scispace - formally typeset
Search or ask a question

What are the key mechanisms that control mitochondrial dynamics? 


Best insight from top research papers

Mitochondrial dynamics, including fusion and fission, are regulated by a variety of mechanisms. Proteins such as Mitofusin 1 (MFN1), Mitofusin 2 (MFN2), and optic atrophy 1 (OPA1) are involved in mitochondrial fusion, while mitochondrial fission 1 (FIS1) and dynamin-related protein 1 (DRP1) mediate mitochondrial fission . These proteins interact with each other to maintain mitochondrial quality control and ensure cellular metabolic homeostasis . Additionally, other proteins such as guanosine triphosphatases (GTPases) and mitochondrial receptors, including Fis1, Mff, and MIEFs, play crucial roles in regulating mitochondrial dynamics . Post-translational proteolysis and turnover are also important mechanisms for regulating the function of these proteins . The endoplasmic reticulum (ER), actin cytoskeleton, and membrane phospholipids have been identified as additional regulators of mitochondrial dynamics . Overall, the coordination of these mechanisms is essential for maintaining the balance between mitochondrial fusion and fission and ensuring proper mitochondrial network organization .

Answers from top 4 papers

More filters
Papers (4)Insight
The key mechanisms that control mitochondrial dynamics include mitochondrial fusion proteins (Mfn1/2 and OPA1) and mitochondrial fission proteins (Drp1). These proteins regulate the shape, size, and distribution of mitochondria in cells.
Open accessPosted ContentDOI
Sumaira Ali, Gavin P. McStay 
27 Nov 2017
3 Citations
The key mechanisms that control mitochondrial dynamics are post-translational proteolysis and protein turnover. These mechanisms regulate the expression and stability of mitochondrial dynamics proteins.
The paper discusses the potential molecular mechanisms underlying mitochondrial fusion and fission, including the coordinating roles of mitochondria-shaping proteins, the involvement of the endoplasmic reticulum (ER), the actin cytoskeleton, and membrane phospholipids in the regulation of mitochondrial dynamics.
The paper discusses the key mechanisms of mitochondrial dynamics, including fusion proteins (MFN1, MFN2, and OPA1) and fission mediators (FIS1 and DRP1), which interact to maintain mitochondrial quality control.

Related Questions

What are the specific molecular mechanisms through which inflammation affects mitochondrial function?5 answersInflammation impacts mitochondrial function through various molecular mechanisms. Mitochondrial constituents, such as mtDNA, can act as damage-associated molecular patterns (DAMPs), triggering inflammatory responses when released into the cytosol or extracellular space. This release can activate pathways leading to the expression of pro-inflammatory cytokines and interferons, exacerbating neuroinflammation in neurodegenerative diseases. Furthermore, in the presence of inflammatory stimuli, mitochondria generate reactive oxygen species (ROS) that contribute to mitochondrial damage and oxidative stress, affecting mitochondrial function and redox signaling within cells. Inflammatory environments can also disrupt the mitochondrial tricarboxylic acid (TCA) cycle, leading to decreased enzyme levels and altered mitochondrial membrane potential, which can be reversed by anti-inflammatory treatments like metformin.
What are the Metabolites that effect Mitochondrial Dynamics?4 answersMetabolites play a crucial role in influencing mitochondrial dynamics. Studies have shown that metabolites like pyruvate can impact mitochondrial function by affecting the proliferation of cells with respiratory chain deficiencies. Additionally, the transition from fasting to feeding has been linked to changes in mitochondrial dynamics, including reduced mitochondria-endoplasmic reticulum interactions, induction of mitochondrial fission, and decreased mitochondrial cristae density in human peripheral blood mononuclear cells (PBMCs). Furthermore, mitochondrial dynamics have been associated with tumor progression, where the mitochondrial fusion protein MFN1 has been identified as a key regulator. MFN1 not only influences mitochondrial dynamics but also modulates glucose metabolic reprogramming, shifting cells from aerobic glycolysis to oxidative phosphorylation, impacting hepatocellular carcinoma (HCC) metastasis.
How is melatonin related to mitochondrial dynamics?4 answersMelatonin is closely related to mitochondrial dynamics. It has been shown to have beneficial effects on mitochondrial quality control in various contexts, including ischemia/reperfusion (I/R) injury in the heart. Melatonin treatment has been associated with upregulation of mitochondrial fusion, inhibition of fission, and changes in mitophagy pathways. Additionally, melatonin has been found to stimulate intercellular transfer of mitochondria between damaged cells. In human periodontal cells, melatonin treatment promotes osteogenesis and enhances mitochondrial functions by upregulating the translocase of the outer mitochondrial membrane 20 (TOM20). Melatonin has also been shown to preserve mitochondrial dynamics, promote mitochondrial fusion, and enhance mitochondrial transfer through tunneling nanotubes in cells exposed to oxygen/glucose deprivation followed by reoxygenation. Furthermore, melatonin modulates mitochondrial physiology and energy metabolism in pancreatic stellate cells, affecting pathways related to cellular proliferation and energetic metabolism. Overall, melatonin plays a significant role in regulating mitochondrial dynamics and function in various cellular contexts.
What are the mechanisms that regulate the dynamic nature of cells?5 answersCells regulate their dynamic nature through various mechanisms. They establish interactions with their surrounding microenvironment through integrin receptors, which bind to extracellular matrix proteins and provide vital cues for the cell. Cells also use exploratory actin-based protrusions and contractions to actively sample their environment and probe its chemical and mechanical properties. Excitable signal networks play a role in processing chemical or mechanical signals to steer dynamic cell behavior, such as migration and tissue morphogenesis. Additionally, mathematical analysis and computer simulation have become valuable tools for evaluating hypotheses and mechanisms in cell biology, allowing for quantitative predictions and further experimental exploration. The dynamic regulation of cellular proliferation and differentiation is crucial for tissue and organ development, involving stochastic fate assignment, cell division, feedback control, and cellular transition states.
How is the mitochondrial membrane potential regulated?5 answersThe mitochondrial membrane potential (ΔΨm) is regulated through various mechanisms. One important factor is the level of E-cadherin mediated intercellular adhesion, which correlates with the spatial distribution of ΔΨm in cancer cells in the tumor microenvironment (TME). Additionally, the electrochemical gradient that powers mitochondrial function, ΔΨm, is a core regulator of the mitochondrial unfolded protein response (UPRmt). Mitochondrial Cl− channels, including inactivating ClV (hClV) and non-inactivating ClV (dClV), play a crucial role in maintaining ΔΨm and preserving mitochondrial integrity and function. The association of mitochondria with vimentin intermediate filaments (VIFs) also increases their membrane potential, indicating the importance of their close association for mitochondrial activity. Furthermore, the allosteric ATP-inhibition of cytochrome c oxidase (CcO) helps regulate ΔΨm in isolated mitochondria, keeping it at low values in living cells and tissues.
What are the mechanisms underlying the metabolic reprogramming of mitochondria in the brain?5 answersThe metabolic reprogramming of mitochondria in the brain involves several mechanisms. One mechanism is the activation of the succinate-dependent oxidation pathway, which allows for energy synthesis in conditions of oxygen deficiency and the formation of immediate and long-term adaptation to hypoxia. Another mechanism is the preference for glycolysis over oxidative metabolism in neurons, leading to a Warburg-like effect. Additionally, the ATP-dependent AAA proteases in the inner membrane of mitochondria play a central role in regulating mitochondrial adaptations to stress and altered metabolic cues. Furthermore, the interaction between the F-ATP synthase inhibitory factor 1 (IF1) and the p53-CyPD complex promotes the opening of the mitochondrial permeability transition pore (PTP), suggesting that IF1 may participate in metabolic plasticity by modulating PTP activity. These mechanisms contribute to the metabolic reprogramming of mitochondria in the brain.

See what other people are reading

How does Albizia Lebbeck affect the development and progression of cervical cancer?
5 answers
Albizia lebbeck, a plant with significant medicinal properties, has shown promising effects on cervical cancer. The ethanolic extract of A. lebbeck pods demonstrated potent antitumor activity against Ehrlich ascites carcinoma in mice and cytotoxic effects on cervical cancer cell lines in vitro. Additionally, the induction of callus from Albizia seeds led to an increase in compounds beneficial for cancer treatment. A comprehensive review highlighted the phytochemical richness of A. lebbeck, showcasing its anticancer properties through various mechanisms. Furthermore, the plant's bioactive compounds have demonstrated activities like anticancer, antiallergic, anti-inflammatory, and antioxidant effects, all of which could contribute to combating cervical cancer. These findings collectively suggest that Albizia lebbeck holds potential in influencing the development and progression of cervical cancer through its diverse pharmacological attributes.
What are cultural theories about Korean collective trauma due to inter-Korean conflict?
5 answers
Cultural theories on Korean collective trauma resulting from the inter-Korean conflict emphasize the construction of collective identity through trauma narratives. These theories view trauma as a discursive process where shared suffering is given meaning through competing narrative accounts of the events, responsibilities, and actions to be taken. Additionally, the long-term impact of historical trauma on intergroup relations is influenced by how individuals appraise their group's past victimization and perpetration, either as a threat or a challenge. This differential appraisal, shaped by contextual factors and individual differences, affects how group members respond to contemporary intergroup conflict, leading to both adaptive and maladaptive consequences. Such theories highlight the profound influence of collective memories of trauma on individuals and communities, shaping their identities and responses to conflict.
What are the benefits of using a mixed method approach in research?
5 answers
Using a mixed method approach in research offers several benefits. It allows for a comprehensive understanding of a phenomenon by combining quantitative and qualitative data within a single study. This integration of different research methods provides valid answers to research questions and strengthens study conclusions. Mixed methods can offset weaknesses present in singular methodologies, increasing the value of research projects. In the context of Juvenile Justice special education research, the use of mixed methods is crucial for addressing complex questions and understanding the multitude of contextual factors influencing incarcerated youth research. Overall, the application of mixed methods enhances the depth and completeness of research findings by triangulating data from various approaches, making it a valuable methodology across different fields of study.
What the importance of education to ourselves?
5 answers
Education plays a crucial role in personal development and societal progress. It empowers individuals to make informed decisions, distinguish between right and wrong, and contribute meaningfully to society. Self-education, a form of active learning, fosters qualities like self-control, wisdom, and discipline. In the context of modern society's digitization, self-education has gained prominence as a means to acquire new competencies and enhance personal qualities. For individuals with diabetes, education on self-care practices is vital for managing the condition effectively and improving quality of life. Education not only imparts knowledge but also instills a sense of identity, awakening individuals from ignorance and enabling them to recognize their unique talents. Ultimately, education is the cornerstone of personal growth, societal advancement, and individual fulfillment.
What are the mechanism of bna cyp78a9 in rapeseed?
5 answers
The BnaCYP78A9 gene in rapeseed plays a crucial role in regulating silique length and seed weight. It functions as a positive regulator of silique elongation by influencing auxin concentration in developing siliques. The expression of BnaCYP78A9 is higher in long-silique varieties, leading to elongated cells and prolonged silique elongation. Additionally, a CACTA-like transposable element acts as an enhancer, elevating the expression of BnaCYP78A9 and promoting silique elongation. The BnaCYP78A9 gene is involved in seed development, with mutations resulting in shorter siliques, smaller seeds, and increased seed numbers per silique. These findings highlight the importance of BnaCYP78A9 in seed production control and provide valuable insights for rapeseed breeding programs.
Can AI intrusiveness moderate effects of transparency?
5 answers
AI intrusiveness can indeed moderate the effects of transparency. Research has shown that AI transparency can influence employees' trust in AI, with transparency leading to higher challenge appraisals and trust, and lower threat appraisals. Additionally, AI decision-making transparency can impact humans' trust in AI by affecting perceived transparency, perceived effectiveness of AI, and discomfort with AI. This suggests that the level of intrusiveness of AI, in terms of how transparent its decision-making processes are, can significantly influence how users perceive and trust AI systems. Therefore, understanding and managing AI intrusiveness through transparency measures is crucial in fostering trust and acceptance of AI technologies in various domains.
What are the composition of Earth's reservoirs?
5 answers
The Earth's reservoirs consist of various materials and compounds crucial for its evolution. Primordial dense material in the lower mantle, enriched in iron and heat-producing elements, plays a role in mantle dynamics but has a secondary impact on long-term evolution. Magnesium hydrosilicate phases, such as α-Mg_{2}SiO_{5}H_{2} and β-Mg_{2}SiO_{5}H_{2}, stable at extreme pressures, likely hosted Earth's water before core formation. Surface water reservoirs experience microbiological changes due to climate change, with coliform bacteria proliferating significantly in response to higher temperatures, posing challenges for drinking water production. Exchanges of water between Earth's main reservoirs, influenced by the hydrological cycle and human activities, impact global mean sea level rise and Earth's climate evolution. Isotopic data from meteorites reveal variations challenging the concept of a chondritic uniform reservoir, emphasizing the need for a better understanding of Earth-forming reservoirs.
What studies Digital Transformation Drivers Business Model Transformation in manufacturing only??
4 answers
The digital transformation in manufacturing is driven by several key factors that influence business model transformation, as highlighted by various studies. Yannick Mies and J. Piet Hausberg identify four primary drivers: ubiquitous connectivity, functional dematerialization, relational decentralization, and flexible scalability, proposing a conceptual framework of digital business model archetypes for manufacturing firms. This framework is crucial for understanding how digital transformation can catalyze business model innovation (BMI) by leveraging digital technologies to create integrated digital customer interfaces. Eleonora Boffa and Antonio Maffei emphasize the need for a structural rethink in how companies align manufacturing digitalization with the Business Model Innovation process, proposing an enriched Integrated Business Model (IBM) framework to assist practitioners in navigating technological shifts. Similarly, the role of digital transformation in changing manufacturing through cloud computing, data analytics, and the decentralization of supply chains is highlighted, showing its impact on sustainable manufacturing and business operations. Jianjia He's study on the Industrial Internet in China demonstrates the empowering effect of digital technologies on manufacturing enterprises, enhancing digital transformation through digitalization, technology absorption, and innovation integration. The transformation of business models and competitive strategies in the digital economy is further explored, emphasizing the creation of digital business models and the importance of dynamic capabilities in securing competitive advantages. Zhi Qiang Lai, Bifeng Wang, and Xiang He explore how the digital transformation of producer services fosters manufacturing technology innovation, highlighting the intermediary role of industrial productivity, knowledge stock, and the market environment. Yu Chih Lin discusses the digital transformation path for manufacturing enterprises based on IoT and data encryption technology, aiming to enhance market competitiveness. Camila Favoretto et al. identify organizational commitment, value creation, and technology infrastructure as challenges in digital transformation, proposing a conceptual framework to guide management decisions. Lastly, Xingguang Guo and Xin Chen's theoretical model reveals how digital transformation affects innovation in manufacturing enterprises, highlighting the role of e-commerce embeddedness and human capital. These studies collectively provide a comprehensive understanding of the drivers and impacts of digital transformation on business model transformation in the manufacturing sector.
How can formic acid act as a modulator in MOF synthesis?
4 answers
Formic acid acts as a modulator in MOF synthesis by influencing the structure and properties of the resulting MOFs. It can lead to improvements in porosity, morphology, and crystallinity. When used in the synthesis of Zr-based MOFs, formic acid can decelerate the reaction in water-based systems but accelerate it in DMF-based systems, possibly due to the presence of water in formic acid. Additionally, formic acid can compete with ligands to form specific Th-based MOFs, affecting the resulting structures. Furthermore, in the synthesis of bimetallic MIL-101 (Cr, Sn) MOFs, formic acid alters the properties of the MOFs, while acetic acid narrows particle size distribution, enhances surface area, and improves stability. Overall, formic acid's role as a modulator is crucial in tailoring the properties and performance of MOFs during synthesis.
What are some effective strategies for conducting literature review in a research paper?
4 answers
Effective strategies for conducting a literature review in a research paper involve several key steps. Firstly, it is crucial to develop a meaningful research question that addresses gaps in the existing literature, based on clear objectives and hypotheses. Utilizing multiple databases for comprehensive searches and running preliminary searches to refine search terms and guide study design are essential. Employing tools like reference management systems can aid in organizing and formatting references efficiently. Critically analyzing the relationship among different works, identifying gaps, and relating findings to the current study are vital aspects of a literature review. Additionally, incorporating a variety of sources such as books, journal articles, and electronic resources can enrich the review and provide diverse perspectives.
How can formic acid act as a modulator in cluster synthesis?
4 answers
Formic acid (FA) plays a crucial role as a modulator in cluster synthesis by influencing cluster structures and stability. Quantum chemical studies reveal that FA enhances cluster formation with specific nucleating species like dimethylamine (DMA), methylamine (MeNH2), and water (H2O). FA promotes the stabilization of clusters, leading to increased binding energies per molecule and altered hydrogen-bonding networks within the clusters. Additionally, FA can compete with water molecules in the initial stages of aggregation, forming stable nucleation seeds. Through its stabilizing effects and interactions with various nucleating species, FA acts as a key modulator in cluster synthesis, influencing cluster growth, stability, and structure in the formation of new particles.