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Is epilepsy and Mirgi same?

Tumor necrosis factor alpha

Epileptogenesis

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Open access•Journal Article•DOI MicroRNAs as Immune Regulators of Inflammation in Children with Epilepsy. Haiam Abdel Raouf, Naglaa Kholoussi, Eman Eissa, Hala G. El Nady, Dalia Bayoumi Fayed, Rania Fawzy Mahmoud Abdelkawy - Show less +5 more 10 Aug 2020-International Journal of Molecular and Cellular Medicine 4 Citations	MiR-125a and miR-181a could be involved in the pathogenesis of epilepsy and could serve as diagnostic biomarkers for pediatric patients with epilepsy.
Open access•Journal Article•DOI LncRNA NEAT1 affects inflammatory response by targeting miR-129-5p and regulating Notch signaling pathway in epilepsy Yi Wan, Zhi-Quan Yang - Show less +1 more 17 Jan 2020-Cell Cycle 44 Citations	The present study verified that lncRNA NEAT1 affected inflammatory response of epilepsy by suppressing miR-129-5p and further regulating Notch signaling pathway in IL-1β-induced epilepsy cell model.
Open access•Journal Article•DOI Two novel epilepsy-linked mutations leading to a loss of function of LGI1. Elodie Chabrol, Cyprian Popescu, Isabelle Gourfinkel-An, Oriane Trouillard, Christel Depienne, Kristen Senechal, Michel Baulac, Eric LeGuern, Stéphanie Baulac - Show less +8 more 01 Feb 2007-JAMA Neurology 49 Citations	Our data indicate that LGI1 is a secreted protein and suggest that LGI1-related epilepsy results from a loss of function.
Open access•Journal Article•DOI microRNA-182 Negatively Influences the Neuroprotective Effect of Apelin Against Neuronal Injury in Epilepsy. Han Dong, Bin Dong, Na Zhang, Songyan Liu, Huiying Zhao - Show less +4 more 30 Jan 2020-Neuropsychiatric Disease and Treatment 12 Citations	Hence, miR-182/APLN may be potential targets for epilepsy control and treatment.

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Give an compering between old drugs of epilepsy and new one?5 answersNewer antiseizure medications (ASMs) offer advantages over traditional drugs in epilepsy treatment. While the antiseizure effects of new ASMs are not superior to traditional ones, they have improved tolerability, fewer drug interactions, and lower teratogenicity, enhancing adherence and enabling combination therapy for drug-resistant epilepsy. Studies show that second- and third-generation ASMs have similar efficacy to carbamazepine for focal epilepsy but may not be as effective as valproate for generalized epilepsy. Additionally, newer ASMs have a lower impact on thyroid hormone profiles in children with epilepsy compared to traditional drugs. Overall, newer generation ASMs provide valuable individualized options due to their improved safety profiles, reduced drug interactions, and lower teratogenic risks, making them easier to use in various patient populations and clinical settings.

Are miRNAs useful biomarkers for the diagnosis of drug-resistant epilepsy?4 answersMicroRNAs (miRNAs) have shown potential as biomarkers for the diagnosis of drug-resistant epilepsy. Several studies have identified dysregulation of miRNAs in the brain tissue and biofluids of patients with drug-resistant epilepsy, indicating their potential as diagnostic markers. These miRNAs are enriched in the brain and have been found to be altered in patients with epilepsy compared to healthy controls. Additionally, specific miRNAs have been associated with drug-resistant epilepsy, including miRNA-155, miRNA-129-2-3p, and miRNA-153. Blood levels of brain-enriched miRNAs have been shown to be altered in patients with drug-resistant epilepsy compared to those with drug-responsive seizures, with promising sensitivity and specificity. However, further validation and larger-scale studies are needed to establish miRNAs as robust biomarkers for the diagnosis of drug-resistant epilepsy.

What is the relationship between epilepsy and cognitive impairment?5 answersEpilepsy is frequently associated with cognitive impairment, including difficulties in memory, attention, and executive function. The severity of cognitive impairment can vary depending on the type of epilepsy and the location of epileptic activity. Sleep microstructures, such as sleep spindles, have been found to be related to the severity of cognitive impairment in epilepsy. Additionally, studies have shown that cognitive decline in epilepsy may be associated with mechanisms typical of Alzheimer's disease, including the presence of tau protein and beta-amyloid deposits. Furthermore, there is emerging evidence that epilepsy and Alzheimer's disease share common features, and epilepsy patients with mild cognitive symptoms may show Alzheimer's disease-like metabolic patterns. Overall, epilepsy can have a significant impact on cognitive function, and it is important to assess and monitor cognitive impairment in individuals with epilepsy.

How similar bipolar disorder and epilepsy?4 answersBipolar disorder and epilepsy have overlapping characteristics and comorbidity. Individuals with bipolar disorder may develop epilepsy after head injuries, leading to symptoms consistent with interictal personality syndrome. A systematic review and meta-analysis found a pooled lifetime prevalence of bipolar symptoms (BS) in people with epilepsy (PWE) to be 12.3% and bipolar disorder (BD) to be 4.5%. Genetic studies have identified shared loci between epilepsy and psychiatric disorders, including bipolar disorder, schizophrenia, and depression, suggesting a complex genetic relationship. In patients diagnosed with bipolar II disorder, epileptiform discharges or other sharp activity on EEGs were associated with a higher frequency of hypomanic episodes and an increased hypomania:depression ratio. These findings suggest that epilepsy and bipolar disorder share clinical features and genetic risk, highlighting the need for further research and careful screening of individuals with epilepsy for bipolar symptoms.

What is the role of AI in epilepsy?5 answersArtificial intelligence (AI) has been applied to neuroimaging in patients with epilepsy to enhance classification of clinical diagnosis, prediction of treatment outcomes, and the understanding of cognitive comorbidities. AI-based tools have been used to develop a novel data-driven disease taxonomy based on distinct patterns of brain atrophy in epilepsy patients, which could be used for individualized prognostics and targeted therapeutics. Additionally, a propositional AI system has been developed to support physicians in the diagnosis of epilepsy by analyzing and building ontology knowledge for the classification of seizure patterns, epilepsy syndromes, and etiologies. The use of AI in epilepsy research has the potential to improve diagnosis, prognosis, and treatment outcomes for patients with epilepsy.

Is epilepsy a sign of intelligence?2 answers

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