Search or ask a question

Is estrogen catabolic?

Ovariectomized rat

Estrogen receptor

Estrogen receptor beta

Luteinizing hormone

Answers from top 7 papers

PDF

Open Access

More filters

Papers (7)	Insight
Open access•Journal Article•DOI The catechol estrogen, 4-hydroxyestrone, has tissue-specific estrogen actions. KC Westerlind, KJ Gibson, G L. Evans, Russell T. Turner - Show less +3 more 01 Nov 2000-Journal of Endocrinology 19 Citations	The data suggest that the catechol estrogen, 4-OHE(1), unlike 2-OHE(1), has estrogen activity.
Journal Article•DOI Effects of Catecholestrogens on Luteinizing Hormone Levels in Long Term Ovariectomized Adult Rats P. Ball, Günter Emons, Thomas Klingebiel, Kathrin-Maria GRüHN, Rudolf Knuppen - Show less +4 more 01 Oct 1981-Endocrinology 17 Citations	It is concluded that in this model, catecholestrogens act as estrogens with respect to LH suppression and release, with 4-hydroxyestradiol being a potent estrogen and 2-hydroxyestradiol a weak estrogen.
Journal Article•DOI The negative feedback control by estradiol and progesterone of LH secretion in the ovariectomized rhesus monkey. T. Yamaji, D. J. Dierschke, A.N. Bhattacharya, Ernst Knobil - Show less +3 more 01 Mar 1972-Endocrinology 110 Citations	It is concluded that estrogen is th...
Journal Article•DOI Insulin sensitivity, hormonal levels and skeletal muscle protein metabolism in tumour-bearing exercising rats Peter Daneryd, Larsolof Hafström, E. Svanberg, Ingvar Karlberg - Show less +3 more 01 Jan 1995-European Journal of Cancer 23 Citations	This conclusion was further supported by the less catabolic pattern indicated by hormonal levels.
Journal Article•DOI Apoptotic action of estrogen. R. X.-D. Song, Richard J. Santen - Show less +1 more 01 Jan 2003-Apoptosis 109 Citations	The effects of estrogen are estrogen-receptor dependent.
Journal Article•DOI Estrogen receptor-independent catechol estrogen binding activity: protein binding studies in wild-type, Estrogen receptor-alpha KO, and aromatase KO mice tissues. Brian J. Philips, Pete J Ansell, Leslie G. Newton, Nobuhiro Harada, Shin-Ichiro Honda, Venkataseshu K. Ganjam, George E. Rottinghaus, Wade V. Welshons, Dennis B. Lubahn - Show less +8 more 01 Jun 2004-Biochemistry 23 Citations	Ligand metabolism experiments revealed extensive metabolism of labeled catechol estrogen, suggesting that catechol estrogen metabolites were responsible for the specific binding.
Journal Article•DOI 27-Hydroxycholesterol Is an Endogenous SERM That Inhibits the Cardiovascular Effects of Estrogen Michihisa Umetani Hideharu Domoto, Andrew K. Gormley, Ivan S. Yuhanna, Carolyn L. Cummins, Norman B. Javitt, Kenneth S. Korach, Philip W. Shaul, David J. Mangelsdorf - Show less +7 more 01 Mar 2008-Obstetrical & Gynecological Survey 37 Citations	Experimental studies in both animals and humans support a cardioprotective role of estrogen, but whether to administer estrogen to postmenopausal women remains controversial.

My columns

Related Questions

Does green gram have estrogen?4 answers

Does horse gram have estrogen?5 answers

Does moong dal have estrogen?4 answers

Does steroids have estrogen?6 answers

How to supplement estrogen?7 answers

Is Rice estrogenic?9 answers

See what other people are reading

What is the role of citocinas in the growth and development of MCF-7 cells?

Citocinas play a crucial role in the growth and development of MCF-7 cells. These proteins act as regulators of immune and inflammatory responses, as well as growth factors for various cell types, including hematopoietic cells. Licorice-derived flavonoid isoliquiritigenin (ILN) has been identified as an aromatase inhibitor, effectively inhibiting the growth of MCF-7 cells by targeting the cytochrome P450 19 enzyme involved in estrogen metabolism. Additionally, chitosan-coated nanoliposomes containing curcumin have shown significant growth-inhibitory effects on MCF-7 breast cancer cells, with enhanced loading efficiency and bioavailability compared to non-coated liposomes, indicating a potential role in combating cancer cell proliferation. These findings highlight the diverse mechanisms through which citocinas impact the growth and development of MCF-7 cells, offering insights into potential therapeutic strategies.Does creatine increase testosterone?

Creatine supplementation has varying effects on testosterone levels based on different studies. One study on male albino rats showed that Creatine Monohydrate® increased estrogen levels but had no effect on testosterone levels. In contrast, a study on trained men indicated that short-term creatine supplementation led to significantly higher testosterone concentrations post-exercise, suggesting an augmented anabolic hormone response. Another study on men undergoing resistance training found that creatine supplementation did not affect resting testosterone levels but helped maintain muscular performance during high-volume training. Additionally, research has debunked concerns linking creatine to cancer risk, showing that creatine supplementation did not increase the formation of carcinogenic compounds related to cancer. Therefore, while creatine may impact estrogen levels and exercise-induced testosterone responses, its overall effect on resting testosterone levels and cancer risk appears to be minimal.Howsignalling from the nucleus to mitochondria (NM signalling)

Nucleus-to-mitochondria (NM) signaling is a critical aspect of cellular communication, ensuring the coordination of cellular functions and responses to various stimuli. This signaling pathway, often referred to as anterograde signaling, primarily involves the transmission of signals from the nucleus to mitochondria to regulate mitochondrial function based on the cell's metabolic needs and stress responses. The majority of mitochondrial proteins are encoded by nuclear DNA, necessitating a robust NM signaling mechanism to control their expression, import into mitochondria, and assembly into functional complexes. One of the key mechanisms of NM signaling includes the regulation of gene expression in the nucleus, which dictates the synthesis of mitochondrial proteins. These proteins are then imported into mitochondria to support their biogenesis, energy production, and other essential functions. Estrogens, for example, modulate cardiovascular function through NM signaling pathways, highlighting the role of genomic and non-genomic pathways mediated by estrogen receptors in this communication. Additionally, the action of non-coding RNAs, particularly microRNAs (miRNAs) and tRNA-derived small fragments, has emerged as a novel aspect of NM signaling. These small non-coding RNAs act as messengers in the complex regulatory mechanisms involving signaling pathways between mitochondria and the nucleus. Mitochondrial dysfunction can trigger retrograde signaling, where mitochondria communicate their status to the nucleus to initiate compensatory responses. However, NM signaling plays a crucial role in maintaining mitochondrial function by regulating the expression of nuclear-encoded mitochondrial proteins. Furthermore, NM signaling is implicated in various cellular processes, including the response to metabolic stress, where it influences the activity of mitochondrial metabolic enzymes and nuclear transcriptional machineries. In the context of disease, disruptions in NM signaling pathways can contribute to pathological conditions, underscoring the importance of understanding these mechanisms. In summary, NM signaling is a multifaceted process involving the regulation of gene expression, the involvement of non-coding RNAs, and the modulation of mitochondrial function through nuclear-encoded proteins. This communication is essential for cellular homeostasis, adaptation to stress, and the regulation of metabolic processes.What supplements have been proven to help with low estradiol levels?

Supplements that have shown potential in addressing low estradiol levels include Andrographis paniculata, soy isoflavones, and alfalfa-based supplements. Andrographis paniculata combined with low-dose estradiol demonstrated improvements in glucose and lipid homeostasis in a type-2 diabesity mice model. Additionally, soy isoflavones and alfalfa ingredients in dietary supplements exhibited high estrogenic activities, potentially aiding in alleviating menopausal symptoms and treating osteoporosis. Calcium supplementation has also been linked to increased estradiol levels in rats with calcium restriction and estrogen deficiency, leading to a reduction in bone loss. Furthermore, low-dose calcium supplements were found to enhance the effects of estrogen therapy in postmenopausal women, resulting in increased bone mineral density over time.How sexual maturity is important in swine breeding industry?

Sexual maturity plays a crucial role in the swine breeding industry by influencing reproductive success and overall welfare. Studies have shown that early puberty in gilts is associated with improved long-term reproductive performance. Factors such as hormonal priming affect the development of ovarian follicles and steroidogenic enzymes, impacting the reproductive process. Genetic markers related to sexual maturity traits have been identified, offering insights into the genetic basis for testicular maturation and enhancing reproductive traits through molecular breeding. Additionally, the impact of sexual maturity on the behavior and welfare of female pigs has been studied, highlighting the importance of managing sexual maturity to mitigate issues like lameness and aggressive behaviors. Overall, understanding and managing sexual maturity are essential for optimizing breeding outcomes and ensuring animal welfare in the swine industry.What are pharmacometric implication of tamoxifen metabolism?

Tamoxifen's pharmacometric implications stem from its metabolism, primarily by cytochrome P450 (CYP) enzymes, leading to the formation of active metabolites like endoxifen, crucial for its antiestrogenic effects. Genetic variations in CYP enzymes, especially CYP2D6, influence the conversion of tamoxifen to active metabolites, impacting treatment outcomes. Factors like CYP2D6 genotype, concomitant medications affecting CYP2D6 activity, and other genetic polymorphisms (e.g., CYP3A4*22, CYP2C19*2) play a significant role in determining plasma concentrations of active metabolites like endoxifen. Understanding these pharmacogenetic variations is crucial for tailoring tamoxifen therapy to individual patients, potentially optimizing treatment efficacy and minimizing adverse effects.How does hormonal imbalance during menopause affect overall well-being and quality of life?

Hormonal imbalance during menopause significantly impacts overall well-being and quality of life. The reduction in sex hormones like estrogen and progesterone leads to various symptoms affecting physical, psychological, and sexual health. Menopausal symptoms such as hot flushes, night sweats, weight gain, and decreased sexual functioning negatively influence daily activities and sleep quality, diminishing quality of life. Studies show that menopausal women with cardiovascular disease have lower estrogen and progesterone levels but higher total testosterone levels, indicating a hormonal imbalance that contributes to health issues and impacts overall well-being. Understanding these hormonal changes is crucial for developing targeted therapies to improve the quality of life for menopausal women.How do oestrogen levels impact physical attractiveness in females?

Oestrogen levels play a significant role in influencing physical attractiveness in females. Research indicates that higher oestrogen levels are associated with increased self-perceived desirability, physical attractiveness, and inclinations towards opportunistic mating. Additionally, high oestrogen levels have been linked to perceived age, attractiveness, enhanced skin health, and facial coloration in women, highlighting the positive impact of oestrogen on dermal health and youthful appearance. Furthermore, studies have shown positive correlations between late follicular oestrogen levels and ratings of femininity, attractiveness, and health in women's faces, suggesting that female facial appearance carries cues to reproductive health that are considered attractive by others. Moreover, during periods of high oestrogen, female intrasexual competition increases, leading to lower ratings of female facial attractiveness, supporting the theory of competition and derogation based on attractiveness.How effective are anabolic androgen steroids in treating sarcopenia in elderly patients?

Anabolic-androgenic steroids (AAS) show promise in treating sarcopenia in elderly patients. While exercise training is a common approach, AAS can enhance physical function and muscle mass, especially in individuals intolerant to exercise. Studies have demonstrated that testosterone therapy alongside resistance exercise training (RET) significantly increases muscle mass, strength, and performance in older men, highlighting the efficacy of AAS in improving skeletal muscle outcomes. However, it is crucial to consider the individual patient's clinical condition when deciding on AAS treatment, as the balance between risks and benefits may vary. Overall, AAS, particularly testosterone, can be an effective short-term intervention to combat sarcopenia in non-hypogonadal elderly men, emphasizing the potential of AAS in managing this condition.How does female sex hormone imbalance affect immune sensitivity?

Female sex hormone imbalance can significantly impact immune sensitivity. Estrogens and progesterone, secreted during the menstrual cycle, modulate immune cells in the female reproductive tract, creating vulnerability to infections during certain phases. In autoimmune diseases like systemic lupus erythematosus (SLE), where estrogen receptors play a crucial role, alterations in ERα and ERβ expression in T cells can affect lymphocyte sensitivity to estrogen, influencing immune responses. Sex hormones, including estrogens, progesterone, and testosterone, lead to a sexual dimorphism in immune responses, with females exhibiting more vigorous immune reactions and higher susceptibility to autoimmune diseases. During pregnancy, hormonal changes regulate immune cell function to prevent rejection of the fetus, highlighting the intricate balance between sex hormones and immune responses. Androgens and androgen receptor expression also play a role in modulating immune responses, potentially affecting autoimmune disease incidences and progression.Has oral tetrahydrocannabinol an impact on oestrogen synthesis?

Oral tetrahydrocannabinol (THC) has been shown to impact estrogen synthesis through various mechanisms. Studies have indicated that THC possesses antiestrogenic activity by disrupting estrogen receptor α (ERα) signaling. Additionally, THC has been found to inhibit 17β-estradiol (E2)-induced cell proliferation in ERα-positive breast cancer cells by up-regulating ERβ, a repressor of ERα activity. Furthermore, THC has been demonstrated to inhibit FSH-stimulated progesterone and estrogen biosynthesis in ovarian granulosa cells, affecting steroidogenesis essential for follicular maturation. These findings suggest that THC can interfere with estrogen synthesis and signaling pathways, potentially leading to disruptions in hormonal balance and ovarian function.