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Miliary tuberculosis, which is often present, is probably a result rather than the cause.
Adrenal glands may be directly or indirectly affected by tuberculosis.
This may contribute to the long incubation periods observed in prion diseases.
Journal ArticleDOI
Jungsu Kim, David M. Holtzman 
12 Nov 2010-Science
23 Citations
This has implications for a pathogenic mechanism reminiscent of prion transmission.
This model is consistent with the occurrence of rare, sporadic forms of prion diseases.

Related Questions

What causes pulmonary tubercolusis?4 answersPulmonary tuberculosis, caused by Mycobacterium tuberculosis, can be influenced by various factors. Smoking behavior is a significant risk factor for TB infection, as it weakens the lungs and increases susceptibility to tuberculosis germs. Additionally, the home environment plays a crucial role in the transmission of pulmonary TB, with factors like ventilation, occupancy density, and lighting impacting the disease's incidence. Furthermore, relapses of pulmonary TB can occur due to inadequate treatment, immunodeficiency, comorbidities, and other medical factors, as well as organizational challenges like poor follow-up and lack of active case detection. Social causes such as poor living conditions, low sanitary culture, migration, and low social support also contribute to the occurrence of pulmonary tuberculosis. These multifaceted factors collectively contribute to the causes of pulmonary tuberculosis.
Are prion normal in our body ?5 answersPrions are not normal in our body. Prions are infectious proteins that have been implicated in several neurodegenerative diseases in animals and humans. The normal cellular prion protein (PrPc) is present in neural and non-neural tissues, including skeletal muscle. In prion diseases, PrPc is converted into a disease-associated isoform called PrP(Sc). PrP(Sc) is resistant to proteinase K treatment and forms aggregates in the brain, leading to the characteristic pathology of prion diseases. While PrPc is normally soluble and sensitive to proteinase K, PrP(Sc) is insoluble and resistant to proteinase K. The accumulation of PrP(Sc) is typically limited to the brain, except in the case of variant Creutzfeldt-Jakob disease where it can also be found in lymphoid tissues. Therefore, the presence of PrP(Sc) in certain tissues is indicative of prion disease, rather than a normal physiological state.
What is the etiology of tuberculosis?5 answersTuberculosis (TB) is caused by the microorganism Mycobacterium tuberculosis, also known as Koch's bacillus (BAAR).
What is the role of genetics in tuberculosis?5 answersGenetics plays a significant role in tuberculosis (TB) susceptibility and disease progression. Studies have identified genetic polymorphisms in various genes involved in immune response, such as STAT3, CCL-2/MCP-1, NRAMP-1/SLC11A1, IL-8, TLR, NOD-2, and IFN-gamma, that are associated with TB susceptibility. These genetic variations can alter immune function and contribute to the development of TB. Additionally, genetic factors have been implicated in the transition from TB infection to active disease, with pathways related to T and B cell signaling, T helper cell differentiation, and MTB-human co-evolution playing a role. However, the exact genes and mechanisms involved in TB susceptibility and disease progression are still being investigated. Further research is needed to understand the complex genetic interactions and networks that determine the outcome of TB infection.
What are the risk factors for HIV and TB coinfection?2 answersTB/HIV coinfection has several risk factors. These include disruption of cytokine balances, impairment of immune cell functionality, and an increase in HIV viral loads caused by Mycobacterium tuberculosis (Mtb) infection. In resource-limited countries, patients with TB/HIV coinfection face economic, sociocultural, and behavioral barriers to effective treatment, such as low treatment literacy, poverty, and gender inequality. Factors associated with TB/HIV coinfection include marital status, education status, weight less than 50kg, CD4 level < 200cells/mm3, and being at WHO clinical stage III. HIV is the strongest risk factor for the development of TB disease, and TB is the leading cause of death in people living with HIV. In Pakistani population, risk factors for TB in HIV patients include male gender, advanced stage HIV, younger age groups, no INH prophylaxis, and a positive family history of TB.
Does masturbation causes tuberculosis?4 answers

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