Is RNA genome alone still infectious?
Answers from top 10 papers
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Papers (10) | Insight |
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We demonstrated that the naked genome RNAs are slightly infectious, if the inoculation is done at very high concentrations, or if it is preceded by an additional inoculation with the RNAs 1 and 2 (encoding subunits for the viral RNA polymerase). | |
38 Citations | Our results with West Nile, Dengue, and La Crosse viruses demonstrate that DNA forms of the viral RNA genome are generated in mosquito cells; however, not the entire viral genome, but patches of viral RNA in DNA forms can be detected 24h post infection. |
10 Citations | RNA viruses may be particularly capable of contributing to the increasing biomedical problem of infectious disease emergence. |
63 Citations | In addition, we show that the 5′ nontranslated region of the genome most likely does not contain cis-acting RNA structures required for RNA packaging into infectious virions. |
75 Citations | These findings suggest that RNA viruses may utilize oxidative stress induced during infection to help temporally control genome RNA capping and genome replication. |
14 Citations | RNA 2 is therefore neither a subgenomic nor a, satellite RNA, but rather an essential part of the viral genome. |
We conclude that the genetic content of nonenveloped RNA viruses is variable, not just by genome mutation, but also in the diversity of RNA transcripts that are packaged. | |
It is demonstrated that positive-strand RNA virus genome strategies are not necessarily monophyletic characters and could, in some cases, evolve convergently. | |
Further, we concluded and supported experimentally that the viral RNA is subjected to cytosolic degradation strongly limiting the probability of a successful genome import into the nucleus. | |
Also, unlike DNA‐based vaccines, there is little danger of incorporation of RNA sequences into the host genome. |