Is the neuron theory doctrine still a useful model for studying CNS function today?
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01 Jan 2010 13 Citations | The bona fide changes in neuronal connections that occur in vivo may or may not be identical to LTP as it is presently studied in the laboratory, but this does not diminish its utility as a cellular model system for studying lasting neuronal change in the mammalian CNS. |
| Thus, this methodology is useful for studying protein localization and function throughout CNS development with little or no disruption of neuronal function. | |
19 Citations | These results are very useful for building-up a large-scale neuron network with different biological functional roles and cognitive activities, especially in establishing some specific neuron network models of neurological diseases. |
| There are several trends extending or renewing Sherrington’s “neuron doctrine.” Freeman has proposed a “neo-Sherringtonian view” of integrative brain function, whereas Barlow and Mountcastle have proposed modern views on the neuron doctrine (see Chap. | |
18 Citations | Investigating these disorders could be facilitated if a readily available human cell model were to reflect central nervous system (CNS) function. |
18 Oct 2008 16 Citations | It is reasoned that the traditional model of neuron is very restrictive. |
| Revisiting the Neuron Doctrine suggests that future research outside its limits may lead to new insights into the unique capabilities of the human brain. | |
138 Citations | It settled the then-current debate between the "Reticular Theory" versus "Neuron Doctrine" ideas about the fundamental nature of the nervous system in mammals in favor of the latter, and it changed forever the way in which subsequent generations have viewed the organization of the central nervous system. |
| We conclude that the evidence fails to support the radical neuron doctrine. | |
| It is believed that the introduction of the new neuron model will pave a new way in ANN studies. | |
| We use it to demonstrate how early functional neuronal connectivity and behavior may in life result from simple developmental “rules,” which lay out a scaffold for the vertebrate CNS without specific neuron-to-neuron recognition. | |
| We argue that the neuron doctrine appears to be both substantive and uncontroversial only as a result of a conflation of these two versions. |
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