiful nutrition. |
58 Citations | We demonstrate here that CodY is indeed active (i. e., binds DNA) under both conditions, serving as a repressor and activator of different genes. |
53 Citations | In vitro, CodY represses the transcription of virulence genes, but it is not known if CodY also represses virulence in vivo. |
22 Citations | Thus, in B. subtilis, CodY can now be seen to regulate the entire protein utilization pathway. |
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