Is lack of iron a risk factor for developing cancer?
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48 Citations | Iron could be a relevant risk factor for carcinogenesis since it catalyses the formation of reactive oxygen species (ROS), which damage DNA. |
313 Citations | Dysregulation of iron metabolism can increase cancer risk and promote tumor growth. |
164 Citations | HighlightsMyriads of oxidative stress is a risk for cancer. Excess iron is linked with cancer in human epidemiology and in animal experiments. Cancer cells are under oxidative stress but with tolerance against oxidative stress. Cancer cells harbor increased iron pool with resistance to ferroptosis. L‐Ascorbate, non‐thermal plasma and glucose/Q depletion may hit fragility of cancer. |
52 Citations | Iron deficiency causes anaemia, whereas excessive iron increases cancer risk, presumably by free radical generation. |
152 Citations | These data, which indicate lower risk of cancer in iron‐depleted women, lend epidemiologic support to the hypothesis that high iron stores may increase cancer risk, at least for lung cancer. |
256 Citations | Iron reduction was associated with lower cancer risk and mortality. |
24 Citations | Reversed causality due to early disease giving symptoms of iron shortage, resulting in iron supplementation, is an issue to consider when a possible association between intake of iron and cancer risk is investigated. |
65 Citations | Given the preliminary but consistent evidence relating iron deficiency to cancer risk and the fact that iron deficiency affects about one third of the world's population, further studies are needed to define the extent to which iron deficiency might increase GI cancer risk. |
Open access•Journal Article 32 Citations | BACKGROUND Dietary iron and zinc affect the risk of cancer, with dietary iron generally correlated with increased risk and dietary zinc with reduced risk. |
65 Citations | In particular, high available iron status may increase the risk of a radiation-induced cancer. |
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What is the relationship between vitamin B9 and B12 deficiency and cancer risk?5 answersVitamin B9 (folate) and B12 deficiencies have been associated with cancer risk in various studies. Low serum levels of folate and vitamin B12 have been linked to an increased risk of high-risk human papillomavirus (hrHPV) infection, particularly in women in the United States. Additionally, elevated plasma folate concentrations have shown a positive relationship with colorectal cancer risk, especially in subjects with higher tumor stages or shorter follow-up times. Conversely, plasma vitamin B12 concentrations have been inversely associated with rectal cancer risk. These findings suggest that maintaining adequate levels of vitamin B9 and B12 may play a role in reducing the risk of certain cancers, highlighting the importance of addressing potential deficiencies in these essential vitamins for cancer prevention.
What are the deficiencies of Iron?4 answersIron deficiency is a prevalent global health concern affecting various populations, including infants, children, pregnant women, and adults. Iron deficiency can lead to anemia, psychomotor disorders, poor health outcomes, and behavioral changes. The causes of iron deficiency include inadequate dietary intake, increased iron requirements, bleeding, and absorption disorders. Symptoms of iron deficiency range from anemia-related issues to neurodevelopmental impairments and skin, hair, nail, and gastrointestinal problems. Iron is essential for hemoglobin synthesis, cell regulation, DNA synthesis, and mitochondrial electron transport. Iron deficiency anemia is linked to adverse outcomes like preterm delivery, low birth weight, and inferior neonatal health. Addressing iron deficiency through public health interventions like fortification of staple foods can help prevent and treat this widespread nutritional disorder.
Does Falconi anemia increase the risk of developing cancer?4 answersFanconi anemia (FA) is a rare genetic disorder that increases the risk of developing cancer. FA is associated with alterations in at least 22 genes involved in DNA repair, particularly interstrand DNA crosslink repair. Individuals with FA have a higher susceptibility to DNA cross-linking substances and are at increased risk for a variety of solid tumors. Lung squamous cell carcinoma (SqCC) is one type of cancer that has been found to be enriched in FA genes, including BRCA2. The risk of developing cancer, including esophageal cancer, is higher in FA patients after the age of 20. Routine cancer screening and preventive interventions, such as HPV vaccination, are recommended for individuals with FA. Overall, FA increases the risk of developing cancer, and early detection and personalized programs can improve prognosis.
What are the different causes of iron deficiency?5 answersIron deficiency can be caused by inadequate intake of iron, early childhood growth and development, pregnancy, small but repeated bleeding, abundant menstruation, metrorrhages, fibroids, gastric or duodenal ulcer, hemorrhoidal disease, oncological pathology, malabsorption syndromes, inflammatory bowel diseases, parasitosis, and chronic diseases such as chronic heart failure, chronic kidney disease, inflammatory bowel syndromes, and cancer. Other causes include inadequate dietary iron intake, increased iron requirements, bleeding, and intestinal iron absorption disorders. In women, iron deficiency can be due to poor dietary intake and menstruation. In developing countries, poor iron intake, parasitic infection, inadequate diets, low iron intestinal absorption, chronic blood losses, and increased requirements are common causes.
What are the main causes of iron deficiency?5 answersIron deficiency can be caused by inadequate intake of iron, early childhood growth and development, pregnancy, small but repeated bleeding, abundant menstruation, metrorrhages, fibroids, gastric or duodenal ulcer, hemorrhoidal disease, oncological pathology, malabsorption syndromes, inflammatory bowel diseases, and parasitosis. Other causes include inappropriate intestinal absorption, improper iron storage and utilization, and inappropriate or excessive blood loss. The main etiologies of iron deficiency are blood loss due to menstrual periods and gastrointestinal bleeding. Poor iron intake linked to inadequate diets, low iron intestinal absorption, chronic blood losses, and increased requirements are common causes in high-income countries.
What are the genetic factors associated with iron deficiency?5 answersIron deficiency is influenced by genetic factors. The SNP rs2698530 on chr 2p14, rs3811647 on chr 3q22 in the TF gene region, rs1800562 on chr 6p22 in the HFE gene, rs7787204 on chr 7p21, and rs987710 on chr 22q11 are associated with iron deficiency. In addition, the SNP rs1421312 in the TMPRSS6 gene is associated with serum iron levels in whites and African Americans. Variants in the genes TMPRSS6, BTBD9, and BMP2 are associated with ferritin levels in Australian blood donors. Furthermore, SNPs in the TF and TMPRSS6 genes, as well as loci on chromosome 18q21, are associated with iron-related outcomes in multiple populations. These findings suggest that genetic testing and identification of specific SNPs can help predict susceptibility or resistance to iron deficiency and inform tailored management strategies.