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What are the limitations of traditional diagnoses of diabetes? 


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Traditional diagnoses of diabetes have several limitations. Fasting glucose (FG) only detects 70-80% of overt diabetes and is affected by inappropriate blood sampling and intra-individual fluctuations . The oral glucose tolerance test (oGTT) is the most sensitive test but has poor reproducibility . HbA1c analysis, despite standardization, is difficult to interpret and has limited diagnostic value . Its threshold value of ≥6.5% is based on consensus rather than evidence . These traditional diagnostic methods also have pre-analytical and analytical problems, such as falsification of results and interferences . In addition, the diagnostic effort required for these methods is invasive and may lead to over- or underdiagnosis . Therefore, there is a need for fast, easy, and inexpensive diagnostic approaches for diabetes .

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The limitations of traditional diagnoses of diabetes are not mentioned in the provided paper.
The paper discusses limitations of traditional diabetes diagnoses, including problems with fasting glucose, oral glucose tolerance test, and HbA1c measurements.
The paper discusses the limitations of traditional diabetes diagnoses, including problems with fasting glucose, oral glucose tolerance test, and HbA1c.
The limitations of traditional diagnoses of diabetes are not mentioned in the provided paper.

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