Is necrosis considered safer than apoptosis?
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106 Citations | Apoptosis circumvents the induction of an inflammatory response, which can be disadvantageous and, therefore, would be more beneficial than necrosis under many circumstances. |
18 Citations | Our results are in accordance with the idea that apoptosis rarely precedes necrosis. |
| Apoptosis, in contrast to necrosis, is not harmful to the host and does not induce any inflammatory reaction. | |
209 Citations | The distinction between apoptosis and necrosis, is not simply a problem of terminology; if necrosis and apoptosis are different from a mechanistic point of view, and if necrosis is merely the passive result of cellular injury (still to be shown), it becomes critical to discriminate between the two processes, in order to understand how to modulate apoptosis in view of its potential therapeutic use. |
103 Citations | Contrary to necrosis, an accidental form of cell death, apoptosis does not induce inflammatory reaction noxious for the vicinity. |
104 Citations | Therefore, necrosis, similarly to apoptosis, is suggested to be a form of the programmed cell death. |
87 Citations | The former, apoptosis, by definition, is a controlled event; thereby offering the potential for intervention, whereas necrosis is a more stochastic process. |
| In contrast to necrosis, apoptosis is not commonly accompanied by an inflammatory response that causes collateral cell damage. | |
704 Citations | Therefore, necrosis, along with apoptosis, appears to be a specific form of execution phase of programmed cell death, and there are several examples of necrosis during embryogenesis, a normal tissue renewal, and immune response. |
373 Citations | This suggests that apoptosis and necrosis may not be mutually exclusive modes of cell death. |
Related Questions
What is type of necrosis?4 answersNecrosis is a form of cell death that occurs as a result of encounters with noxious stimuli, such as infectious agents, oxygen deprivation, extreme environmental conditions, or irreversible injury. There are several types of necrosis, including liquefactive necrosis, coagulative necrosis, caseous necrosis, fat necrosis, gangrenous necrosis, and fibrinoid necrosis. Liquefactive necrosis is characterized by the partial or complete dissolution of dead tissue into a liquid, viscous mass, while coagulative necrosis maintains the normal architecture of necrotic tissue for several days. Caseous necrosis is a unique type of cell death seen with tuberculosis, and fat necrosis occurs from acute inflammation affecting tissues with numerous adipocytes. Gangrenous necrosis and fibrinoid necrosis are also observed in specific clinical scenarios or organ damage.
What is tumour necrosis?5 answersTumour necrosis refers to the death of cells within a tumor. It is a common histological feature seen in various cancers and is often associated with poor prognosis. The mechanism underlying tumor necrosis is not fully understood, but it is believed to be a result of metabolic stress and inflammation leading to oxidative stress-induced cell death, such as ferroptosis. Immune cells, such as neutrophils, can also contribute to tumor necrosis by triggering ferroptosis in tumor cells. Tumour necrosis factor (TNF) is a pro-inflammatory cytokine that has been implicated in metabolic inflammation and obesity-associated metabolic disease. Different types of necrosis, including granular necrosis, have been identified based on their morphological features and pathogenesis. Necroptosis, a form of programmed necrosis, has been found to occur in advanced solid tumors and may have both tumor-promoting and tumor-suppressing effects. Tumour necrosis is also used as a prognostic marker in pancreatic cancer patients.
Is euthanasia appropriate?5 answersEuthanasia is a complex issue that requires careful consideration. The ethics of euthanasia in wildlife rehabilitation emphasize the importance of animal welfare and the animal's best interest. In laboratory rodents, the choice of euthanasia method should minimize pain and distress while also considering scientific goals, guidelines, and the proficiency of personnel. Veterinarians play a crucial role in ensuring humane treatment and relief of animal suffering, including the humane taking of animal life. Anesthesia is essential in laboratory animal experimentation to ensure analgesia and reversible loss of consciousness, and guidelines for euthanasia methods are also highlighted. When it comes to small ruminants, selecting a safe and humane method of field euthanasia can be challenging, but options such as gunshot, captive bolt, and carbon dioxide inhalation can be effective. Overall, the appropriateness of euthanasia depends on the specific circumstances and the consideration of animal welfare and ethical guidelines.
What are the main challenges in inducing necroptosis as a cancer treatment strategy?5 answersThe main challenges in inducing necroptosis as a cancer treatment strategy include apoptosis resistance and immunological silence, technical barriers in detecting ongoing necroptosis in vivo, downregulation of key regulators of the necroptotic pathway in cancer cells, potential inflammatory response and immunosuppressive tumor microenvironment, conflicting evidence on the role of necroptosis in cancer progression and metastasis, and concerns about selectivity in killing cancer cells without harming normal cells and the potential for inflammatory diseases.
How does fas receptor induced regulated necrosis?2 answersFas receptor-induced regulated necrosis involves a switch between apoptotic and necrotic cell death, with caspase-independent necrotic cell death being induced by Fas. The death effector domain of FADD, the central adaptor molecule for Fas receptors, directly interacts with both TRAIL and Fas/CD95 receptors, leading to FADD recruitment and caspase activation. Fas-induced apoptosis signaling is mediated by FADD-mediated recruitment and activation of caspase-8, with amplification through proteolytic activation of BID in certain cells. FasL-induced cell death and phosphatidylserine externalization can be prevented by caspase inhibitors, and Fas-induced cell death can occur through both caspase-3-dependent apoptosis and caspase-8-dependent necrosis, with delayed elevation of ceramide promoting necrosis. Fas-induced apoptosis signaling requires recruitment and activation of caspase-8, and in type 2 cells, amplification of the caspase cascade through proteolytic activation of BID leads to mitochondrial outer membrane permeabilization and release of apoptogenic proteins.
Is diabetes deadly?2 answersDiabetes is a chronic and debilitating disease that is associated with a range of complications and is a major cause of death globally. Patients with diabetes have a higher risk of acute cardiovascular events, including stroke, and experience poorer long-term outcomes after stroke compared to those without diabetes. Diabetes also increases the risk of developing chronic heart failure and is associated with a significantly increased risk of death. Additionally, diabetes can impede efforts to control tuberculosis, with diabetic tuberculosis patients having greater clinical severity, lung involvement, and residual changes compared to non-diabetic patients. Strict glycemic control in diabetic tuberculosis patients enhances sputum clearance and improves patient outcomes. Therefore, diabetes can be considered deadly due to its association with increased mortality and the higher risk of complications and poor outcomes in various diseases.