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What are the key mechanisms that control mitochondrial dynamics? 

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Mitochondrial dynamics, including fusion and fission, are regulated by a variety of mechanisms. Proteins such as Mitofusin 1 (MFN1), Mitofusin 2 (MFN2), and optic atrophy 1 (OPA1) are involved in mitochondrial fusion, while mitochondrial fission 1 (FIS1) and dynamin-related protein 1 (DRP1) mediate mitochondrial fission . These proteins interact with each other to maintain mitochondrial quality control and ensure cellular metabolic homeostasis . Additionally, other proteins such as guanosine triphosphatases (GTPases) and mitochondrial receptors, including Fis1, Mff, and MIEFs, play crucial roles in regulating mitochondrial dynamics . Post-translational proteolysis and turnover are also important mechanisms for regulating the function of these proteins . The endoplasmic reticulum (ER), actin cytoskeleton, and membrane phospholipids have been identified as additional regulators of mitochondrial dynamics . Overall, the coordination of these mechanisms is essential for maintaining the balance between mitochondrial fusion and fission and ensuring proper mitochondrial network organization .

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The key mechanisms that control mitochondrial dynamics include mitochondrial fusion proteins (Mfn1/2 and OPA1) and mitochondrial fission proteins (Drp1). These proteins regulate the shape, size, and distribution of mitochondria in cells.
Open accessPosted ContentDOI
Sumaira Ali, Gavin P. McStay 
27 Nov 2017
3 Citations
The key mechanisms that control mitochondrial dynamics are post-translational proteolysis and protein turnover. These mechanisms regulate the expression and stability of mitochondrial dynamics proteins.
The paper discusses the potential molecular mechanisms underlying mitochondrial fusion and fission, including the coordinating roles of mitochondria-shaping proteins, the involvement of the endoplasmic reticulum (ER), the actin cytoskeleton, and membrane phospholipids in the regulation of mitochondrial dynamics.
The paper discusses the key mechanisms of mitochondrial dynamics, including fusion proteins (MFN1, MFN2, and OPA1) and fission mediators (FIS1 and DRP1), which interact to maintain mitochondrial quality control.

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