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What are the epigenetic changes that occur in metabolic syndrome? 


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Epigenetic changes that occur in metabolic syndrome include DNA methylation, histone modifications, chromatin remodeling, and microRNA-mediated processes . These changes can be influenced by genetic predisposition, environmental factors such as diet and lifestyle, and maternal factors during pregnancy . Epigenetic alterations have been associated with various aspects of metabolic syndrome, including obesity, impaired glucose tolerance/diabetes, dyslipidemia, and a prothrombotic state . These changes can affect gene expression without altering the DNA sequence and can be reversible . Furthermore, epigenetic modifications can occur during the prenatal period and throughout the lifespan, potentially leading to transgenerational transmission of an epigenetic state . Understanding these epigenetic mechanisms is crucial for developing strategies for early detection and prevention of metabolic syndrome .

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The epigenetic changes in metabolic syndrome include DNA methylation and histone covalent modifications, which can influence gene expression without altering the DNA sequence.
The paper discusses that epigenetic alterations induced by suboptimal maternal nutrition/endocrine factors include DNA methylation, histone modifications, chromatin remodeling, and regulatory feedback by microRNAs, all of which have the ability to modulate gene expression and promote the metabolic syndrome phenotype.
Open accessJournal ArticleDOI
Caryn Carson, Heather A. Lawson 
31 Citations
The paper discusses recent breakthroughs in epigenetic markers in studies of obesity, Type II diabetes, and cardiovascular disease, which are the three major disorders associated with metabolic syndrome. However, it does not specifically mention the epigenetic changes that occur in metabolic syndrome.
The paper discusses both classical epigenetic changes affecting DNA methylation and histone modifications, as well as small RNA-mediated processes, particularly microRNAs, that are associated with the pathophysiology of metabolic syndrome.

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What is the role of epigenetics in the development of cancer?4 answersEpigenetics plays a crucial role in the development of cancer. Mutations or abnormal expression of oncogenes and tumor suppressor genes are known to cause cancer, but recent studies have shown that epigenetic modifications are also key drivers of cancer development and progression. Epigenetic changes, such as DNA methylation and histone modifications, regulate gene expression without altering the primary DNA sequence. These changes can cooperate with genetic alterations to drive the cancer phenotype. The plasticity of cancer cell phenotypes is a result of stochastic changes in the epigenetic landscape, which can be quantitatively mapped onto phenotypic outcomes. Epigenetic dysregulation in the tumor microenvironment is also important, as it affects both cancer cells and non-cancer cells. Understanding the role of epigenetics in cancer development is crucial for the development of epigenetic drugs and the comprehensive treatment of cancer.
How does epigenetic affects metabolic syndrome?5 answersEpigenetic modifications play a crucial role in the development and progression of metabolic syndrome. These modifications can regulate gene expression, chromatin compaction, and DNA repair, thereby impacting the function of adipose tissue (AT) and metabolic pathways involved in obesity and metabolic disorders. The prenatal environment, aging, and lifestyle factors such as diet and physical activity can induce long-lasting epigenetic alterations that influence the risk of metabolic diseases later in life. Epigenetic changes in AT can lead to disturbances in its function, contributing to the onset of obesity and related metabolic disorders. Additionally, dietary factors can significantly affect epigenetic modifications and gene-diet interactions, which are important in the initiation and progression of metabolic syndrome. Understanding the role of epigenetics in metabolic syndrome can provide insights into the underlying mechanisms and potentially lead to the development of targeted therapeutic interventions.
What are the effects of different epigenetic modifications ?5 answersEpigenetic modifications have various effects on gene expression and cellular function. These modifications include DNA methylation, histone modification, and non-coding RNA activity. DNA methylation and histone modification can alter gene expression without changing the DNA sequence. They play a role in aging-related diseases such as osteoporosis. Epigenetic modifications also have implications in infectious diseases, as pathogens can manipulate host cells through epigenetic strategies. Furthermore, epigenetic modifications are involved in the non-targeted effects of ionizing radiation, which can impact normal tissues and contribute to side effects of radiotherapy. The epigenome can be influenced by various factors, including hormones, environment, diet, and exposure to endocrine disrupting chemicals. These modifications can have transgenerational effects, affecting phenotypes in offspring. Overall, epigenetic modifications play a crucial role in gene regulation and have significant implications in various biological processes and diseases.
Are epigenetic modifications reversible with time?5 answersEpigenetic modifications, including DNA methylation, histone methylation, histone acetylation, and RNA methylation, are reversible. While most epigenetic modifications are reversible in nature, they can be stably maintained through the cell cycle. Epigenetic changes are somatically heritable and can be reversed, making them potential targets for therapeutic intervention. The epigenome varies dynamically through reversible modifications conditioned by environmental pressures. Epigenetic processes, including DNA methylation, histone modifications, and non-coding RNAs, are reversible and can be targeted by epidrugs for cancer treatment. Overall, the evidence from these abstracts suggests that epigenetic modifications are reversible and can be targeted for therapeutic purposes.
How dose fatty acid metabolism affect epigenetic?5 answersFatty acid metabolism can affect epigenetic processes. Certain fatty acids, such as n-3 PUFA (EPA and DHA) and MUFA (oleic and palmitoleic acid), have been associated with improved metabolic outcomes and protective effects on chronic diseases. On the other hand, n-6 PUFA, saturated fatty acids (stearic and palmitic), and trans fatty acids (elaidic) have been linked to the development of obesity, type 2 diabetes, pro-inflammatory profile, atherosclerosis, and insulin resistance, along with epigenetic changes. Studies have shown that fatty acids, particularly polyunsaturated fatty acids, can modify the epigenome, including DNA methylation and histone methylation. Additionally, fatty acid metabolism has been found to play a role in cancer, such as glioblastoma and acute myeloid leukemia, with potential therapeutic implications. However, further research is needed to fully understand the specific mechanisms and effects of fatty acid metabolism on epigenetic regulation.
Can histone methylation cause epigenetic changes?9 answers

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