Thus the loss of ATP-dependence of RNA release observed earlier in several non-neural cell-types after exposure to carcinogens, or after neoplastic transformation, is not an essential attribute of the carcinogenic process.

Its inhibition may thus be carcinogenic.

Bulk RNAseq of environmentally-induced mouse tumors can reveal carcinogenic exposures and causes.

It is suggested that UV-induced disruption of miRNA-mediated gene regulation plays a carcinogenic role.

Small interfering RNA (siRNA) has the ability to knock down the expression of carcinogenic genes or drug efflux transporter genes, paving the way for cancer treatment.

We hypothesize that lncRNAs have potential as epigenetic biomarkers of carcinogenic exposures.

Gene ontology analysis indicated that most commonly-altered mRNAs participate in carcinogenic steps.

Thus, alterations in methylation contribute directly to the carcinogenic potential of the cells.

It is proposed that alterations of minor nucleotides in the maturation of tRNA could be basic to the carcinogenic process.

It is indicated that RNAi application for targeting functional carcinogenic molecules, tumor resistance to chemotherapy and radiotherapy is required in cancer treatment.

Is RNA carcinogenic? | 10 Answers from Research papers

Papers (10)	Insight
Journal Article•DOI Characteristics of RNA release from rat brain nuclei and effect of neurocarcinogenesis. Ming J.W. Chang, A. Koestner, Thomas Palayoor, Dorothy E. Schumm, Thomas E. Webb - Show less +4 more 27 Feb 1980-Biochemical and Biophysical Research Communications 7 Citations	Thus the loss of ATP-dependence of RNA release observed earlier in several non-neural cell-types after exposure to carcinogens, or after neoplastic transformation, is not an essential attribute of the carcinogenic process.
Journal Article•DOI Cadmium(II), unlike nickel(II), inhibits 8-oxo-dGTPase activity and increases 8-oxo-dG level in DNA of the rat testis, a target organ for cadmium(II) carcinogenesis. Karol Bialkowski, Aneta Bialkowska, Kazimierz S. Kasprzak - Show less +2 more 01 Aug 1999-Carcinogenesis 41 Citations	Its inhibition may thus be carcinogenic.
Proceedings Article•DOI Mutational RNA signatures in environmentally-induced lung adenocarcinoma Georgia A. Giotopoulou, Sabine J. Behrend, Giannoula Ntaliarda, Anne-Sophie Lamort, Mario A.A. Pepe, Ioannis Lilis, M Spella, Georgios T. Stathopoulos - Show less +7 more 11 Mar 2021-Lung Cancer	Bulk RNAseq of environmentally-induced mouse tumors can reveal carcinogenic exposures and causes.
Open access•Journal Article•DOI Mutagen-specific mutation signature determines global microRNA binding. Eyal Greenberg, Gideon Rechavi, Ninette Amariglio, Oz Solomon, Oz Solomon, Jacob Schachter, Gal Markel, Gal Markel, Eran Eyal - Show less +8 more 09 Nov 2011-PLOS ONE 10 Citations	It is suggested that UV-induced disruption of miRNA-mediated gene regulation plays a carcinogenic role.
Open access•Journal Article•DOI Nanoparticle-mediated co-delivery of chemotherapeutic agent and siRNA for combination cancer therapy Bo Xiao, Lijun Ma, Didier Merlin - Show less +2 more 01 Jan 2017-Expert Opinion on Drug Delivery 79 Citations	Small interfering RNA (siRNA) has the ability to knock down the expression of carcinogenic genes or drug efflux transporter genes, paving the way for cancer treatment.
Open access•Journal Article•DOI Differential Expression of Long Noncoding RNAs in the Livers of Female B6C3F1 Mice Exposed to the Carcinogen Furan Leslie Recio, Suzanne L. Phillips, Timothy Maynor, Michael D. Waters, Anna Francina Jackson, Anna Francina Jackson, Carole L. Yauk - Show less +6 more 01 Oct 2013-Toxicological Sciences 29 Citations	We hypothesize that lncRNAs have potential as epigenetic biomarkers of carcinogenic exposures.
Open access•Journal Article•DOI Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis Ainhoa Lapitz, Ander Arbelaiz, Colm J O'Rourke, José Luis Lavín, Adelaida La Casta, C. Ibarra, J.P. Jimeno, Alvaro Santos-Laso, Laura Izquierdo-Sanchez, Laura Izquierdo-Sanchez, Marcin Krawczyk, Maria J. Perugorria, Maria J. Perugorria, Raul Jimenez-Agüero, A. Sanchez-Campos, Ioana Riaño, Esperanza Gonzalez, Frank Lammert, Marco Marzioni, Rocio I.R. Macias, Jose J.G. Marin, Tom H. Karlsen, Luis Bujanda, Luis Bujanda, Juan M. Falcón-Pérez, Juan M. Falcón-Pérez, Jesper B. Andersen, Ana M. Aransay, Pedro M. Rodrigues, Jesus M. Banales, Jesus M. Banales, Jesus M. Banales - Show less +31 more 14 Mar 2020-Cells 58 Citations	Gene ontology analysis indicated that most commonly-altered mRNAs participate in carcinogenic steps.
Journal Article•DOI Tumour-associated hypermethylation: silencing E-cadherin expression enhances invasion and metastasis. L. Di Croce, Pier Giuseppe Pelicci - Show less +1 more 01 Mar 2003-European Journal of Cancer 22 Citations	Thus, alterations in methylation contribute directly to the carcinogenic potential of the cells.
Open access•Journal Article The Alkylation of Transfer RNA by Enzymes from Embryonic, Neoplastic, and Ethionine-treated Liver Tissues R. L. Hancock 01 May 1971-Cancer Research 13 Citations	It is proposed that alterations of minor nucleotides in the maturation of tRNA could be basic to the carcinogenic process.
Journal Article•DOI RNAi-mediated knockdown of MCM7 gene on CML cells and its therapeutic potential for leukemia. Liang Tian, Juan Liu, Guohua Xia, Baoan Chen - Show less +3 more 05 Jan 2017-Medical Oncology 13 Citations	It is indicated that RNAi application for targeting functional carcinogenic molecules, tumor resistance to chemotherapy and radiotherapy is required in cancer treatment.