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What behavioral factors put transgender persons at risk for HIV infection? 

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We reviewed recent epidemiological research on HIV in transgender women and show that transgender women sex workers (TSW) face unique structural, interpersonal, and individual vulnerabilities that contribute to risk for HIV.
Young transgender women are at increased risk for HIV infection due to factors related to stigma/marginalization and participation in risky sexual behaviors.
People who report having transgender sexual partners engage in higher-risk behaviours than other HIV testers yet had a lower HIV positivity.
We found this small sample of male-to-female transgender individuals to have high rates of HIV infection, and high prevalence of risky behaviors, intimate partner violence, and suicidal ideation.
Transgender women in the community may be at even greater risk for HIV infection due to behaviors compounded by substantial psychosocial stressors.
Substance use was an independent risk factor of HIV infection by increasing sexual activities and unprotected sex, which indicated an aggravated and complex situation with possible interacting syndemic factors that could cumulatively facilitate sexual risk behaviours and HIV infection in transgender women.
Thus, in our sample, transgender persons appear to be at lower risk for HIV but at higher risk for mental health concerns than men who have sex with men.
Findings on current risk behaviors among MTF transgender persons provided meaningful implications for HIV prevention interventions.

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