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We propose that pro-angiogenic materials should be biomimetic, incorporate angiogenic factors and mimic cooperative interactions between growth factors and the ECM.
The identification of other selective angiogenic molecules will allow insight into exciting, basic developmental issues and increase our armamentarium of factors for therapeutic angiogenic and anti-angiogenic strategies.
These findings suggest that the acceleration of tumor growth and metastasis by feeding the 3 diets may be due to the increase of angiogenic factors and the reduction of antiangiogenic factors.
Indeed, we present a number of pro- and anti-angiogenic factors, which can be also used as potential biomarkers to monitor disease progression.
Then, the angiogenic response can be directly or indirectly mediated by MMPs through the modulation of the balance between pro- and anti-angiogenic factors.
We can assume that these changes lead to matrices with increased angiogenic capabilities.
Although initial results are promising, much more work has to be done to consdier anti-angiogenic or pro-angiogenic approaches as reliable therapeutic tools.
This can partly be explained by the upregulation of alternative angiogenic pathways.
The authors identified that extracellular matrices can provide greater angiogenic potential than soluble angiogenic factors.
Also, it showed that NGF would be useful in angiogenic studies as an alternative angiogenic inducer.

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