What does apoptosis feel like?
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167 Citations | Apoptosis, unlike coagulative necrosis, does not itself evoke an inflammatory response. |
125 Citations | These phenomena indicate that apoptosis-like cell death can occur under salt stress. |
18 Citations | These ultrastructural findings represent intermediate aspects between apoptosis and necrosis and are compatible with apoptosis-like programmed cell death. |
29 Citations | These indicate an “apoptosis‐like” cell death. |
None of the HCV proteins influenced the apoptotic effect mediated via the mitochondrial apoptosis pathway while only the core protein enhanced death-receptor-mediated apoptosis. Our data showed a caspase-independent apoptosis-like effect of the core protein, which seems to be inhibited in the presence of further HCV proteins like the non structural (NS) proteins. | |
26 Citations | This finding deserves further investigation in that apoptosis may contribute to neuropathic pain conditions like CRPS. |
47 Citations | We showed that ApoptoM-induced apoptosis involves the activation of a caspase-like protease pathway. |
Open access•Journal Article 19 Citations | Toxins like alcohol probably induce apoptosis by producing active oxidants. |
70 Citations | The above are symptoms of apoptosis-like PCD. |
36 Citations | This is an apoptosis-like process, but independent of caspase activity. |
Related Questions
What is apoptosis?5 answersApoptosis is a physiological process of programmed cell death that occurs in multicellular organisms. It is responsible for tissue remodeling, normal cell turnover, and the removal of unwanted or damaged cells. Apoptosis is characterized by specific morphological, biochemical, and molecular changes, including condensation of chromatin and cytoplasm, fragmentation of the cell into apoptotic bodies, and maintenance of membrane integrity. It can be initiated by internal or external stimuli, and involves the activation of certain proteins (caspases) and the control of survival proteins (bcl-2 family). Disordered apoptosis is associated with various diseases, such as neoplasms, chronic inflammatory or autoimmune diseases, and other conditions. Imbalance in apoptosis can lead to critical situations and is a contributing factor in neurodegenerative diseases, ischemic damage, autoimmune disorders, and cancer. Apoptosis occurs in many physiological and pathological processes, and plays a role in tissue involution, embryonic development, and tumor malignancy.
How do people want to die?5 answersStep 1: Answer without citation
People's preferences for how they want to die vary widely. Some individuals express a desire for a sudden, unexpected death, while others prefer a gradual decline that allows them time to fulfill their last wishes and put their affairs in order. Factors such as the fear of suffering, the desire for a meaningful life, and the awareness of a terminal prognosis play significant roles in shaping these preferences.
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Step 3: Answer with citation
Some individuals express a desire for a sudden, unexpected death, while others prefer a gradual decline that allows them time to fulfill their last wishes and put their affairs in order. Factors such as the fear of suffering, the desire for a meaningful life, and the awareness of a terminal prognosis play significant roles in shaping these preferences.
What are some features of apoptosis?5 answersApoptosis, or programmed cell death, is a highly regulated process with several characteristic features. These features include membrane blebbing, nuclear condensation, DNA fragmentation, and cell shrinkage. Apoptotic cells also form apoptotic bodies, which are phagocytized by neighboring cells without releasing cellular contents. These morphological changes distinguish apoptosis from necrosis, where cellular contents are released. Apoptosis plays important roles in maintaining cell homeostasis, eliminating unwanted or damaged cells, and regulating cell survival and death. Defects in apoptosis can lead to diseases such as cancer and autoimmune diseases. Understanding the molecular mechanisms of apoptosis, including the involvement of caspases, gene families, and signaling pathways, provides insights for developing strategies to regulate cell survival and death.
How does apoptosis affect brain injury?5 answersApoptosis, or programmed cell death, plays a significant role in brain injury. It has been observed that apoptosis contributes to the overall pathology of traumatic brain injury (TBI) in both humans and animals. Apoptotic cell death has been identified in contusional brain lesions during the acute phase of TBI, as well as in regions remote from the directly injured site in the days and weeks following trauma. Neuronal apoptosis has been found to occur in the brain following hypoxia-ischemia, a common perinatal complication, and is associated with subsequent neurological deficits. The inhibition of apoptosis has the potential to reverse the deleterious effects of head injury and improve functional outcomes. Understanding the apoptotic pathway and its role in brain injury can provide targets for therapeutic intervention.
What is Apoptosis?5 answersApoptosis is a programmed and controlled form of cell death that plays a role in the regulation of animal cell populations and is involved in cell turnover in healthy adult tissues. It is characterized by morphological and biochemical changes in the cell, including nuclear and cytoplasmic condensation and fragmentation. These apoptotic bodies are either shed from surfaces or taken up by other cells and degraded by lysosomal enzymes. Apoptosis is implicated in various physiological processes such as morphogenesis, homeostasis, and differentiation, and is also responsible for tissue loss and cell eradication in diseases like neoplasias and cancers. It is a constitutive suicide program expressed in most cells and can be triggered by various signals. Dysregulation of apoptosis can contribute to human diseases, and understanding its signaling pathways may lead to therapeutic interventions.
What does it feel like to have tuberculosis Reddit?5 answers