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What are the symptoms associated with a lower motor neuron injury? 

SOD1
Motor cortex
Weakness
Amyotrophic lateral sclerosis
Lesion

Answers from top 5 papers

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Papers (5)Insight
Open access•Journal Article•DOI
Amyotrophic lateral sclerosis associated with genetic abnormalities in the gene encoding Cu/Zn superoxide dismutase: molecular pathology of five new cases, and comparison with previous reports and 73 sporadic cases of ALS.
Paul G. Ince, Janine Tomkins, Janet Y. Slade, Nicola M. Thatcher, Pamela J. Shaw 
01 Oct 1998-Journal of Neuropathology and Experimental Neurology
153 Citations
This further illustrates the extent to which upper motor neuron damage in ALS is usually a distal axonopathy.
Journal Article•DOI
Fasciculations: what do we know of their significance?
Joy Desai, Michael Swash 
01 Oct 1997-Journal of the Neurological Sciences
36 Citations
Depending on the associated clinical symptoms and signs, they may signify the presence of a variety of disorders of the lower motor neuron.
Journal Article•DOI
The distribution of muscular weakness in upper motor neuron lesions affecting the arm.
James G. Colebatch, Simon C. Gandevia 
01 Jun 1989-Brain
457 Citations
These observations refine previous clinical descriptions of upper motor neuron weakness and have implications for its pathophysiology.
Journal Article•DOI
Sporadic lower motor neuron disease with Lewy body-like inclusions: a new subgroup ?*
Takeo Kato, Tadashi Katagiri, Asao Hirano, Hideo Sasaki, S. Arai 
01 Jan 1988-Acta Neuropathologica
35 Citations
The present case and two reported similar cases may constitute a new subgroup of motor neuron disease.
Journal Article•DOI
Functional MRI evidence for motor cortex reorganization adjacent to a lesion in a primary motor cortex.
Sung Ho Jang, Bong Soo Han, Yongmin Chang, Woo Mok Byun, Jun Lee, Sang Ho Ahn 
01 Nov 2002-American Journal of Physical Medicine & Rehabilitation
27 Citations
In conclusion, this finding may reflect a functional reorganization of the motor area in patients with a primary motor cortex injury.

Related Questions

What are the underlying mechanisms that lead to the recovery of lower and upper motor neurons after injury?4 answersThe recovery of lower and upper motor neurons after injury involves various mechanisms. Neuroplasticity plays a crucial role in promoting recovery by inducing adaptive changes in spared and injured neural circuitry. This includes moderate axonal sprouting, formation of new synaptic connections, network remapping, and changes to neuron cell properties. In the case of spinal cord injury (SCI), extracellular pyruvate kinase isoform M2 (PKM2) has been found to improve axonal density and motor function, mediated by valosin-containing protein (VCP) and ATPase activation. Additionally, the severity of lower motor neuron (LMN) dysfunction correlates with the extent of myelopathy and is associated with more severe paresis in both acute and chronic stages after SCI. Muscles without LMN dysfunction have a higher potential to reach full strength, while those with dysfunction display increased amplitudes of motor unit action potentials, indicating reinnervation through peripheral collateral sprouting. These findings highlight the importance of understanding and harnessing these mechanisms to enhance recovery after motor neuron injury.
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