What drug is effective in treating biofilm infections due to chelating of Fe and Zn ions in biofilm matrix?
Answers from top 1 papers
More filters
| Papers (1) | Insight |
|---|---|
| From this study, we conclude that the molecules considered here might be used to treat biofilm-associated infections after significant structural modifications, thereby investigating its effective delivery in the host. |
Related Questions
How does iron influence biofilm formation in paddy system?5 answersIron plays a significant role in biofilm formation in paddy systems. Iron plaque on rice roots acts as a sink and source of iron, impacting iron cycling in paddy fields. The formation of iron plaque is driven by radial oxygen loss (ROL), which leads to rhizosphere iron oxidation. The presence of iron-reducing bacteria (IRB) in paddy soils also influences biofilm formation. The redox cycling of iron by IRB affects the release and immobilization of arsenic in paddy soils. Additionally, the tolerance of paddy weeds and rice varieties to iron affects their germination and root elongation, which can impact biofilm formation. Therefore, iron availability and the activity of IRB are crucial factors in biofilm formation in paddy systems.
How does iron plaque help in biofilm formation in soil?5 answersIron plaque on the root surface in wetland plants plays a role in biofilm formation in soil. The formation of iron plaque is influenced by various factors such as Fe2+ concentration, the oxidizing capability of the root system, and plant species. Iron plaque is a mixture of iron oxide or hydroxide, mainly composed of ferric hydroxides, goethite, and lepidocrocite. It acts as a physical "barrier" to the uptake of heavy metals through immobilization and co-precipitation, thereby influencing the chemical behavior and bioavailability of heavy metals and nutrient elements in the rhizosphere. The amount of iron plaque on the root surface is related to its nutritional effect on plants, as it serves as an enriched reservoir of plant nutrient elements. However, the relationship between iron plaque formation and the uptake of heavy metals is still not fully understood, with inconsistent results reported in different studies. Further research is needed to understand the control of iron plaque formation and its mechanism of action on heavy metals uptake.
What are possible compounds or treatments that could inhibit or disrupt biofilm formation without harming the host's tissues?5 answersPossible compounds or treatments that could inhibit or disrupt biofilm formation without harming the host's tissues include natural compounds such as alkyl gallates, gallic acid and its esters, which can prevent biofilm development and eradicate mature biofilms by suppressing the synthesis of the extracellular polymeric matrix, inhibiting quorum-sensing signaling, and altering the microbial cell membrane. Other natural compounds like curcumin, cinnamaldehyde, eugenol, carvacrol, thymol, terpinen-4-ol, linalool, geraniol, cineole, saponin, camphor, borneol, camphene, carnosol, citronellol, coumarin, epigallocatechin gallate, eucalyptol, limonene, menthol, piperine, α-terpineol, β–pinene, and citral have also been used to inhibit and destroy Candida biofilms. Additionally, nutraceutical enzyme and botanical blends containing enzymes targeted at lipids, proteins, and sugars, along with antimicrobial extracts from cranberry, berberine, rosemary, and peppermint, have shown promise in disrupting biofilm communities. Furthermore, compounds like actinomycin X2, actinomycin D, rifaximin, and imatinib have been shown to inhibit the activity of the deacetylase Agd3, which is essential for biofilm formation in Aspergillus fumigatus. These compounds and treatments offer potential strategies for combating biofilm-associated infections while minimizing harm to the host's tissues.
What are possible compounds or treatments that could inhibit or disrupt biofilm formation without harming the host's tissues?2 answersPossible compounds and treatments that could inhibit or disrupt biofilm formation without harming the host's tissues include: isolation of quorum-sensing inhibitors, metal chelators, and biofilm efflux pump inhibitors from medicinal plants; carbonic anhydrase inhibitors, urease inhibitors, Ca2+ ATPase inhibitors, tlp activators, and myo-inositol catabolism pathway activators; phytochemicals and herbal drugs that have shown promising results in inhibiting biofilm formation; and methods that inhibit biofilm formation where the extracellular matrix in the biofilm includes poly-β-(1→6)glucosamine structures. Additionally, ultrasound-induced inertial cavitation has been proposed as a novel strategy to increase antibiotic efficacy by mechanically disrupting the biofilm and increasing vulnerability to antibiotics.
What are the most promising therapeutic strategies for combating biofilm mediated infections?3 answersThe most promising therapeutic strategies for combating biofilm mediated infections include targeting the extracellular polymeric substance (EPS) of biofilms, using dispersal molecules to break up biofilm structures, targeting quorum sensing to disrupt communication within biofilms, targeting dormant cells within biofilms, and developing antimicrobial dental materials and photodynamic therapy for oral biofilm infections. Other strategies being explored include using peptides, amino acids, fatty acids, lipids, enzymes, small molecules, metabolites, nanoparticles, and living cells to prevent biofilm formation and treat existing biofilm infections. Additionally, the development of biofilm eradication agents is a fundamental area of research, with the aim of directly treating and eradicating established biofilms. These therapeutic strategies offer promising prospects for the future of biofilm therapeutics and have the potential to address infections that are currently resistant to conventional antibiotics.
What medications have zinc in it?3 answers