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Is epilepsy Mirgi?

Epileptogenesis

Missense mutation

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Open access•Journal Article•DOI LncRNA NEAT1 affects inflammatory response by targeting miR-129-5p and regulating Notch signaling pathway in epilepsy Yi Wan, Zhi-Quan Yang - Show less +1 more 17 Jan 2020-Cell Cycle 44 Citations	The present study verified that lncRNA NEAT1 affected inflammatory response of epilepsy by suppressing miR-129-5p and further regulating Notch signaling pathway in IL-1β-induced epilepsy cell model.
Open access•Journal Article•DOI LGI1 mutations in autosomal dominant partial epilepsy with auditory features Ruth Ottman, Melodie R. Winawer, Sergey Kalachikov, Christie Barker-Cummings, T. C. Gilliam, Timothy A. Pedley, W. A. Hauser - Show less +6 more 13 Apr 2004-Neurology 181 Citations	This could result from either an effect of LGI1 on risk for generalized epilepsy or an effect of co-occurring idiopathic generalized epilepsy-specific genes in these families.

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Epilepsy detection from ecg?5 answersEpilepsy detection from EEG signals is a challenging task due to the labor-intensive nature of the procedure, lack of trained professionals, and inherent variability in the EEG of different patients. However, several studies have proposed automatic seizure detection systems using machine learning techniques. These systems analyze and detect seizures in single-channel EEG from multiple patients by classifying EEG instances as seizure or non-seizure based on learned features from the training set. Features extracted from the time, frequency, and time-frequency domains are combined to capture information about EEG signals' amplitude, frequency, and morphology. Experimental work has been conducted to establish the best algorithms and parameters for preprocessing, feature selection, and classification. The proposed systems have achieved high accuracy, specificity, and sensitivity, exceeding 99% and 98.9% respectively. Additionally, the use of Discrete Wavelet Transform (DWT) and machine learning classifiers has shown promising results in epilepsy detection, achieving maximum accuracy, sensitivity, specificity, precision, and recall of 100%.

What is the role of gut microbiome one epilepsy?4 answersThe gut microbiome plays a significant role in epilepsy. Studies have shown that gut dysbiosis, characterized by an imbalance in the gut microbial composition, is associated with epilepsy. Specific bacterial phyla and species have been found to be altered in the gut of epileptic patients, such as an increase in Proteobacteria, Verrucomicrobia, Fusobacteria, and Firmicutes, and a decrease in Actinobacteria and Bacteroidetes. Modulating the gut microbiota through interventions like probiotics, ketogenic diet, or fecal microbiota transplantation has shown positive effects in reducing seizure frequency and strength. Furthermore, the restoration of a healthy gut microbiota may increase the success of epilepsy treatment. However, further research is needed to fully understand the mechanisms underlying the gut-brain axis in epilepsy and to determine the effectiveness of these treatment strategies in patients.

What is the role of AI in epilepsy?5 answersArtificial intelligence (AI) has been applied to neuroimaging in patients with epilepsy to enhance classification of clinical diagnosis, prediction of treatment outcomes, and the understanding of cognitive comorbidities. AI-based tools have been used to develop a novel data-driven disease taxonomy based on distinct patterns of brain atrophy in epilepsy patients, which could be used for individualized prognostics and targeted therapeutics. Additionally, a propositional AI system has been developed to support physicians in the diagnosis of epilepsy by analyzing and building ontology knowledge for the classification of seizure patterns, epilepsy syndromes, and etiologies. The use of AI in epilepsy research has the potential to improve diagnosis, prognosis, and treatment outcomes for patients with epilepsy.

What is epilepsy?5 answersEpilepsy is a neurological disorder characterized by recurrent seizures, which are sudden, uncontrolled electrical disturbances in the brain. These seizures can cause a variety of symptoms, ranging from mild to severe, including loss of consciousness, loss of speech, uncontrollable motor behavior, and unusual sensory experiences. The exact cause of epilepsy is often unknown, but it can be due to brain damage, genetic factors, or other underlying conditions. Diagnosis of epilepsy requires a minimum of two unprovoked seizures, and it is important to distinguish a first and single seizure from epilepsy. Treatment options for epilepsy include medication, surgical interventions, and neuromodulation treatments using electrical stimulation. Epilepsy is a common condition, affecting approximately 0.5% of the population worldwide.

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