Was Spanish flu an RNA virus?
Answers from top 10 papers
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| Papers (10) | Insight |
|---|---|
100 Citations | Thus, the Spanish Flu virus resembles avian influenza A viruses in its ability to recruit Crk/CrkL to modulate host cell signaling. |
19 Citations | This was later supported by the finding that MVV is an RNA virus. |
20 Citations | s/Significance These findings suggested that influenza A virus may acquire an RNA polymerase adapted to different body temperatures of the host by reassortment of the RNA polymerase genes. |
231 Citations | Influenza virus is a negative strand RNA virus and is one of the rare RNA viruses to replicate in the nucleus. |
34 Citations | Along with previous reports, our data propose that influenza A virus uses a redundant and plastic network of RNA-RNA and potentially RNA-nucleoprotein interactions to coordinately incorporate its segmented genome into virions. |
| Influenza virus is thus unique among nononcogenic RNA viruses in synthesizing its mRNA in the nucleus. | |
35 Citations | Taken together, these data suggest that HA and the viral RNA polymerase complex are critical determinants of Spanish influenza pathogenesis, but only HA, and not the viral RNA polymerase complex and NP, is responsible for extreme host responses observed in mice infected with the 1918 influenza virus. |
| (1) identifies virus-encoded, short RNAs (svRNA) as a component of the influenza A viral replicase and an essential prerequisite for viral RNA synthesis. | |
26 Citations | This sedimentation pattern corresponds closely to that of incomplete influenza virus RNA. |
| Although a great deal of evidence indicates that the 1918 A(H1N1) influenza virus unlikely originated in and spread from Spain, the 1918-1919 influenza pandemic will always be known as the Spanish flu. |