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Is influenza caused by a RNA virus? 

RNA-dependent RNA polymerase
RNA
Polymerase
Virus
Influenza A virus

Answers from top 10 papers

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Papers (10)Insight
Open access•Journal Article•DOI
Mini viral RNAs act as innate immune agonists during influenza virus infection
Aartjan J. W. te Velthuis, Aartjan J. W. te Velthuis, Joshua C. D. Long, David L.V. Bauer, Rebecca L. Y. Fan, Hui-Ling Yen, Jane Sharps, Jurre Y. Siegers, Marian J. Killip, Marian J. Killip, Hollie French, Maria José Oliva-Martín, Richard E. Randall, Emmie de Wit, Debby van Riel, Leo L.M. Poon, Ervin Fodor 
17 Sep 2018-Nature microbiology
89 Citations
We propose that mvRNAs act as the main agonists of RIG-I during influenza virus infection. Aberrant mini viral RNAs, which are produced by erroneous RNA polymerase activity during the replication of the viral RNA genome, act as the main agonists of RIG-I during influenza virus infection.
Open access•Journal Article•DOI
Artificial Hybrids of Influenza A Virus RNA Polymerase Reveal PA Subunit Modulates Its Thermal Sensitivity
Takahito Kashiwagi, Koyu Hara, Yoko Nakazono, Nobuyuki Hamada, Hiroshi Watanabe 
07 Dec 2010-PLOS ONE
20 Citations
s/Significance These findings suggested that influenza A virus may acquire an RNA polymerase adapted to different body temperatures of the host by reassortment of the RNA polymerase genes.
Journal Article•DOI
Influenza virus, an RNA virus, synthesizes its messenger RNA in the nucleus of infected cells.
Carolyn Herz, Edward Stavnezer, Robert M. Krug, Theodore Gurney 
01 Nov 1981-Cell
205 Citations
Influenza virus is thus unique among nononcogenic RNA viruses in synthesizing its mRNA in the nucleus.
Open access•Journal Article•DOI
1918 Influenza virus hemagglutinin (HA) and the viral RNA polymerase complex enhance viral pathogenicity, but only HA induces aberrant host responses in mice.
Tokiko Watanabe, Jennifer Tisoncik-Go, Nicolas Tchitchek, Shinji Watanabe, Arndt Benecke, Arndt Benecke, Michael G. Katze, Yoshihiro Kawaoka 
01 May 2013-Journal of Virology
35 Citations
Taken together, these data suggest that HA and the viral RNA polymerase complex are critical determinants of Spanish influenza pathogenesis, but only HA, and not the viral RNA polymerase complex and NP, is responsible for extreme host responses observed in mice infected with the 1918 influenza virus.
Journal Article•DOI
Nuclear traffic of influenza virus proteins and ribonucleoprotein complexes.
Sébastien Boulo, Hatice Akarsu, Rob W.H. Ruigrok, Florence Baudin 
01 Mar 2007-Virus Research
231 Citations
Influenza virus is a negative strand RNA virus and is one of the rare RNA viruses to replicate in the nucleus.
Open access•Journal Article•DOI
Model Suggesting that Replication of Influenza Virus Is Regulated by Stabilization of Replicative Intermediates
Frank T. Vreede, Tanis E. Jung, George G. Brownlee 
01 Sep 2004-Journal of Virology
218 Citations
We demonstrate that, in the presence of preexisting viral RNA polymerase and nucleoprotein (NP), influenza A virus synthesizes both mRNA (transcription) and cRNA (replication) early in infection.
Open access•Journal Article•DOI
Packaging of the Influenza Virus Genome Is Governed by a Plastic Network of RNA- and Nucleoprotein-Mediated Interactions.
Hardin Bolte, Miruna E. Rosu, Miruna E. Rosu, Elena Hagelauer, Adolfo García-Sastre, Martin Schwemmle 
05 Feb 2019-Journal of Virology
34 Citations
Along with previous reports, our data propose that influenza A virus uses a redundant and plastic network of RNA-RNA and potentially RNA-nucleoprotein interactions to coordinately incorporate its segmented genome into virions.
Open access•Journal Article•DOI
A defective interfering influenza RNA inhibits infectious influenza virus replication in human respiratory tract cells : a potential new human antiviral
Claire Smith, Paul D. Scott, Christopher O'Callaghan, Andrew J. Easton, Nigel J. Dimmock 
22 Aug 2016-Viruses
19 Citations
In this study we hypothesise that a cloned DI influenza A virus RNA may prevent infection of human respiratory epithelial cells with infection by influenza A.
Open access•Journal Article•DOI
Inhibition of influenza virus production in virus-infected mice by RNA interference
Qing Ge, Lily Filip, Ailin Bai, Tam Nguyen, Herman N. Eisen, Jianzhu Chen 
08 Jun 2004-Proceedings of the National Academy of Sciences of the United States of America
464 Citations
Here, we show that short interfering RNAs (siRNAs) specific for conserved regions of influenza virus genes can prevent and treat influenza virus infection in mice.
Open access•Journal Article•DOI
The role of the influenza virus RNA polymerase in host shut-off.
Frank T. Vreede, Ervin Fodor 
01 Sep 2010-Virulence
45 Citations
These findings extend our understanding of how influenza virus counteracts antiviral host responses and underpin studies into the mechanisms by which the RNA polymerase determines virulence.

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