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What are the results of the clinical trial on meropenem? 

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The clinical trial on meropenem showed that continuous administration of meropenem did not improve the composite outcome of mortality and emergence of pandrug-resistant or extensively drug-resistant bacteria at day 28 in critically ill patients with sepsis . Another study found that megadose meropenem can be considered safe for empirical treatment of nosocomial sepsis . Additionally, a randomized controlled trial is planned to compare the efficacy and safety of conventional regimen and model regimen for meropenem in pediatric severe pneumonia . Another study evaluated the bactericidal activity of meropenem at different doses and found that the World Health Organization-recommended total daily dose of 6 grams daily had greater bactericidal activity compared to a lower dose of 3 grams daily . However, the tolerability of intravenous meropenem, with amoxicillin/clavulanate, was poor at all doses, raising concerns about its utility in second-line regimens .

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The results of the clinical trial on meropenem showed that the bactericidal activity was greater with a total daily dose of 6 grams compared to a lower dose of 3 grams. However, the tolerability of intravenous meropenem was poor at all doses.
The results of the clinical trial on meropenem showed that the bactericidal activity was greater with a total daily dose of 6 g compared to a lower dose of 3 g. However, the tolerability of intravenous meropenem was poor at all doses.
The results of the clinical trial on meropenem showed that megadose meropenem can be considered safe for empirical treatment of nosocomial sepsis, with no observed treatment-related adverse events.
The results of the clinical trial on meropenem showed that continuous administration did not improve the composite outcome of mortality and emergence of pandrug-resistant or extensively drug-resistant bacteria at day 28.

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