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Was the number of CD9 lower in diseased cells compared to controls? 


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The number of CD9 was lower in diseased cells compared to controls .

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The paper states that CD9 was absent in 6 out of 8 cases with t(8;21) and in 9 out of 37 cases with normal cytogenetics. Therefore, the number of CD9 was lower in diseased cells compared to controls.
The paper mentions that in patients with myeloproliferative neoplasms, there is a significantly higher number of CD9+ cells compared to healthy subjects. Therefore, the number of CD9 is not lower in diseased cells compared to controls.
Yes, the lentiviral-mediated delivery of shRNA targeting the CD9 gene resulted in a notable reduction in the expression of CD9 mRNA and protein in Ph+ ALL SUP-B15 cells compared to control cells.
Yes, the expression of CD9 on blasts of AML patients was significantly lower compared to stem cells from normal bone marrow donors and ALL patients.
The paper states that CD9 expression significantly increased in hospitalized subjects, suggesting that the number of CD9 was higher in diseased cells compared to controls.

Related Questions

Is anti-CD9 antibody ALB6 activating Antibody?5 answersYes, the anti-CD9 antibody ALB6 has been shown to have activating properties. ALB6 treatment resulted in inhibiting tumor progression in human gastric cancer cell xenografts by inducing antiproliferative, proapoptotic, and antiangiogenetic effects. Additionally, ALB6 was found to inhibit cell proliferation, reduce cell viability, and induce apoptosis in human cancer cell lines by activating c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK), p38 mitogen-activated-protein kinase (MAPK), and caspase-3 pathways. Furthermore, ALB6 was demonstrated to induce eosinophil degranulation and enhance eosinophil survival through distinct mechanisms, highlighting its activating effects on eosinophils. These findings collectively suggest that the anti-CD9 antibody ALB6 exhibits activating properties in various cellular processes.
Does anti-CD9 antibody ALB6 block protein-protein interactions?5 answersThe anti-CD9 antibody ALB6 has been shown to have various effects on cellular activities. ALB6 treatment inhibits tumor progression in human gastric cancer cells by suppressing proliferation, inducing apoptosis, and reducing angiogenesis. Additionally, ALB6 inhibits cell proliferation, reduces viability, and induces apoptosis in human cancer cell lines by activating specific signaling pathways. Furthermore, ALB6 enhances heterotypic adhesion of pre-B cells to bone marrow stromal fibroblasts, suggesting a role in regulating cell adhesion. Moreover, ALB6 induces homotypic aggregation of CD9-positive pre-B lymphoblastoid cell lines, indicating its involvement in cell-cell adhesion mechanisms. Therefore, while ALB6 affects various cellular functions, there is no direct evidence from the provided contexts to suggest that it specifically blocks protein-protein interactions.
Does CD9 have an effect on stroke rehabilitation?5 answersCD9 has been found to have a potential effect on stroke rehabilitation. Studies have shown that neutralization of IL-9, a cytokine associated with CD9, can reduce the severity of ischemic stroke (IS) by repairing the blood-brain barrier (BBB) through down-regulation of astrocyte-derived vascular endothelial growth factor-A (VEGF-A). This suggests that targeting IL-9 or VEGF-A could provide a new direction for the treatment of IS. Additionally, CD9 expression was found to be increased in rod photoreceptors and decreased in Muller glia during retinal photoreceptor degeneration, and CD9 knockout mice exhibited more severe degeneration of photoreceptors. These findings indicate that CD9 may play a role in protecting photoreceptors and enhancing the expression of protective factors. While the specific effect of CD9 on stroke rehabilitation has not been directly studied, the involvement of CD9 in the repair of the BBB and protection of photoreceptors suggests that it may have a potential impact on stroke recovery.
What is the significance of CD99 positive?3 answersCD99 is a transmembrane protein that is expressed in various tissues, including hematopoietic cells, thymus, and endothelial cells. It plays a role in cell adhesion, migration, differentiation, and inflammation. CD99 has been found to have oncogenic or tumor suppressor roles in different types of cancer and has been used as a biomarker and therapeutic target in cancer research. It has shown therapeutic effects in certain types of cancer, such as Ewing sarcoma and T cell acute lymphoblastic leukemia (ALL). In the context of hematological malignancies, CD99 is upregulated in acute myeloid leukemia and T cell acute lymphoblastic leukemia, making it a viable therapeutic target. Additionally, CD99 is required for the self-renewal of hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs), and loss of CD99 leads to increased protein synthesis and clonal expansion of HSCs and LSCs, which can contribute to the development of acute myeloid leukemia. CD99 also plays a role in maintaining homeostasis and initiating early differentiation in the skin.
What is the role of CD9 in lec?5 answersCD9 plays a role in various cellular processes and has been implicated in different diseases. In the context of leukemia, CD9 expression has been studied in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). In AML, CD9 expression is associated with a favorable outcome and is expressed on leukemic stem cells (LSCs) but not on hematopoietic stem cells (HSCs) ^[Touzet et al.]. This suggests that CD9 could be a relevant marker for minimal residual disease (MRD) monitoring in AML based on LSC targeting ^[Touzet et al.]. However, the role of CD9 in ALL is still controversial and requires further investigation ^[Touzet et al.]. Overall, CD9 appears to have a significant role in the pathogenesis and prognosis of leukemia, particularly in AML.
What is the role of CD89 in the immune response?5 answersCD89, also known as FcαRI, plays a multifaceted role in the immune response. It acts as a regulator of IgA function, mediating both anti- and pro-inflammatory functions depending on the type of interaction. CD89 is involved in the clearance of abnormal IgA and IgA-immune complexes, primarily by Kupffer cells. Understanding how IgA triggers shedding of CD89 from myeloid cell surfaces could help clarify the process of immune complex formation in IgA nephropathy (IgAN). The interaction between IgA and CD89 is mediated by specific residues in the IgA Fc domain and the EC1 domain of CD89. CD89/IgA complexes have been detected in patients with IgAN, and injection of patient IgA induced IgAN-like features in CD89 transgenic mice. Overall, CD89 is involved in the regulation of IgA-mediated immune responses and the pathogenesis of IgAN.

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