Search or ask a question

Is Covaxin safe for epileptic?

Electrophysiology

Epileptic seizure

Centre for Reviews and Dissemination

Answers from top 3 papers

PDF

Open Access

More filters

Papers (3)	Insight
Journal Article•DOI Thyroid hormone concentrations in epileptic patients. J. G. Larkin, G. J. A. Macphee, G H Beastall, MartinJ. Brodie - Show less +3 more 01 Jan 1989-European Journal of Clinical Pharmacology 36 Citations	These data support the influence of enzyme induction as a likely mechanism for reduced thyroxine concentrations in treated epileptic patients.
Journal Article•DOI Lacosamide as adjunctive therapy for partial-onset epileptic seizures: a review of the clinical and economic literature. Steven Simoens 15 Jun 2011-Current Medical Research and Opinion 12 Citations	These studies showed that standard anti-epileptic drug therapy plus lacosamide is likely to constitute a cost-effective alternative.
Journal Article•DOI Chronic epileptic foci in vitro in hippocampal slices from rats with the tetanus toxin epileptic syndrome. John G. R. Jefferys 01 Aug 1989-Journal of Neurophysiology 59 Citations	The tetanus toxin experimental epileptic syndrome differs from chronic models described previously in retaining in the hippocampal slice in vitro much of the spontaneous epileptic activity seen in vivo in the freely moving chronically epileptic rat.

My columns

Related Questions

Is seizure prophylaxis for intracranial bleed helpful?3 answersSeizure prophylaxis for intracranial bleed is not supported by the current evidence. Multiple studies have shown that antiepileptic drug (AED) prophylaxis does not reduce the risk of seizures in patients with spontaneous intracerebral hemorrhage (ICH). Furthermore, AED prophylaxis has been associated with poor functional outcomes in these patients. The impact of seizures on prognosis after intracerebral hemorrhage is still debated, and it remains unclear if treating or preventing seizures improves clinical outcomes. Decision analysis models suggest that short-term (7-day) prophylaxis may be more beneficial than longer-term therapy after spontaneous intracerebral hemorrhage. However, further randomized controlled trials are needed to determine the efficacy of seizure prophylaxis in high-risk patients and with different types of antiepileptic drugs. In conclusion, the current evidence does not support routine seizure prophylaxis in patients with intracranial bleed.

Can Covaxin cause low platelet count?5 answers

Is Allegra safe for epilepsy?4 answers

Is Covaxin safe for autoimmune disease?8 answers

Is Covaxin under clinical trial?4 answers

Is it OK to take Valtrex with Covid vaccine?4 answers

See what other people are reading

How is blinking related to other eye activities?

Blinking is intricately linked to various eye activities and can serve different purposes across different contexts. Research has shown that blinking rates can be influenced by external stimuli, such as music listening, with increased blink rates observed during certain activities like music listening. Additionally, studies on primates have revealed a correlation between social factors like group size and blink rates, suggesting that spontaneous eye blinks may play a role in social communication and adaptation to complex social living. Furthermore, blinking patterns can also be indicative of underlying neurological conditions, as seen in cases where abnormal blinking was the first clinical manifestation of epilepsy, highlighting the importance of differentiating between voluntary actions, tics, and neurological disorders in clinical settings. These findings collectively underscore the multifaceted nature of blinking and its relevance to subjective states, social interactions, and neurological health.Why are cortical children vulnerable?

Cortical children are vulnerable due to various factors such as genetic influences, brain anatomy disruptions, and differential vulnerability to mechanisms like apoptosis, oxidative stress, and autophagy. Additionally, cortical visual dysfunction in children, although less studied than in adults, presents unique challenges due to the evolving visual system and difficulties in communication. Furthermore, malformations of cerebral cortex development (MCCD) in children can lead to epileptic seizures, psychomotor delays, and drug-resistant epilepsy, necessitating neurosurgical interventions for improved management and quality of life. Understanding the biological underpinnings of vulnerability in cortical children is crucial for developing targeted interventions and support strategies.Most eefctive tretament for eplilepsy in woen under 8 years of age?

Epilepsy surgery has emerged as an effective treatment for children with pharmacoresistant epilepsy, including those under 8 years old. Surgical interventions like hemispherotomy have shown excellent seizure control outcomes in very young children, with a majority achieving seizure freedom postoperatively. The selection of suitable candidates for surgery is crucial, with a focus on early intervention within two years of epilepsy onset and achieving complete resection of the epileptogenic zone. Surgical techniques such as disconnective procedures have been preferred over extensive resections due to their equivalent seizure outcomes and reduced complication rates. Overall, epilepsy surgery, particularly hemispherotomy, has been successful in providing seizure control and improving the quality of life in children under 8 years old with pharmacoresistant epilepsy.What is the role of cardiac muscles in the respiratory system of Achatina fulica?

The cardiac muscles in the respiratory system of Achatina fulica play a crucial role in regulating the heartbeat. Research has shown that the two largest neurons, d-VLN and d-RPLN, located on the dorsal surface of the visceral and right parietal ganglia of the giant African snail, are involved in controlling the heartbeat. These neurons generate discrete biphasic inhibitory-excitatory junction potentials (I-EJPs) in the heart and various muscles of the visceral sac, indicating their influence on cardiac function. The duration of the hyperpolarizing phase of these potentials was found to be significantly shorter compared to other inhibitory potentials, showcasing the unique regulatory mechanisms of the cardiac muscles in Achatina fulica.Is there a dose response of diazepam for seizure disorder?

A dose-response relationship of diazepam for seizure disorders has been explored in various studies. A population pharmacokinetic model of intravenous diazepam in children with status epilepticus demonstrated that higher doses of diazepam led to a more rapid achievement of the therapeutic range. Additionally, a study on a novel intranasal formulation of diazepam showed dose-dependent exposure patterns, with higher doses resulting in increased peak concentrations. Furthermore, in patients with refractory complex partial seizures, a dose-response analysis of vigabatrin indicated that increasing dosages led to a reduction in daily seizure rates. These findings collectively suggest that there is indeed a dose-response relationship for diazepam in the management of seizure disorders.What is the definition of epileptic seizure prediction?

Epileptic seizure prediction involves utilizing machine learning algorithms and EEG data to forecast the occurrence of seizures in epilepsy patients. Various studies propose innovative approaches to enhance prediction accuracy and reduce false alarm rates. These methods typically involve analyzing EEG signals, extracting patient-specific features, and classifying between preictal (before a seizure) and interictal (non-seizure) states. By employing techniques like wavelet transforms, convolutional neural networks, and fusion features, researchers aim to develop personalized models capable of accurately identifying seizure phases. Automated seizure prediction systems offer significant benefits by providing timely alerts to patients, potentially preventing dangerous situations and improving overall quality of life.What is the JAK-STAT pathway?

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is a crucial signaling mechanism involved in various biological processes, including cell growth, differentiation, immune regulation, and disease progression. This evolutionarily conserved pathway allows cells to communicate with their external environment by transducing signals from cytokines, interferons, and growth factors. Dysregulation of the JAK-STAT pathway is strongly linked to immune activation, inflammation, and cancer development. The pathway is also significant in insect immunity and physiological regulation processes. Moreover, it plays a role in diseases like epilepsy, where it presents a potential target for treatment. The complexity of the JAK-STAT pathway, influenced by factors like cytokine diversity and regulatory proteins, underscores its importance in both basic research and clinical applications.Can in-silico studies accurately predict the onset of paroxysmal conditions in patients?

In-silico studies have shown promise in predicting the onset of paroxysmal conditions in patients. Research suggests that machine learning models utilizing heart rate variability parameters can potentially predict paroxysmal atrial fibrillation onset. Additionally, individualized optimization strategies based on molecular sub-regional stratification have significantly improved the predictive performance of in silico algorithms for epilepsy-related gene variants. Moreover, computational models utilizing interictal electrographic data have successfully localized seizure foci and simulated surgical interventions, demonstrating a potential to predict and reduce the likelihood of seizures in epilepsy patients. Furthermore, in-silico workflows have been proposed to identify sensitivities of genes to chemical exposures, predicting conditions sensitive to cumulative chemical exposures, including various cancers and metabolic disorders.Can the Lorenz plot method be performed using fingertip pulse wave?

The Lorenz plot method can indeed be adapted for use with fingertip pulse waves. While traditionally applied in heart rate variability analysis, recent advancements have explored automatic detection methods based on Lorenz plot shapes, enhancing accuracy and efficiency. Moreover, modifications to the Lorenz plot have enabled the detection of focal epileptic seizures through short-term HRV analysis, showcasing its adaptability to different physiological phenomena. Additionally, the method has been successfully utilized in vivo algae excitation fluorescence analysis, demonstrating its versatility beyond cardiac applications. Furthermore, a novel technique utilizing Lorenz plots with RR intervals from ECG recordings has shown promise in estimating sleep stages throughout the night, indicating its potential for diverse physiological monitoring applications.Is absence epilepsy benign ?

Absence epilepsy, although traditionally considered benign due to its non-convulsive nature and high remittance rate, can present challenges. Studies show that a significant portion of children with absence seizures are pharmaco-resistant and experience severe neuropsychiatric comorbidities, including attention deficits and cognitive impairments. Additionally, the coexistence of benign epilepsy with centro-temporal spikes (BECTS) and childhood absence epilepsy (CAE) can complicate the clinical picture, with some patients showing atypical evolution of BECTS leading to CAE. While most patients with childhood absence epilepsy may become seizure-free, a subset may have resistant forms, emphasizing the need for careful management and monitoring to address potential cognitive and neuropsychological challenges. Overall, the characterization of absence epilepsy as entirely benign may need to be reconsidered in light of these complexities and individual variations in presentation and treatment response.What are the current treatment options for individuals with syngap1 deficiency?

Current treatment options for individuals with SYNGAP1 deficiency include transdermal administration of cannabidiol (CBD) to alleviate SYNGAP1 symptoms. Additionally, studies have shown that restoring depressed intrinsic membrane excitability (IME) in SYNGAP1 deficient neurons through genetic targeting of hyper-functional potassium currents can promote dendritic morphogenesis in cortical pyramidal neurons, stimulating the assembly of excitatory circuit motifs. Moreover, research using xenotransplantation of human cortical neurons into mouse cortex has demonstrated that SYNGAP1 haploinsufficiency leads to accelerated morphological and functional synaptic development, disrupting neuronal neoteny and impacting sensory responsiveness, highlighting the importance of understanding these mechanisms for diagnosis and treatment of SYNGAP1-related intellectual disability and autism spectrum disorder.