Subthreshold symptoms as predictors of depression and anxiety disorders
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8 Citations | Based on the literature the presence of subthreshold depression and anxiety is associated with more medical comorbidity, more workdays lost, greater use of services for medical and mental health problems and increased suicide risk. |
| Subthreshold-depression and subthreshold-anxiety are associated with an increased burden of disease and suicide risk. | |
| Subthreshold depressive symptoms mediated the associations between pain and depression recurrence. Pain, not chronic disease, increases the likelihood of depression recurrence, largely through its association with aggravated subthreshold depressive symptoms. | |
| A history and subthreshold symptoms independently predicted the subsequent occurrence of depressive or anxiety disorder. | |
| confirm previous reports that subthreshold depression and anxiety impact cognitive and brain functioning and suggest that the interaction of depression and anxiety results in distinct cognitive and brain changes. | |
45 Citations | Subthreshold anxiety disorder is relatively prevalent and at three-year follow-up a substantial part of respondents experienced persistent symptoms or had progressed into an anxiety disorder. |
| The persistence of subthreshold-level depression and anxiety from early to mid adulthood also suggests the importance of characterizing the continuum of expression of depression and anxiety rather than adhering to strict diagnostic thresholds. | |
36 Citations | Since subthreshold depression can progress to depression, clinicians should routinely screen for depressive symptoms. |
Open access•Journal Article 43 Citations | Our findings also suggest that subthreshold depressive symptoms in anxious youth relate to the severity of symptomatology and family dysfunction reported, but subthreshold anxiety symptoms in depressed youth do not. |
81 Citations | The presence of subthreshold anxiety disorders, but not subthreshold depression, is influenced by age, gender, and previous professional level. |
Related Questions
What is depression and some common symptoms that people might experience?5 answersDepression is a mood disorder characterized by persistent feelings of sadness, hopelessness, and loss of interest in activities. Common symptoms of depression include changes in appetite, sleep disturbances, feelings of worthlessness, guilt, and thoughts of self-harm or suicide. Additionally, symptoms can vary in severity, with mild depression manifesting as low energy and lack of motivation, moderate depression involving persistent sadness and difficulty concentrating, and severe depression leading to complete loss of interest in activities and suicidal thoughts. Depression can affect individuals differently based on gender and age, with men, women, and children experiencing distinct symptoms such as irritability, withdrawal from social engagements, and decline in school performance, respectively. It is a prevalent mental health condition affecting millions worldwide and is a significant contributor to the global burden of diseases.
How does the comorbidity of depression and anxiety affect well-being?5 answersThe comorbidity of depression and anxiety significantly impacts well-being across different populations. Research on cancer patientsreveals that those with both depression and anxiety experience the lowest health-related quality of life (HRQoL) compared to other groups. In college students, depression has a notable effect on emotional clarity and psychological well-being, while anxiety does not directly impact emotional clarity. Adolescentsundergoing a transdiagnostic cognitive-behavioral therapy program show improvements in school adjustment and well-being. Longitudinal studiesdemonstrate that persistent comorbid anxiety and depression in childhood and adolescence lead to multiple adverse outcomes in young adulthood. Moreover, in haematological cancer patients, increased depression is associated with decreased quality of life, cognitive functioning, and increased fatigue, while heightened anxiety is linked to decreased social and emotional functioning and increased financial difficulties.
What are the most prevalent comorbidities among individuals diagnosed with depression and anxiety disorders?5 answersThe most prevalent comorbidities among individuals diagnosed with depression and anxiety disorders include generalized anxiety disorder (GAD), suicidality, panic disorders, alcohol use disorders, and substance use disorders (SUDs). Studies indicate high rates of anxiety and depression in individuals with diabetes, with prevalence ranging from 3.9% to 44% for anxiety disorder and 8% to 44% for depression. Additionally, individuals with comorbid GAD and major depressive disorder (MDD) exhibit a significantly higher burden of social adjustment problems, additional psychiatric disorders, and poorer mental health quality of life compared to those with single disorders. Furthermore, individuals attending residential substance use treatment centers commonly present with anxiety disorders, depression, posttraumatic stress disorder (PTSD), obsessive-compulsive disorders (OCD), and eating disorders as comorbidities.
What is the relationship between genetic vulnerability and subthreshold depression?5 answersGenetic vulnerability is related to subthreshold depression, as individuals with a higher genetic risk for depressive symptoms are more likely to exhibit subthreshold depression. This relationship is influenced by various environmental factors. For example, the serotonin receptor 2A (HTR2A) gene moderates the association between childhood maternal nurturance and adulthood depressive symptoms, with individuals carrying certain genotypes being less likely to experience depressive symptoms when exposed to high maternal nurturance. Additionally, the tryptophan hydroxylase 1 (TPH1) gene may play a role in the development of depression by influencing an individual's sensitivity to depressogenic environmental influences. These findings suggest that genetic vulnerability interacts with environmental factors to contribute to the development of subthreshold depression.
How does the concept of "subthreshold depression" relate to the debate over the necessary number of symptoms ?4 answersThe concept of "subthreshold depression" refers to depressive conditions that do not meet the full symptomatic or duration criteria for a major depressive disorder (MDD). There is a debate over the necessary number of symptoms required to diagnose subthreshold depression. Some studies propose that two or more simultaneous symptoms of depression, present for most or all of the time, at least 2 weeks in duration, associated with evidence of social dysfunction, can be considered as subthreshold depression. However, there is wide heterogeneity in the definition and diagnostic criteria of subthreshold depression, with variations in the number of symptoms and duration required. The lack of well-defined diagnostic criteria for subthreshold depression has limited research on this disorder. It is important to reexamine the thresholds for depressive disorders and distinguish them from ordinary feelings of sadness.
Is there a link between anxiety and depression?5 answersThere is a strong link between anxiety and depression. Anxiety and depressive disorders are common mental disorders that often co-occur and have a high incidence worldwide. Research has shown that anxiety symptoms predict later depressive symptoms, and vice versa. Additionally, anxiety disorders can be prodromes for depressive disorders, and vice versa. The relationship between anxiety and depression is complex and can manifest in various ways. For example, anxiety can complicate depression, and depression can be a complication of anxiety. The nature of their relationship depends on the specific presentations of anxiety and depression in individual patients. It is important to consider the modalities of presentation and use clinical judgment when selecting treatment for patients with coexisting anxiety and depression.