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What are the molecular mechanisms underlying the regulation of metastasis in breast cancer by proteomics method? 

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Proteomics methods have shed light on the molecular mechanisms regulating metastasis in breast cancer. Studies have identified key proteins like fibrinogen gamma (FGG) and fibrinogen beta (FGB) linked to pathways involving RAS-MAPK, integrin signaling, and extracellular matrix remodeling, influencing tumor progression and metastasis . Additionally, the tumor microenvironment (TME) plays a crucial role in metastasis regulation, with pathways like Hedgehog, Wnt, Notch, and NF-kB contributing to the complexity of breast TME and promoting aggressive cancer behavior . High-throughput proteomics assays have revealed potential biomarkers like TUBB and VWA5A, showing differential expression in breast cancer subtypes and impacting invasion and migration abilities, highlighting their role in the biological aggressiveness of breast cancer, especially in triple-negative breast cancer (TNBC) .

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Proteomics identified TUBB and VWA5A as potential biomarkers for metastasis in breast cancer. TUBB overexpression and VWA5A underexpression correlated with poor prognosis, affecting invasion and migration.
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Open accessBook ChapterDOI
08 Mar 2023
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Fibrinogen beta and fibrinogen gamma play key roles in breast cancer metastasis by influencing RAS-MAPK, integrin signaling, and extracellular matrix pathways, as identified through integrated proteomic, transcriptomic, and genomic analysis.
Not addressed in the paper.

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