scispace - formally typeset
Search or ask a question

Answers from top 4 papers

More filters
Papers (4)Insight
These effects may lead to improvements in the treatment of kidney disease.
AIM Dietary modification is integral to the management of end stage kidney disease.
Therefore, this treatment may represent a therapeutic approach for the management of kidney disease.
Open accessJournal ArticleDOI
43 Citations
Taken together, these experimental studies suggest an important role of oxidants in chronic kidney disease.

See what other people are reading

Is Glutathione supplements the same as GlyNAC?
5 answers
How can family physicians help prevent dialysis-related complications?
5 answers
3.What is the function of nitrite?
4 answers
What are the primary responsibilities of a family physician in the healthcare of dialysis patients?
5 answers
How does family physician's role differ in managing dialysis-related amyloidosis compared to other healthcare professionals?
5 answers
How can family physicians help prevent dialysis-related complications?
5 answers
3.What is the function of nitrite?
4 answers
What health care policies impact patient care management?
5 answers
Is omega 3 helpful in reducing period cramps?
5 answers
What are the potential therapeutic implications of targeting creatine metabolism in acidosis treatment?
5 answers
Targeting creatine metabolism in acidosis treatment holds therapeutic promise. Creatine treatment has shown antioxidant effects, enhancing tissue resistance to acidosis by stimulating (Na+/K+)-ATPase expression. In chronic kidney disease (CKD), metabolic acidosis is a common complication, leading to adverse outcomes. Studies suggest that alkali therapy, such as sodium bicarbonate supplementation, can improve kidney function and slow CKD progression. In colorectal cancer (CRC), dysregulated glycolytic pathways contribute to tumor acidosis. Inhibiting creatine import with RGX-202 induces tumor cell apoptosis and suppresses tumor growth, offering a potential strategy for CRC treatment. These findings highlight the diverse implications of targeting creatine metabolism in managing acidosis-related conditions like CKD and CRC.
Whta is the juctacrin coonection?
5 answers
Juxtanodin (JN) is a protein with diverse roles in different tissues. Initially identified in the central nervous system and olfactory neuroepithelium, JN is also expressed in the retinal pigment epithelium (RPE) of the retina. In the RPE, JN is prominently found at the apices and bases of cells, where it partially co-localizes with F-actin, indicating a role in cytoskeletal organization. Furthermore, in vitro studies using a human RPE cell line suggest that JN up-regulation promotes actin stress fiber formation, F-actin redistribution, and cell spreading/enlargement, hinting at potential functions in molecular transport, phagocytosis, and blood-retinal barrier formation. This protein's varied expression and functions across different tissues underscore its importance in cellular processes and potential implications in retinal disorders.