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What are the characteristics of hydrodynamic pressure controlled drug delivery systems?

Targeted drug delivery

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Open access•Journal Article•DOI Modular Hydrogels for Drug Delivery Susana Simões, Ana Figueiras, Francisco Veiga - Show less +2 more 28 Apr 2012-Journal of Biomaterials and Nanobiotechnology 71 Citations	These novel systems exhibit a range of several peculiar properties which make them attractive as controlled drug release formulations.
Journal Article•DOI Evaluation and comparison of dissolution data derived from different modified release dosage forms: an alternative method. Viness Pillay, Reza Fassihi - Show less +1 more 30 Oct 1998-Journal of Controlled Release 217 Citations	For the osmotic pump the required osmotic pressure threshold necessary for constant rate drug delivery appears to have reached independent of the hydrodynamic conditions.
Book Chapter•DOI Responsive biopolymer-based microgels/nanogels for drug delivery applications Selin Sagbas Suner, Mehtap Sahiner, Sultan B. Sengel, Daniel J. Rees, Wayne F. Reed, Nurettin Sahiner - Show less +5 more 01 Jan 2018 29 Citations	Therefore, the control of these parameters is the most imperative cue to design long-term sustained drug delivery systems.
Book•DOI Directed Drug Delivery Ronald T. Borchardt, Arnold J. Repta, Valentino J. Stella - Show less +2 more 01 Jan 1985 399 Citations	The predictive potential of the pharmacokinetic-pharmacodynamic models should prove useful in evaluating pharmaceutical formulations with controlled drug delivery.
Open access•Journal Article•DOI Development and design of double-layer co-injection moulded soy protein based drug delivery devices Cláudia M. Vaz, P. F. N. M. van Doeveren, Rui L. Reis, António M. Cunha - Show less +3 more 01 Sep 2003-Polymer 41 Citations	The preliminary results confirmed the potential of these systems to achieve a controlled drug delivery.

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What factors influence hydrodynamics pattern?4 answersHydrodynamics patterns are influenced by various factors. One important factor is the modification of physical properties of a solution, such as density or viscosity, which can trigger convective flows. Another factor is the presence of inserts in microchannels, which can significantly change the formation velocity range and characteristic sizes of flow patterns. Additionally, the change in hydrodynamic distribution, particularly due to factors like water level and thermal density currents, plays a crucial role in the formation of phytoplankton blooms and algae in bays and reservoirs. The geometry, cavity gap, and fluid volume of rotor-stator vortex reactors also affect the turbulent aggregation, hydrodynamics, and flow patterns. Furthermore, the presence of attractive particles in suspensions can lead to complex, anisotropic microstructures and flow instabilities, with hydrodynamic coupling between the particles and confining boundaries influencing the formation of log-rolling flocs.

What are the significance of model membrane systemfor drug delivery?4 answersModel membrane systems are of great significance for drug delivery. They provide a platform for studying interactions between drug molecules and cell membranes, which is crucial for understanding the behavior and effectiveness of drugs in the body. These systems allow researchers to investigate the permeability and retention of lipophilic drugs, which are often challenging to deliver effectively. Additionally, model membrane systems can be used to simulate and study membrane fusion, which plays a vital role in drug delivery and the function of intracellular substances. Furthermore, the development of tunable drug delivery systems relies on the understanding and control of drug release mechanisms, which can be achieved through the use of model membrane systems. Overall, model membrane systems provide valuable insights into drug-membrane interactions and can aid in the design and optimization of drug delivery systems.

What is hydrodynamic system?3 answersA hydrodynamic system is a machine that utilizes the flow of a working medium, such as water or hydraulic fluid, to generate power or produce a braking torque. It typically consists of blade wheels, such as rotors and stators, arranged concentrically to form a toroidal working chamber. The system also includes various components such as pumps, valves, heat exchangers, and reservoirs, which control the flow of the working medium. The working medium is circulated through a line system, and its flow can be controlled by pressure control valves or electro-hydraulic systems. The generated power can be used to produce electrical power through a generator or to provide braking torque in a hydrodynamic retarder.

What are the advantages and disadvantages of controlled drug release systems?5 answersControlled drug release systems offer several advantages over conventional drug delivery methods. These systems can enhance treatment efficacy and improve patient compliance by maintaining consistent drug concentrations in the blood, optimizing therapeutic effects, and reducing side effects. They also provide sustained release of drugs, allowing for less frequent dosing and better dosing patterns. Additionally, controlled drug release systems can protect therapeutic proteins and peptides against degradation, ensuring their effectiveness. However, these systems may face challenges such as changes in drug performance due to physiological factors like patient age or food intake. Furthermore, the development of controlled drug delivery systems requires careful design considerations and may involve complex techniques. Safety concerns and limitations in triggering mechanisms have also hindered the translation of some techniques from in vitro to in vivo applications.

What are the disadvantages of using thermo-responsive hydrogel controlled drug delivery ?3 answersThermo-responsive hydrogel controlled drug delivery has several disadvantages. One disadvantage is the need for additional crosslinking agents, such as hydrogels with dual pH and thermo-responsiveness, which can make it difficult to manage the structure of these hydrogels. Another disadvantage is the potential for a burst release of the drug, which can lead to ineffective treatment and potential side effects. Additionally, the strength of temperature-sensitive hydrogels can be weak, which may limit their ability to effectively control drug release. Furthermore, the drug release rate of thermo-responsive hydrogels can be regulated by temperature and reducing environment, which may not provide precise control over drug release. These disadvantages highlight the challenges and limitations of using thermo-responsive hydrogel controlled drug delivery systems.

How does ph activated drug delivery work?4 answers

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