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If control of DNA function is exerted through firmly bound amino-acids and peptides, then DNA from bacteria grown under these two sets of conditions should contain different amounts of amino-acids.
These data describe a probable cellular-DNA binding platform that involves at least 5 amino acids, in the following order of importance: 124>128>(98, 125)>123.
In the present work we demonstrate that linker amino acids promote engagement with DNA.
It is concluded that amino acids have an effect on DNA synthesis and that the use of dialyzed serum and the manipulation of amino acid concentrations of medium can produce synchronized DNA synthesis and cell division.
The amino acids found complexed to DNA in intact cells by chromate were thought to originate from reactions of free amino acids or small peptides with the DNA rather than being proteolytic products derived from larger proteins that were cross-linked to the DNA.
Thus, we predict that appropriate amino acids at these positions may form contacts with DNA.
Amino acids likely provide building blocks for nucleic acids, peptidoglycan, and protein synthesis.
The results show that a supply of amino acids is essential for nucleic acid synthesis in E. coli.
In conclusion, the majority of amino acid-base interactions observed follow general principles that apply across all protein-DNA complexes, although there are individual exceptions.

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