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What are the limitations of traditional malaria diagnostic methods? 

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Traditional malaria diagnostic methods have several limitations. Microscopy, which is considered the gold standard, requires trained personnel, is time-consuming, and has low sensitivity at low parasite density . Rapid diagnostic tests (RDTs) also have limitations, including persistent malaria antigen leading to false positive results, hrp2 deletions leading to false negative results, and limited sensitivity with a detection threshold of around 100 parasites/µl blood . Additionally, traditional methods may have low specificity or sensitivity to non-falciparum species, leading to underestimation of their prevalence and severity . Furthermore, microscopy and RDTs have infrastructure and technical challenges in resource-constrained regions, hindering their use in endemic areas . These limitations highlight the need for more sensitive, accurate, and accessible diagnostic methods for malaria detection.

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The limitations of traditional malaria diagnostic methods include low specificity or sensitivity to non-falciparum species, neglecting their prevalence and severity.
The limitations of traditional malaria diagnostic methods include false positive and false negative results, limited sensitivity, and the need for trained microscopists and well-maintained microscopes.
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The limitations of traditional malaria diagnostic methods include low sensitivity at low parasite density, the need for trained personnel, and being expensive and time-consuming.
The limitations of traditional malaria diagnostic methods are not mentioned in the provided paper.

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