Is graphene oxide hazardous?
Answers from top 10 papers
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| Papers (10) | Insight |
|---|---|
| FROM THE CLINICAL EDITOR Exposure to graphene oxide may pose toxic effects to health, as suggested in animal studies. | |
| In striking contrast, graphene oxide is non-toxic for “bulk” cancer cells (non-stem) and normal fibroblasts. | |
111 Citations | Besides, graphene oxide has a negative effect on the biological treatment. |
| It is possible that graphene oxide can cause multigenerational harmful effects. | |
48 Citations | HIGHLIGHTSReduced Graphene Oxide & Graphene Oxide can cause potential environmental hazards. Mechanism of ocular toxicity of the materials is complex but not to be identified. Short‐term exposure tests indicate: Graphene Oxide has apparent ocular toxicity. |
27 Citations | In summary, graphene oxide is dose-dependently cytotoxic to cultured RPMI 8226 cells, and its toxicity is closely associated with increased oxidative stress. |
357 Citations | Graphene, graphene oxide, and reduced graphene oxide elicit toxic effects both in vitro and in vivo, whereas surface modifications can significantly reduce their toxic interactions with living systems. |
27 Citations | Importantly, similar to previously reported graphene inhalation data, this short-term nose-only inhalation study found only minimal or unnoticeable graphene oxide toxicity in the lungs and other organs. |
216 Citations | Graphene oxide shows stress-induced toxicity properties in vivo under different pathophysiological conditions. |
36 Citations | The high cytocompatibility of graphene oxide has confirmed its low toxicity and hence its excellent biocompatibility. |
Related Questions
Can graphene oxide have a bactericidal effect on diabetic foot ulcers?5 answersGraphene oxide (GO) exhibits strong antibacterial properties and has been explored for various applications, including wound healing. Studies have shown that the antibacterial activity of GO is enhanced when combined with antimicrobial agents like polymyxin B (PMB). Additionally, the physicochemical properties of GO play a crucial role in triggering toxic events in bacteria, leading to bactericidal effects. Proteomic analysis of Staphylococcus aureus treated with GO revealed that its bactericidal action is attributed to its ability to induce reactive oxygen species (ROS), disrupt cell membranes, and alter protein expression. Furthermore, GO has been utilized in photothermal therapy (PTT) and photodynamic therapy (PDT) to effectively eliminate bacteria, showcasing its potential for disinfection in medical applications. Therefore, the bactericidal effect of GO makes it a promising candidate for combating bacterial infections in diabetic foot ulcers.
What are the challenges in using graphene oxide?4 answersGraphene oxide (GO) has shown remarkable improvements in the strength and durability of concrete, making it a promising material for next-generation concrete structures. However, there are still challenges in using graphene oxide. One challenge is the degradation of graphene at high temperatures in the presence of oxygen, which limits its application in device fabrication. Another challenge is the need to systematically assess the biocompatibility, toxicity, and other surface properties of graphene-based structures for biomedical applications. Additionally, the zero band gap of graphene poses a challenge for controlling current flow through electrical gating, limiting its practical applications in electronics. Finally, the synthesis of graphene and graphene oxide can be expensive, limiting their economic feasibility for certain applications such as bioelectricity production in microbial fuel cells.
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