What can cause schizophrenia to get worse?
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(5) The few available studies on the course and outcome of schizophrenia beginning in childhood and early adolescence confirm that they are much worse than in adult-onset schizophrenia. | |
Furthermore, the effects were also small and more favourable for specific functioning measures, as opposed to more global measures, small to moderate in terms of worse outcomes for follow-up periods >10 years, small to moderate for more unfavourable outcomes in males, and small to large for worse outcomes in studies including patients diagnosed before 1970.In contrast to the adult manifestation, the early manifestation of schizophrenia in childhood and adolescence still carries a particularly poor prognosis. | |
57 Citations | This “dysplastic” model of schizophrenia can suggest testable etiology and treatment-relevant questions for the future. |
61 Citations | It is imperative that any pathogenetic model for schizophrenia takes into account what is now known about genetic mechanisms of illness. |
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What causes schizophrenia?4 answersSchizophrenia is a complex mental illness with multiple causes. The neurodevelopmental hypothesis suggests that biological factors acting in early life, such as obstetric complications, can increase the risk of developing schizophrenia. Additionally, indicators of abnormal neurodevelopment, such as motor, cognitive, and social functioning differences, have been identified in individuals who later develop schizophrenia. Metabolic disturbances, genetic factors, and environmental interactions also play a role in the development of schizophrenia. There is evidence to suggest that chronic infections of the central nervous system may contribute to some cases of schizophrenia. Furthermore, a combination of genetic susceptibility and environmental factors, such as drug misuse, ethnicity/migration, life events, and urbanicity, can increase the risk of schizophrenia. Overall, a multifactorial model that incorporates biological, social, and psychological elements is considered a more accurate representation of the causes of schizophrenia.
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