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Is it safe to take collagen and zinc together? 

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The results show that zinc does not have a direct acceleratory effect on either cellular proliferation or collagen biosynthesis in human skin fibroblasts in vitro.
It is concluded that collagenase is a zinc metalloenzyme that forms an inactive and unstable apoenzyme on treatment with chelators.
Zinc can prevent collagen hydrolysis by MMPs.
Neither inhibition of polysomal protein synthesis nor increased degradation of mature collagen fibers was found to play any major role in the effect of zinc.
At the same time, it is necessary to investigate and research further these toxicities of zinc with long-term administration of low dosage.
The results of this study suggest that most of the zinc atoms detected were attached to hydroxyapatite and not to collagen.
The present data suggest that peroral zinc treatment has a direct and selective inhibitory effect on carbon tetrachloride-induced collagen accumulation in rat liver.